Search Results - "Paroo, Zain"

Phosphorylation of the Human MicroRNA-Generating Complex Mediates MAPK/Erk Signaling by Paroo, Zain, Ye, Xuecheng, Chen, She, Liu, Qinghua

“…MicroRNAs (miRNAs) govern an expanding number of biological and disease processes. Understanding the mechanisms by which the miRNA pathway is regulated,…”
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Structure of C3PO and mechanism of human RISC activation by Liu, Qinghua, Zhang, Hong, Ye, Xuecheng, Huang, Nian, Liu, Ying, Paroo, Zain, Huerta, Carlos, Li, Peng, Chen, She

“…Generating a complex competent for RNA interference requires cutting and removal of the non-guide siRNA strand. Reconstitution of human RISC activity now shows…”
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Functional Anatomy of the Drosophila MicroRNA-generating Enzyme by Ye, Xuecheng, Paroo, Zain, Liu, Qinghua

“…In Drosophila melanogaster, the multidomain RNase III Dicer-1 (Dcr-1) functions in tandem with the double-stranded (ds)RNA-binding protein Loquacious (Loqs) to…”
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Iron Homeostasis Regulates the Activity of the MicroRNA Pathway through Poly(C)-Binding Protein 2 by Li, Yujing, Lin, Li, Li, Zigang, Ye, Xuecheng, Xiong, Ke, Aryal, Baikuntha, Xu, Zihui, Paroo, Zain, Liu, Qinghua, He, Chuan, Jin, Peng

“…MicroRNAs (miRNAs) control gene expression by promoting degradation or repressing translation of target mRNAs. The components of the miRNA pathway are subject…”
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Dicer's Cut and Switch by Liu, Qinghua, Paroo, Zain

“…An enzyme that cleaves RNA is converted to a DNA-cleaving enzyme during programmed cell death in Caenorhabditis elegans . Apoptosis is an essential…”
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Rescuing dicer Defects via Inhibition of an Anti-Dicing Nuclease by Asada, Ken, Canestrari, Emanuele, Fu, Xiuping, Li, Zhi, Makowski, Edward, Wu, Yen-Ching, Mito, Jeffrey K., Kirsch, David G., Baraban, Jay, Paroo, Zain

“…Genetic defects in the microRNA (miRNA) generating enzyme, dicer, are increasingly linked to disease. Loss of miRNA in dicer deficiency is thought to be due to…”
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Biodistribution of phosphodiester and phosphorothioate siRNA by BRAASCH, Dwaine A, PAROO, Zain, CONSTANTINESCU, Anca, GANG REN, ÖZ, Orhan K, MASON, Ralph P, COREY, David R

“…Short interfering RNAs (siRNAs) are valuable tools for analyzing protein function in mammalian cell culture. This success has led to high expectations for in…”
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A small molecule enhances RNA interference and promotes microRNA processing by Jin, Peng, Shan, Ge, Li, Yujing, Zhang, Junliang, Li, Wendi, Szulwach, Keith E, Duan, Ranhui, Faghihi, Mohammad A, Khalil, Ahmad M, Lu, Lianghua, Paroo, Zain, Chan, Anthony W S, Shi, Zhangjie, Liu, Qinghua, Wahlestedt, Claes, He, Chuan

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Exercise Improves Postischemic Cardiac Function in Males but Not Females: Consequences of a Novel Sex-Specific Heat Shock Protein 70 Response by Paroo, Zain, Haist, James V, Karmazyn, Morris, Noble, Earl G

“…Exercise is a physiological inducer of the cardioprotective heat shock protein, Hsp70. The putative biological events involved in signaling this response…”
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Biochemical principles of small RNA pathways by Liu, Qinghua, Paroo, Zain

“…The discovery of RNA interference (RNAi) is among the most significant biomedical breakthroughs in recent history. Multiple classes of small RNA, including…”
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Ribonucleases as Drug Targets by Canestrari, Emanuele, Paroo, Zain

“…Across disease indications, there is immediate need for new drug targets. Target scarcity is reflected in a growing number of same-target drugs of marginal…”
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Estrogen attenuates postexercise HSP70 expression in skeletal muscle by Paroo, Zain, Dipchand, Elizabeth S, Noble, Earl G

“…Exercise has been demonstrated as a physiological inducer of heat shock protein (HSP)70. Many of the proposed signals of this response exhibit sexual…”
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ATP-dependent human RISC assembly pathways by Tomari, Yukihide, Yoda, Mayuko, Kawamata, Tomoko, Paroo, Zain, Ye, Xuecheng, Iwasaki, Shintaro, Liu, Qinghua

“…Small RNAs function within the context of RNA-induced silencing complexes (RISCs) containing Argonaute (AGO) subfamily proteins. Experiments now show that…”
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A druggable target for rescuing microRNA defects by Asada, Ken, Canestrari, Emanuele, Paroo, Zain

“…[Display omitted] Despite immense promise, development of microRNA (miRNA) therapeutics remains limited by pharmacodynamic challenges that have hindered…”
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Molecular biology. Dicer's cut and switch by Liu, Qinghua, Paroo, Zain

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A small molecule enhances RNA interference and promotes microRNA processing by Shan, Ge, Li, Yujing, Zhang, Junliang, Li, Wendi, Szulwach, Keith E, Duan, Ranhui, Faghihi, Mohammad A, Khalil, Ahmad M, Lu, Lianghua, Paroo, Zain, Chan, Anthony W S, Shi, Zhangjie, Liu, Qinghua, Wahlestedt, Claes, He, Chuan, Jin, Peng

“…Little is known about the regulation of RNA interference (RNAi). Shan et al . constructed a reporter system to monitor RNAi activity and identified a small…”
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Validating Bioluminescence Imaging as a High-Throughput, Quantitative Modality for Assessing Tumor Burden by Paroo, Zain, Bollinger, Robert A., Braasch, Dwaine A., Richer, Edmond, Corey, David R., Antich, Peter P., Mason, Ralph P.

“…Bioluminescence imaging (BLI) is a highly sensitive tool for visualizing tumors, neoplastic development, metastatic spread, and response to therapy. Although…”
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Challenges for RNAi in vivo by Paroo, Zain, Corey, David R.

“…Synthetic small interfering RNA (siRNA) has become a valuable tool for investigating gene function in cell culture. This success has led to high expectations…”
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Biochemical mechanisms of the RNA-induced silencing complex by Paroo, Zain, Liu, Qinghua, Wang, Xiaodong

“…In less than 10 years since its inception, RNA interference (RNAi) has had extraordinary impact on biomedical science. RNAi has been demonstrated to influence…”
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Phosphorylation of the human micro-RNA generating complex mediates MAPK/Erk signaling by Paroo, Zain, Ye, Xuecheng, Chen, She, Liu, Qinghua

“…MicroRNA (miRNA) govern an expanding number of biological and disease processes. Understanding the mechanisms by which the miRNA pathway is regulated,…”
Get full text