Search Results - "Parolia, Abhijit"

Distinct structural classes of activating FOXA1 alterations in advanced prostate cancer by Parolia, Abhijit, Cieslik, Marcin, Chu, Shih-Chun, Xiao, Lanbo, Ouchi, Takahiro, Zhang, Yuping, Wang, Xiaoju, Vats, Pankaj, Cao, Xuhong, Pitchiaya, Sethuramasundaram, Su, Fengyun, Wang, Rui, Feng, Felix Y., Wu, Yi-Mi, Lonigro, Robert J., Robinson, Dan R., Chinnaiyan, Arul M.

“…Abtract Forkhead box A1 (FOXA1) is a pioneer transcription factor that is essential for the normal development of several endoderm-derived organs, including…”
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Targeting SWI/SNF ATPases in enhancer-addicted prostate cancer by Xiao, Lanbo, Parolia, Abhijit, Qiao, Yuanyuan, Bawa, Pushpinder, Eyunni, Sanjana, Mannan, Rahul, Carson, Sandra E., Chang, Yu, Wang, Xiaoju, Zhang, Yuping, Vo, Josh N., Kregel, Steven, Simko, Stephanie A., Delekta, Andrew D., Jaber, Mustapha, Zheng, Heng, Apel, Ingrid J., McMurry, Lisa, Su, Fengyun, Wang, Rui, Zelenka-Wang, Sylvia, Sasmal, Sanjita, Khare, Leena, Mukherjee, Subhendu, Abbineni, Chandrasekhar, Aithal, Kiran, Bhakta, Mital S., Ghurye, Jay, Cao, Xuhong, Navone, Nora M., Nesvizhskii, Alexey I., Mehra, Rohit, Vaishampayan, Ulka, Blanchette, Marco, Wang, Yuzhuo, Samajdar, Susanta, Ramachandra, Murali, Chinnaiyan, Arul M.

“…The switch/sucrose non-fermentable (SWI/SNF) complex has a crucial role in chromatin remodelling 1 and is altered in over 20% of cancers 2 , 3 . Here we…”
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The non-coding transcriptome as a dynamic regulator of cancer metastasis by Crea, Francesco, Clermont, Pier Luc, Parolia, Abhijit, Wang, Yuzhuo, Helgason, Cheryl D.

“…Since the discovery of microRNAs, non-coding RNAs (NC-RNAs) have increasingly attracted the attention of cancer investigators. Two classes of NC-RNAs are…”
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Lowered H3K27me3 and DNA hypomethylation define poorly prognostic pediatric posterior fossa ependymomas by Bayliss, Jill, Mukherjee, Piali, Lu, Chao, Jain, Siddhant U, Chung, Chan, Martinez, Daniel, Sabari, Benjamin, Margol, Ashley S, Panwalkar, Pooja, Parolia, Abhijit, Pekmezci, Melike, McEachin, Richard C, Cieslik, Marcin, Tamrazi, Benita, Garcia, Benjamin A, La Rocca, Gaspare, Santi, Mariarita, Lewis, Peter W, Hawkins, Cynthia, Melnick, Ari, David Allis, C, Thompson, Craig B, Chinnaiyan, Arul M, Judkins, Alexander R, Venneti, Sriram

“…Childhood posterior fossa (PF) ependymomas cause substantial morbidity and mortality. These tumors lack recurrent genetic mutations, but a subset of these…”
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Distinct mutational processes shape selection of MHC class I and class II mutations across primary and metastatic tumors by Mumphrey, Michael B., Hosseini, Noshad, Parolia, Abhijit, Geng, Jie, Zou, Weiping, Raghavan, Malini, Chinnaiyan, Arul, Cieslik, Marcin

“…Disruption of antigen presentation via loss of major histocompatibility complex (MHC) expression is a strategy whereby cancer cells escape immune surveillance…”
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Identification of a long non-coding RNA as a novel biomarker and potential therapeutic target for metastatic prostate cancer by Crea, Francesco, Watahiki, Akira, Quagliata, Luca, Xue, Hui, Pikor, Larissa, Parolia, Abhijit, Wang, Yuwei, Lin, Dong, Lam, Wan L, Farrar, William L, Isogai, Takao, Morant, Rudolf, Castori-Eppenberger, Serenella, Chi, Kim N, Wang, Yuzhuo, Helgason, Cheryl D

“…Metastatic prostate cancer (PCa) is still an incurable disease. Long non-coding RNAs (lncRNAs) may be an overlooked source of cancer biomarkers and therapeutic…”
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miR-100-5p inhibition induces apoptosis in dormant prostate cancer cells and prevents the emergence of castration-resistant prostate cancer by Nabavi, Noushin, Saidy, Nur Ridzwan Nur, Venalainen, Erik, Haegert, Anne, Parolia, Abhijit, Xue, Hui, Wang, Yuwei, Wu, Rebecca, Dong, Xin, Collins, Colin, Crea, Francesco, Wang, Yuzhuo

“…Carcinoma of the prostate is the most common cancer in men. Treatment of aggressive prostate cancer involves a regiment of radical prostectomy, radiation…”
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PIKfyve, expressed by CD11c-positive cells, controls tumor immunity by Choi, Jae Eun, Qiao, Yuanyuan, Kryczek, Ilona, Yu, Jiali, Gurkan, Jonathan, Bao, Yi, Gondal, Mahnoor, Tien, Jean Ching-Yi, Maj, Tomasz, Yazdani, Sahr, Parolia, Abhijit, Xia, Houjun, Zhou, JiaJia, Wei, Shuang, Grove, Sara, Vatan, Linda, Lin, Heng, Li, Gaopeng, Zheng, Yang, Zhang, Yuping, Cao, Xuhong, Su, Fengyun, Wang, Rui, He, Tongchen, Cieslik, Marcin, Green, Michael D., Zou, Weiping, Chinnaiyan, Arul M.

“…Cancer treatment continues to shift from utilizing traditional therapies to targeted ones, such as protein kinase inhibitors and immunotherapy. Mobilizing…”
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The long non-coding RNA PCGEM1 is regulated by androgen receptor activity in vivo by Parolia, Abhijit, Crea, Francesco, Xue, Hui, Wang, Yuwei, Mo, Fan, Ramnarine, Varune Rohan, Liu, Hui Hsuan, Lin, Dong, Saidy, Nur Ridzwan Nur, Clermont, Pier-Luc, Cheng, Hongwei, Collins, Colin, Wang, Yuzhuo, Helgason, Cheryl D

“…Long non-coding RNAs (lncRNAs) can orchestrate oncogenic or tumor-suppressive functions in cancer biology. Accordingly, PCGEM1 and PRNCR1 were implicated in…”
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The long noncoding RNA HORAS5 mediates castration‐resistant prostate cancer survival by activating the androgen receptor transcriptional program by Parolia, Abhijit, Venalainen, Erik, Xue, Hui, Mather, Rebecca, Lin, Dong, Wu, Rebecca, Pucci, Perla, Rogalski, Jason, Evans, Joseph R., Feng, Felix, Collins, Colin C., Wang, Yuzhuo, Crea, Francesco

“…Prostate cancer (PCa) is driven by the androgen receptor (AR)‐signaling axis. Hormonal therapy often mitigates PCa progression, but a notable number of cases…”
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The evolutionarily conserved long non‐coding RNA LINC00261 drives neuroendocrine prostate cancer proliferation and metastasis via distinct nuclear and cytoplasmic mechanisms by Mather, Rebecca L., Parolia, Abhijit, Carson, Sandra E., Venalainen, Erik, Roig‐Carles, David, Jaber, Mustapha, Chu, Shih‐Chun, Alborelli, Ilaria, Wu, Rebecca, Lin, Dong, Nabavi, Noushin, Jachetti, Elena, Colombo, Mario P., Xue, Hui, Pucci, Perla, Ci, Xinpei, Hawkes, Cheryl, Li, Yinglei, Pandha, Hardev, Ulitsky, Igor, Marconett, Crystal, Quagliata, Luca, Jiang, Wei, Romero, Ignacio, Wang, Yuzhuo, Crea, Francesco

“…Metastatic neuroendocrine prostate cancer (NEPC) is a highly aggressive disease, whose incidence is rising. Long noncoding RNAs (lncRNAs) represent a large…”
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Integrated analysis of the prostate cancer small-nucleolar transcriptome reveals SNORA55 as a driver of prostate cancer progression by Crea, Francesco, Quagliata, Luca, Michael, Agnieszka, Liu, Hui Hsuan, Frumento, Paolo, Azad, Arun A., Xue, Hui, Pikor, Larissa, Watahiki, Akira, Morant, Rudolf, Eppenberger-Castori, Serenella, Wang, Yuwei, Parolia, Abhijit, Lennox, Kim A., Lam, Wan L., Gleave, Martin, Chi, Kim N., Pandha, Hardev, Wang, Yuzhuo, Helgason, Cheryl D.

“…Metastasis is the primary cause of death in prostate cancer (PCa) patients. Small nucleolar RNAs (snoRNAs) have long been considered “housekeeping” genes with…”
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Identification of the epigenetic reader CBX2 as a potential drug target in advanced prostate cancer by Clermont, Pier-Luc, Crea, Francesco, Chiang, Yan Ting, Lin, Dong, Zhang, Amy, Wang, James Z L, Parolia, Abhijit, Wu, Rebecca, Xue, Hui, Wang, Yuwei, Ding, Jiarui, Thu, Kelsie L, Lam, Wan L, Shah, Sohrab P, Collins, Colin C, Wang, Yuzhuo, Helgason, Cheryl D

“…While localized prostate cancer (PCa) can be effectively cured, metastatic disease inevitably progresses to a lethal state called castration-resistant prostate…”
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GENT-32. COMPREHENSIVE TRANSCRIPTOMIC ANALYSIS OF PEDIATRIC AND ADULT HUMAN BRAIN TUMORS FOR DISCOVERY OF BRAIN TUMOR-ASSOCIATED LONG NON-CODING RNAS by Niknafs, Yashar, Parolia, Abhijit

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Non-invasive metabolic imaging of brain tumours in the era of precision medicine by Kim, Michelle M., Parolia, Abhijit, Dunphy, Mark P., Venneti, Sriram

“…Key Points Brain tumours, such as gliomas, in adults and children are morphologically similar, but harbour different genomic alterations, both across and…”
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Abstract 4420: Polytect, a robust algorithm to detect somatic mutations in polymorphic MHC/HLA genes by Mumphrey, Michael Brodie, Parolia, Abhijit, Kumar-Sinha, Chandan, Cieslik, Marcin

“…Abstract Background: The immune system is able to recognize tumor cells through the presentation of mutant peptides via the major histocompatibility complex…”
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Targeting transcriptional regulation of SARS-CoV-2 entry factors ACE2 and TMPRSS2 by Qiao, Yuanyuan, Wang, Xiao-Ming, Mannan, Rahul, Pitchiaya, Sethuramasundaram, Zhang, Yuping, Wotring, Jesse W., Xiao, Lanbo, Robinson, Dan R., Wu, Yi-Mi, Tien, Jean Ching-Yi, Cao, Xuhong, Simko, Stephanie A., Apel, Ingrid J., Bawa, Pushpinder, Kregel, Steven, Narayanan, Sathiya P., Raskind, Gregory, Ellison, Stephanie J., Parolia, Abhijit, Zelenka-Wang, Sylvia, McMurry, Lisa, Su, Fengyun, Wang, Rui, Cheng, Yunhui, Delekta, Andrew D., Mei, Zejie, Pretto, Carla D., Wang, Shaomeng, Mehra, Rohit, Sexton, Jonathan Z., Chinnaiyan, Arul M.

“…Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus responsible for COVID-19, employs two key host proteins to gain entry and replicate…”
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Abstract 3347: Exploring the role of ASXL family of genes in enabling oncogenic AR-signaling in prostate cancer by Parolia, Abhijit, Cao, Xuhong, Chinnaiyan, Arul

“…Abstract Prostate cancer (PCa) is the second leading cause of cancer-related mortality in North American men. In recent years, there has been mounting evidence…”
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Competing for enhancers: PVT1 fine-tunes MYC expression by Parolia, Abhijit, Cieślik, Marcin, Chinnaiyan, Arul M.

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Discovery of LLC0424 as a Potent and Selective in Vivo NSD2 PROTAC Degrader by Liu, Lianchao, Parolia, Abhijit, Liu, Yihan, Hou, Caiyun, He, Tongchen, Qiao, Yuanyuan, Eyunni, Sanjana, Luo, Jie, Li, Chungen, Wang, Yongxing, Zhou, Fengtao, Huang, Weixue, Ren, Xiaomei, Wang, Zhen, Chinnaiyan, Arul M., Ding, Ke

“…Nuclear receptor-binding SET domain-containing 2 (NSD2), a methyltransferase that primarily installs the dimethyl mark on lysine 36 of histone 3 (H3K36me2),…”
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