Search Results - "Parlakgul, Günes"

Brown adipose tissue thermogenic adaptation requires Nrf1-mediated proteasomal activity by Bartelt, Alexander, Widenmaier, Scott B, Schlein, Christian, Johann, Kornelia, Goncalves, Renata L S, Eguchi, Kosei, Fischer, Alexander W, Parlakgül, Günes, Snyder, Nicole A, Nguyen, Truc B, Bruns, Oliver T, Franke, Daniel, Bawendi, Moungi G, Lynes, Matthew D, Leiria, Luiz O, Tseng, Yu-Hua, Inouye, Karen E, Arruda, Ana Paula, Hotamisligil, Gökhan S

“…Nrf1-mediated proteosome activity in brown fat is required for the normal thermogenic behavior of this tissue in mice. Adipocytes possess remarkable adaptive…”
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Defective STIM-mediated store operated Ca2+ entry in hepatocytes leads to metabolic dysfunction in obesity by Arruda, Ana Paula, Pers, Benedicte Mengel, Parlakgul, Günes, Güney, Ekin, Goh, Ted, Cagampan, Erika, Lee, Grace Yankun, Goncalves, Renata L, Hotamisligil, Gökhan S

“…Defective Ca 2+ handling is a key mechanism underlying hepatic endoplasmic reticulum (ER) dysfunction in obesity. ER Ca 2+ level is in part monitored by the…”
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Integration of ER protein quality control mechanisms defines β cell function and ER architecture by Shrestha, Neha, Torres, Mauricio, Zhang, Jason, Lu, You, Haataja, Leena, Reinert, Rachel B, Knupp, Jeffrey, Chen, Yu-Jie, Parlakgul, Gunes, Arruda, Ana Paula, Tsai, Billy, Arvan, Peter, Qi, Ling

“…Three principal ER quality-control mechanisms, namely, the unfolded protein response, ER-associated degradation (ERAD), and ER-phagy are each important for the…”
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Type I Interferons Interfere with Liver Glucose Metabolism by Parlakgul, Güneş, Hotamisligil, Gökhan S.

“…The specific immunological components linking metabolic stresses to liver inflammation and systemic metabolic pathologies in obesity are not entirely known. A…”
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Simple Precision Creation of Digitally Specified, Spatially Heterogeneous, Engineered Tissue Architectures by Gurkan, Umut Atakan, Fan, Yantao, Xu, Feng, Erkmen, Burcu, Urkac, Emel Sokullu, Parlakgul, Gunes, Bernstein, Jacob, Xing, Wangli, Boyden, Edward S., Demirci, Utkan

“…Complex architectures of integrated circuits are achieved through multiple layer photolithography, which has empowered the semiconductor industry. We adapt…”
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Chronic enrichment of hepatic endoplasmic reticulum–mitochondria contact leads to mitochondrial dysfunction in obesity by Arruda, Ana Paula, Pers, Benedicte M, Parlakgül, Güneş, Güney, Ekin, Inouye, Karen, Hotamisligil, Gökhan S

“…Obesity-induced mitochondria stress and dysfunction results from disorganized mitochondria-associated ER membranes and excess calcium flux. Proper function of…”
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Endoplasmic Reticulum Architecture and Inter-Organelle Communication in Metabolic Health and Disease by Arruda, Ana Paula, Parlakgül, Güneş

“…The endoplasmic reticulum (ER) is a key organelle involved in the regulation of lipid and glucose metabolism, proteostasis, Ca signaling, and detoxification…”
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Regulation of liver subcellular architecture controls metabolic homeostasis by Parlakgül, Güneş, Arruda, Ana Paula, Pang, Song, Cagampan, Erika, Min, Nina, Güney, Ekin, Lee, Grace Yankun, Inouye, Karen, Hess, Harald F., Xu, C. Shan, Hotamışlıgil, Gökhan S.

“…Cells display complex intracellular organization by compartmentalization of metabolic processes into organelles, yet the resolution of these structures in the…”
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Aberrant Ca 2+ signaling by IP 3 Rs in adipocytes links inflammation to metabolic dysregulation in obesity by Guney, Ekin, Arruda, Ana Paula, Parlakgul, Günes, Cagampan, Erika, Min, Nina, Lee, Grace Yankun, Greene, Lily, Tsaousidou, Eva, Inouye, Karen, Han, Myoung Sook, Davis, Roger J, Hotamisligil, Gökhan S

“…Chronic metabolic inflammation is a key feature of obesity, insulin resistance, and diabetes. Here, we showed that altered regulation of the Ca channel…”
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Spatial mapping of hepatic ER and mitochondria architecture reveals zonated remodeling in fasting and obesity by Parlakgül, Güneş, Pang, Song, Artico, Leonardo L., Min, Nina, Cagampan, Erika, Villa, Reyna, Goncalves, Renata L. S., Lee, Grace Yankun, Xu, C. Shan, Hotamışlıgil, Gökhan S., Arruda, Ana Paula

“…The hepatocytes within the liver present an immense capacity to adapt to changes in nutrient availability. Here, by using high resolution volume electron…”
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Defective STIM-mediated store operated Ca.sup.2+ entry in hepatocytes leads to metabolic dysfunction in obesity by Arruda, Ana Paula, Pers, Benedicte Mengel, Parlakgul, Günes, Güney, Ekin, Goh, Ted, Cagampan, Erika, Lee, Grace Yankun, Goncalves, Renata L, Hotamisligil, Gökhan S

“…Defective Ca.sup.2+ handling is a key mechanism underlying hepatic endoplasmic reticulum (ER) dysfunction in obesity. ER Ca.sup.2+ level is in part monitored…”
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Brown adipose tissue CoQ deficiency activates the integrated stress response and FGF21-dependent mitohormesis by Chang, Ching-Fang, Gunawan, Amanda L, Liparulo, Irene, Zushin, Peter-James H, Vitangcol, Kaitlyn, Timblin, Greg A, Saijo, Kaoru, Wang, Biao, Parlakgül, Güneş, Arruda, Ana Paula, Stahl, Andreas

“…Coenzyme Q (CoQ) is essential for mitochondrial respiration and required for thermogenic activity in brown adipose tissues (BAT). CoQ deficiency leads to a…”
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Defective STIM-mediated store operated Ca 2+ entry in hepatocytes leads to metabolic dysfunction in obesity by Arruda, Ana Paula, Pers, Benedicte Mengel, Parlakgul, Günes, Güney, Ekin, Goh, Ted, Cagampan, Erika, Lee, Grace Yankun, Goncalves, Renata L, Hotamisligil, Gökhan S

“…Defective Ca handling is a key mechanism underlying hepatic endoplasmic reticulum (ER) dysfunction in obesity. ER Ca level is in part monitored by the…”
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A 3 Year-Old Male Child Ingested Approximately 750 Grams of Elemental Mercury by Uysalol, Metin, Parlakgül, Güneş, Yılmaz, Yasin, Çıtak, Agop, Uzel, Nedret

“…The oral ingestion of elemental mercury is unlikely to cause systemic toxicity, as it is poorly absorbed through the gastrointestinal system. However, abnormal…”
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Sterol O-acyltransferase (SOAT/ACAT) activity is required to form cholesterol crystals in hepatocyte lipid droplets by Bairos, Jordan A., Njoku, Uche, Zafar, Maria, Akl, May G., Li, Lei, Parlakgul, Gunes, Arruda, Ana Paula, Widenmaier, Scott B.

“…Excess cholesterol storage can induce the formation of cholesterol crystals in hepatocyte lipid droplets. Such crystals distinguish metabolic dysfunction…”
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Integration of ER protein quality control mechanisms defines [beta] cell function and ER architecture by Shrestha, Neha, Torres, Mauricio, Zhang, Jason, Lu, You, Haataja, Leena, Reinert, Rachel B, Knupp, Jeffrey, Chen, Yu-Jie, Parlakgul, Gunes, Arruda, Ana Paula, Tsai, Billy, Arvan, Peter, Qi, Ling

“…Three principal ER quality-control mechanisms, namely, the unfolded protein response, ER-associated degradation (ERAD), and ER-phagy are each important for the…”
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Expression of regulatory receptors on γδ T cells and their cytokine production in Behcet's disease by Parlakgul, Gunes, Guney, Ekin, Erer, Burak, Kılıcaslan, Zeki, Direskeneli, Haner, Gul, Ahmet, Saruhan-Direskeneli, Guher

“…Behcet's disease (BD) is a multi-systemic disorder with muco-cutaneous, ocular, arthritic, vascular or central nervous system involvement. The role of γδ T…”
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Serum level of vitamin D and trace elements in children with recurrent wheezing: a cross-sectional study by Uysalol, Metin, Uysalol, Ezgi Pasli, Yilmaz, Yasin, Parlakgul, Gunes, Ozden, Tulin Ayse, Ertem, Hayriye Vehid, Omer, Beyhan, Uzel, Nedret

“…We aimed to show the relationship between recurrence of wheezing and serum levels of vitamin D, zinc, and copper in wheezy children compared with a healthy…”
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Clinical distuingishing characteristics and management of phyllodes tumors of the breast by Tukenmez, Mustafa, Kulle, Cemil Burak, Velidedeoglu, Mehmet, Agcaoglu, Orhan, Parlakgul, Gunes, Aydogan, Fatih, Onder, Semen, Bozdogan, Atilla, Ozkurt, Enver, Muslumanoglu, Mahmut, Igci, Abdullah, Dinccag, Ahmet, Ozmen, Vahit, Celik, Varol, Karanlik, Hasan, Fayda, Emre Merdan, Sen, Fatma, Aydiner, Adnan, Cabioglu, Neslihan

“…Abstract only…”
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Chronic enrichment of hepatic ER-mitochondria contact sites leads to calcium dependent mitochondrial dysfunction in obesity by Arruda, Ana Paula, Pers, Benedicte Mengel, Parlakgül, Güneş, Güney, Ekin, Inouye, Karen, Hotamisligil, Gökhan S.

“…Proper function of the endoplasmic reticulum (ER) and mitochondria is critical for cellular homeostasis, and dysfunction at either site has been linked to…”
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