Cephalosporins Associated Pseudomembraneous Colitis in an Elderly Male Patient - A Case Report

Incidence of antibiotic- associated diarrhoea is a common (10-30%) but pseudomembranous colitis (PMC) is less frequent (1-5%). Fluoroquinolones, clindamycin, penicillins, cephalosporins (mostly third generation) are commonly associated with PMC. The association between cephalosporins and PMC is now...

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Bibliographic Details
Published in:	Current drug safety Vol. 12; no. 3; p. 205
Main Authors:	Parmar, Prashant M, Solanki, Vipul V, Barvaliya, Manish J, Chavada, Bhavesh C, Tripathi, Chandrabhanu Rajkishor
Format:	Journal Article
Language:	English
Published:	United Arab Emirates 01-01-2017
Subjects:	Aged Anti-Bacterial Agents - administration & dosage Anti-Bacterial Agents - adverse effects Cefazolin - administration & dosage Cefazolin - adverse effects Ceftriaxone - administration & dosage Ceftriaxone - adverse effects Cephalosporins - administration & dosage Cephalosporins - adverse effects Drug Therapy, Combination Enterocolitis, Pseudomembranous - chemically induced Enterocolitis, Pseudomembranous - diagnostic imaging Fatal Outcome Humans Male Pseudomembraneous colitis ceftriaxone MSCT cephalosporins clostidium difficile cefazoline
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Summary:	Incidence of antibiotic- associated diarrhoea is a common (10-30%) but pseudomembranous colitis (PMC) is less frequent (1-5%). Fluoroquinolones, clindamycin, penicillins, cephalosporins (mostly third generation) are commonly associated with PMC. The association between cephalosporins and PMC is now well established. A 78 year old male patient developed pseudomembraneous colitis after administration of Ceftriaxone and Cefazoline for the treatment of pleural effusion. The reaction was confirmed by ultrasonography and CT scan. Causative agents were stopped and patient was managed by systemic therapy. Patient was expired due to respiratory complications as there was complexity in management of disease due to development of pseudomembraneous colitis. Increase awareness of prescribers for high-risk drugs, close monitoring, with immediate withdrawal of the culprit drug can reduce the complexity of management that occur due to development of such adverse drug reaction.
ISSN:	2212-3911
DOI:	10.2174/1574886312666170616091217