Comparison of caffeine-induced locomotor activity between adolescent and adult rats

Comparison of caffeine-induced locomotor activity between adolescent and adult rats

Caffeine is the psychostimulant drug most consumed in the world. This drug is present in food, beverages and medicines marketed for individuals of all ages. In spite of this, caffeine effects on adolescents are poorly understood. The aim of this study was to evaluate the differences on caffeine-indu...

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Bibliographic Details
Published in:European journal of pharmacology Vol. 660; no. 2-3; pp. 363 - 367
Main Authors: Marin, Marcelo T., Zancheta, Roberta, Paro, Ana H., Possi, Ana P.M., Cruz, Fábio C., Planeta, Cleopatra S.
Format: Journal Article
Language:English
Published: Amsterdam Elsevier B.V 25-06-2011
Elsevier
Subjects:
Adolescence
Aging - physiology
Animals
Biological and medical sciences
Caffeine
Caffeine - pharmacology
Dose-Response Relationship, Drug
Habituation, Psychophysiologic - drug effects
Habituation, Psychophysiologic - physiology
Locomotor activity
Male
Medical sciences
Motor Activity - drug effects
Motor Activity - physiology
Pharmacology. Drug treatments
Psychostimulant
Rats
Rats, Wistar
Adolescence
Psychostimulant
Locomotor activity
Caffeine
Rat
CNS stimulant
Psychotropic
Rodentia
Young animal
Respiratory analeptic
Locomotion
Vertebrata
Mammalia
Adult animal
Xanthine derivatives
Comparative study
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Summary:Caffeine is the psychostimulant drug most consumed in the world. This drug is present in food, beverages and medicines marketed for individuals of all ages. In spite of this, caffeine effects on adolescents are poorly understood. The aim of this study was to evaluate the differences on caffeine-induced locomotor stimulant or depressant effects in adolescent and adult rats. Adolescent (37–40days old) or adult (70–74days old) Wistar rats were tested for stimulant and depressant caffeine effects in two different experiments. The first was designed to evaluate the locomotor effect of caffeine in habituated rats. To this end, rats were previously habituated to test environment and had their locomotor activity registered following i.p. injections of vehicle or caffeine (3, 10, 30, 60 or 120mg/kg). In the second experiment adolescent or adult rats were not habituated to the test environment and their locomotor activity was registered following i.p. injections of vehicle or caffeine (30, 60 or 120mg/kg). In both experiments caffeine-induced a biphasic effect, with stimulation in small to moderate drug doses and no effect or locomotor depression in higher caffeine doses. Moreover, caffeine-induced locomotor stimulation was higher in adolescent than adult rats. Also, locomotor depression was only revealed in adult rats non-habituated to the test environment. These results suggest that adult and adolescent respond differently to caffeine indicating the need of more studies on the effects of caffeine in animals' models of adolescence.
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ISSN:0014-2999
1879-0712
DOI:10.1016/j.ejphar.2011.03.052