Search Results - "Parnas, B L"

Discovery of Chiral N,N-Disubstituted Trifluoro-3-amino-2-propanols as Potent Inhibitors of Cholesteryl Ester Transfer Protein by Durley, Richard C, Grapperhaus, Margaret L, Massa, Mark A, Mischke, Deborah A, Parnas, Barry L, Fobian, Yvette M, Rath, Nigam P, Honda, Dorothy D, Zeng, Ming, Connolly, Daniel T, Heuvelman, Deborah M, Witherbee, Bryan J, Glenn, Kevin C, Krul, Elaine S, Smith, Mark E, Sikorski, James A

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Structural determinants of haloenol lactone-mediated suicide inhibition of canine myocardial calcium-independent phospholipase A2 by Zupan, Lori A., Weiss, Randy H., Hazen, Stanley L., Parnas, Barry L., Aston, Karl W., Lennon, Patrick J., Getman, Daniel P., Gross, Richard W.

“…Haloenol lactones are potent mechanism-based inhibitors of a novel class of calcium-independent phospholipases A2 which have been implicated as the enzymic…”
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Structure-activity relationship studies on 1-[2-(4-Phenylphenoxy)ethyl]pyrrolidine (SC-22716), a potent inhibitor of leukotriene A(4) (LTA(4)) hydrolase by Penning, T D, Chandrakumar, N S, Chen, B B, Chen, H Y, Desai, B N, Djuric, S W, Docter, S H, Gasiecki, A F, Haack, R A, Miyashiro, J M, Russell, M A, Yu, S S, Corley, D G, Durley, R C, Kilpatrick, B F, Parnas, B L, Askonas, L J, Gierse, J K, Harding, E I, Highkin, M K, Kachur, J F, Kim, S H, Krivi, G G, Villani-Price, D, Pyla, E Y, Smith, W G

“…Leukotriene B(4) (LTB(4)) is a pro-inflammatory mediator that has been implicated in the pathogenesis of a number of diseases including inflammatory bowel…”
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Isolation and Structure of Leukotriene-A4 Hydrolase Inhibitor:  8(S)-Amino-2(R)-methyl-7-oxononanoic Acid Produced by Streptomyces diastaticus by Parnas, Barry L, Durley, Richard C, Rhoden, Eric E, Kilpatrick, Brian F, Makkar, Narinder, Thomas, Kristin E, Smith, Walter G, Corley, David G

“…The novel amino acid 8(S)-amino-2(R)-methyl-7-oxononanoic acid (1) was isolated from the soil-borne microorganism Streptomyces diastaticus during our screening…”
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Chiral N,N-Disubstituted Trifluoro-3-Amino-2-Propanols Are Potent Inhibitors of Cholesteryl Ester Transfer Protein by Durley, Richard C, Grapperhaus, Margaret L, Hickory, Brian S, Massa, Mark A, Wang, Jane L, Spangler, Dale P, Mischke, Deborah A, Parnas, Barry L, Fobian, Yvette M, Rath, Nigam P, Honda, Dorothy D, Zeng, Ming, Connolly, Daniel T, Heuvelman, Deborah M, Witherbee, Bryan J, Melton, Michele A, Glenn, Kevin C, Krul, Elaine S, Smith, Mark E, Sikorski, James A

“…A novel series of substituted N-benzyl-N-phenyl-trifluoro-3-amino-2-propanols are described that reversibly inhibit cholesteryl ester transfer protein (CETP)…”
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Isolation and structure of leukotriene-A sub(4) hydrolase inhibitor: 8(S)-amino-2(R)-methyl-7-oxononanoic acid produced by Streptomyces diastaticus by Parnas, B L, Durley, R C, Rhoden, EE, Kilpatrick, B F, Makkar, N, Thomas, KE, Smith, W G, Corley, D G

“…The novel amino acid 8(S)-amino-2(R)-methyl-7-oxononanoic acid (1) was isolated from the soil-borne microorganism Streptomyces diastaticus during our screening…”
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