Search Results - "Parkos, Charles A."

Inflammation and the Intestinal Barrier: Leukocyte–Epithelial Cell Interactions, Cell Junction Remodeling, and Mucosal Repair by Luissint, Anny-Claude, Parkos, Charles A, Nusrat, Asma

“…The intestinal tract is lined by a single layer of columnar epithelial cells that forms a dynamic, permeable barrier allowing for selective absorption of…”
Get full text

Pathobiology of neutrophil-epithelial interactions by Brazil, Jennifer C., Parkos, Charles A.

“…Summary Polymorphonuclear neutrophils (PMNs) are innate immune system cells that play an essential role in eradicating invading pathogens. PMN migration to…”
Get full text

Loss of Junctional Adhesion Molecule A Promotes Severe Steatohepatitis in Mice on a Diet High in Saturated Fat, Fructose, and Cholesterol by Rahman, Khalidur, Desai, Chirayu, Iyer, Smita S, Thorn, Natalie E, Kumar, Pradeep, Liu, Yunshan, Smith, Tekla, Neish, Andrew S, Li, Hongliang, Tan, Shiyun, Wu, Pengbo, Liu, Xiaoxiong, Yu, Yuanjie, Farris, Alton B, Nusrat, Asma, Parkos, Charles A, Anania, Frank A

“…Background & Aims There is evidence from clinical studies that compromised intestinal epithelial permeability contributes to the development of nonalcoholic…”
Get full text

Annexin A1-containing extracellular vesicles and polymeric nanoparticles promote epithelial wound repair by Leoni, Giovanna, Neumann, Philipp-Alexander, Kamaly, Nazila, Quiros, Miguel, Nishio, Hikaru, Jones, Hefin R, Sumagin, Ronen, Hilgarth, Roland S, Alam, Ashfaqul, Fredman, Gabrielle, Argyris, Ioannis, Rijcken, Emile, Kusters, Dennis, Reutelingsperger, Chris, Perretti, Mauro, Parkos, Charles A, Farokhzad, Omid C, Neish, Andrew S, Nusrat, Asma

“…Epithelial restitution is an essential process that is required to repair barrier function at mucosal surfaces following injury. Prolonged breaches in…”
Get full text

Compromised Intestinal Epithelial Barrier Induces Adaptive Immune Compensation that Protects from Colitis by Khounlotham, Manirath, Kim, Wooki, Peatman, Eric, Nava, Porfirio, Medina-Contreras, Oscar, Addis, Caroline, Koch, Stefan, Fournier, Benedicte, Nusrat, Asma, Denning, Timothy L., Parkos, Charles A.

“…Mice lacking junctional adhesion molecule A (JAM-A, encoded by F11r) exhibit enhanced intestinal epithelial permeability, bacterial translocation, and elevated…”
Get full text

Claudin-23 reshapes epithelial tight junction architecture to regulate barrier function by Raya-Sandino, Arturo, Lozada-Soto, Kristen M., Rajagopal, Nandhini, Garcia-Hernandez, Vicky, Luissint, Anny-Claude, Brazil, Jennifer C., Cui, Guiying, Koval, Michael, Parkos, Charles A., Nangia, Shikha, Nusrat, Asma

“…Claudin family tight junction proteins form charge- and size-selective paracellular channels that regulate epithelial barrier function. In the gastrointestinal…”
Get full text

JAM-related proteins in mucosal homeostasis and inflammation by Luissint, Anny-Claude, Nusrat, Asma, Parkos, Charles A.

“…Mucosal surfaces are lined by epithelial cells that form a physical barrier protecting the body against external noxious substances and pathogens. At a…”
Get full text

Epithelial CD47 is critical for mucosal repair in the murine intestine in vivo by Reed, Michelle, Luissint, Anny-Claude, Azcutia, Veronica, Fan, Shuling, O’Leary, Monique N., Quiros, Miguel, Brazil, Jennifer, Nusrat, Asma, Parkos, Charles A.

“…CD47 is a ubiquitously expressed transmembrane glycoprotein that regulates inflammatory responses and tissue repair. Here, we show that normal mice treated…”
Get full text

Cutting Edge: IL-36 Receptor Promotes Resolution of Intestinal Damage by Medina-Contreras, Oscar, Harusato, Akihito, Nishio, Hikaru, Flannigan, Kyle L, Ngo, Vu, Leoni, Giovanna, Neumann, Philipp-Alexander, Geem, Duke, Lili, Loukia N, Ramadas, Ravisankar A, Chassaing, Benoit, Gewirtz, Andrew T, Kohlmeier, Jacob E, Parkos, Charles A, Towne, Jennifer E, Nusrat, Asma, Denning, Timothy L

“…IL-1 family members are central mediators of host defense. In this article, we show that the novel IL-1 family member IL-36γ was expressed during experimental…”
Get full text

The role of polymorphonuclear leukocyte trafficking in the perpetuation of inflammation during inflammatory bowel disease by Brazil, Jennifer C, Louis, Nancy A, Parkos, Charles A

“…The inflammatory bowel diseases (IBDs; Crohn's disease, and ulcerative colitis) are chronically relapsing inflammatory disorders of the intestine and/or colon…”
Get full text

Formyl peptide receptor 2 regulates monocyte recruitment to promote intestinal mucosal wound repair by Birkl, Dorothee, O'Leary, Monique N., Quiros, Miguel, Azcutia, Veronica, Schaller, Matthew, Reed, Michelle, Nishio, Hikaru, Keeney, Justin, Neish, Andrew S., Lukacs, Nicholas W., Parkos, Charles A., Nusrat, Asma

“…Mucosal wound repair is coordinated by dynamic crosstalk between endogenous and exogenous mediators and specific receptors on epithelial cells and infiltrating…”
Get full text

Role of JAM-A tyrosine phosphorylation in epithelial barrier dysfunction during intestinal inflammation by Fan, Shuling, Weight, Caroline M, Luissint, Anny-Claude, Hilgarth, Roland S, Brazil, Jennifer C, Ettel, Mark, Nusrat, Asma, Parkos, Charles A

“…Junctional adhesion molecule-A (JAM-A), an epithelial tight junction protein, plays an important role in regulating intestinal permeability through association…”
Get full text

Western diet‐induced increase in colonic bile acids compromises epithelial barrier in nonalcoholic steatohepatitis by Gupta, Biki, Liu, Yunshan, Chopyk, Daniel M., Rai, Ravi P., Desai, Chirayu, Kumar, Pradeep, Farris, Alton B., Nusrat, Asma, Parkos, Charles A., Anania, Frank A., Raeman, Reben

“…There is compelling evidence implicating intestinal permeability in the pathogenesis of nonalcoholic steatohepatitis (NASH), but the underlying mechanisms…”
Get full text

JAM-A regulates permeability and inflammation in the intestine in vivo by Laukoetter, Mike G, Nava, Porfirio, Lee, Winston Y, Severson, Eric A, Capaldo, Christopher T, Babbin, Brian A, Williams, Ifor R, Koval, Michael, Peatman, Eric, Campbell, Jacquelyn A, Dermody, Terence S, Nusrat, Asma, Parkos, Charles A

“…Recent evidence has linked intestinal permeability to mucosal inflammation, but molecular studies are lacking. Candidate regulatory molecules localized within…”
Get full text

SIRPα - CD47 axis regulates dendritic cell-T cell interactions and TCR activation during T cell priming in spleen by Autio, Anu, Wang, Huan, Velázquez, Francisco, Newton, Gail, Parkos, Charles A, Engel, Pablo, Engelbertsen, Daniel, Lichtman, Andrew H, Luscinskas, Francis W

“…The SIRPα-CD47 axis plays an important role in T cell recruitment to sites of immune reaction and inflammation but its role in T cell antigen priming is…”
Get full text

Inflammation-induced desmoglein-2 ectodomain shedding compromises the mucosal barrier by Kamekura, Ryuta, Nava, Porfirio, Feng, Mingli, Quiros, Miguel, Nishio, Hikaru, Weber, Dominique A, Parkos, Charles A, Nusrat, Asma

“…Desmosomal cadherins mediate intercellular adhesion and control epithelial homeostasis. Recent studies show that proteinases play an important role in the…”
Get full text

The Wnt Antagonist Dkk1 Regulates Intestinal Epithelial Homeostasis and Wound Repair by Koch, Stefan, Nava, Porfirio, Addis, Caroline, Kim, Wooki, Denning, Timothy L, Li, Linheng, Parkos, Charles A, Nusrat, Asma

“…Background & Aims Dkk1 is a secreted antagonist of the Wnt/β-catenin signaling pathway. It is induced by inflammatory cytokines during colitis and exacerbates…”
Get full text

Intracellular mediators of JAM-A-dependent epithelial barrier function by Monteiro, Ana C., Parkos, Charles A.

“…Junctional adhesion molecule‐A (JAM‐A) is a critical signaling component of the apical junctional complex, a structure composed of several transmembrane and…”
Get full text

TLR Signaling Mediated by MyD88 Is Required for a Protective Innate Immune Response by Neutrophils to Citrobacter rodentium by Lebeis, Sarah L, Bommarius, Bettina, Parkos, Charles A, Sherman, Melanie A, Kalman, Daniel

“…Enteropathogenic Escherichia coli, enterohemorrhagic E. coli, and Citrobacter rodentium are classified as attaching and effacing pathogens based on their…”
Get full text

Proinflammatory Cytokines Disrupt Epithelial Barrier Function by Apoptosis-Independent Mechanisms by Bruewer, Matthias, Luegering, Andreas, Kucharzik, Torsten, Parkos, Charles A, Madara, James L, Hopkins, Ann M, Nusrat, Asma

“…It is well known that inflammatory conditions of the intestinal mucosa result in compromised barrier function. Inflammation is characterized by an influx into…”
Get full text