Search Results - "Parkkila, Seppo"

Bioinformatic characterization of angiotensin-converting enzyme 2, the entry receptor for SARS-CoV-2 by Barker, Harlan, Parkkila, Seppo

“…The World Health Organization declared the COVID-19 epidemic a public health emergency of international concern on March 11th, 2020, and the pandemic is…”
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Roles of Carbonic Anhydrases and Carbonic Anhydrase Related Proteins in Zebrafish by Aspatwar, Ashok, Syrjänen, Leo, Parkkila, Seppo

“…During recent decades, zebrafish ( ) have become one of the most important model organisms in which to study different physiological and biological phenomena…”
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Crystal Structure of the Catalytic Domain of the Tumor-Associated Human Carbonic Anhydrase IX by Alterio, Vincenzo, Hilvo, Mika, Di Fiore, Anna, Supuran, Claudiu T., Pan, Peiwen, Parkkila, Seppo, Scaloni, Andrea, Pastorek, Jaromir, Pastorekova, Silvia, Pedone, Carlo, Scozzafava, Andrea, Monti, Simona Maria, De Simone, Giuseppina, Sly, William S.

“…Carbonic anhydrase (CA) IX is a plasma membrane-associated member of the α-CA enzyme family, which is involved in solid tumor acidification. It is a marker of…”
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Inhibition studies of the protozoan α-carbonic anhydrase from Trypanosoma cruzi with phenols by Bonardi, Alessandro, Parkkila, Seppo, Supuran, Claudiu T.

“…The α-class carbonic anhydrase (CA, EC 4.2.1.1) from the protozoan pathogen Trypanosoma cruzi, TcCA, was investigated earlier for its inhibition with anions,…”
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Phytochemicals as Modulators of Long Non-Coding RNAs and Inhibitors of Cancer-Related Carbonic Anhydrases by Saghafi, Tayebeh, Taheri, Ramezan Ali, Parkkila, Seppo, Emameh, Reza Zolfaghari

“…Long non-coding RNAs (lncRNAs) are classified as a group of transcripts which regulate various biological processes, such as RNA processing, epigenetic…”
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Inhibition Studies on Human and Mycobacterial Carbonic Anhydrases with N -((4-Sulfamoylphenyl)carbamothioyl) Amides by Abdoli, Morteza, Bonardi, Alessandro, Paoletti, Niccolò, Aspatwar, Ashok, Parkkila, Seppo, Gratteri, Paola, Supuran, Claudiu T, Žalubovskis, Raivis

“…A library of structurally diverse -((4-sulfamoylphenyl)carbamothioyl) amides was synthesized by selective acylation of easily accessible…”
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Mycobacterium tuberculosis β -Carbonic Anhydrases: Novel Targets for Developing Antituberculosis Drugs by Aspatwar, Ashok, Kairys, Visvaldas, Rala, Sangeetha, Parikka, Mataleena, Bozdag, Murat, Carta, Fabrizio, Supuran, Claudiu T, Parkkila, Seppo

“…The genome of ( ) encodes three -carbonic anhydrases (CAs, EC 4.2.1.1) that are crucial for the life cycle of the bacterium. The -CAs have been cloned and…”
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Assessment of databases to determine the validity of β- and γ-carbonic anhydrase sequences from vertebrates by Zolfaghari Emameh, Reza, Kuuslahti, Marianne, Nosrati, Hassan, Lohi, Hannes, Parkkila, Seppo

“…The inaccuracy of DNA sequence data is becoming a serious problem, as the amount of molecular data is multiplying rapidly and expectations are high for big…”
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Brucellosis: epidemiology, pathogenesis, diagnosis and treatment-a comprehensive review by Qureshi, Kamal A, Parvez, Adil, Fahmy, Nada A, Abdel Hady, Bassant H, Kumar, Shweta, Ganguly, Anusmita, Atiya, Akhtar, Elhassan, Gamal O, Alfadly, Saeed O, Parkkila, Seppo, Aspatwar, Ashok

“…Brucellosis is a pervasive zoonotic disease caused by various species. It mainly affects livestock and wildlife and poses significant public health threats,…”
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Activation studies with amino acids and amines of a β-carbonic anhydrase from Mammaliicoccus (Staphylococcus) sciuri previously annotated as Staphylococcus aureus (SauBCA) carbonic anhydrase by Angeli, Andrea, Urbański, Linda J, Capasso, Clemente, Parkkila, Seppo, Supuran, Claudiu T.

“…A β-carbonic anhydrase (CA, EC 4.2.1.1) previously annotated to be present in the genome of Staphylococcus aureus, SauBCA, has been shown to belong to another…”
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Cloning, characterization, and inhibition of the novel β-carbonic anhydrase from parasitic blood fluke, Schistosoma mansoni by Haapanen, Susanna, Angeli, Andrea, Tolvanen, Martti, Emameh, Reza Zolfaghari, Supuran, Claudiu T., Parkkila, Seppo

“…Schistosoma mansoni is an intestinal parasite with one β-class carbonic anhydrase, SmaBCA. We report the sequence enhancing, production, catalytic activity,…”
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Carbonic Anhydrase Inhibitors as Novel Drugs against Mycobacterial β-Carbonic Anhydrases: An Update on In Vitro and In Vivo Studies by Aspatwar, Ashok, Winum, Jean-Yves, Carta, Fabrizio, Supuran, Claudiu T, Hammaren, Milka, Parikka, Mataleena, Parkkila, Seppo

“…Mycobacteria cause a variety of diseases, such as tuberculosis, leprosy, and opportunistic diseases in immunocompromised people. The treatment of these…”
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An Update on the Metabolic Roles of Carbonic Anhydrases in the Model Alga Chlamydomonas reinhardtii by Aspatwar, Ashok, Haapanen, Susanna, Parkkila, Seppo

“…Carbonic anhydrases (CAs) are metalloenzymes that are omnipresent in nature. CAs catalyze the basic reaction of the reversible hydration of CO₂ to HCO₃ and H⁺…”
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The role of carbonic anhydrase VI in bitter taste perception: evidence from the Car6⁻/⁻ mouse model by Patrikainen, Maarit, Pan, Peiwen, Kulesskaya, Natalia, Voikar, Vootele, Parkkila, Seppo

“…Carbonic anhydrase VI (CA VI) is a secretory isozyme of the α-CA gene family. It is highly expressed in the salivary and mammary glands and secreted into…”
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An anion and small molecule inhibition study of the β-carbonic anhydrase from Staphylococcus aureus by Urbanski, Linda J., Vullo, Daniela, Parkkila, Seppo, Supuran, Claudiu T.

“…Pathogenic bacteria resistant to most antibiotics, including the methicillin-resistant Staphylococcus aureus (MRSA) represent a serious medical problem. The…”
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Carbonic anhydrase enzymes Ⅱ, Ⅶ, Ⅸ and Ⅻ in colorectal carcinomas by Viikilä, Pia, Kivelä, Antti J, Mustonen, Harri, Koskensalo, Selja, Waheed, Abdul, Sly, William S, Pastorek, Jaromir, Pastorekova, Silvia, Parkkila, Seppo, Haglund, Caj

“…AIM To investigate expression of four alpha-carbonic anhydrases(CAs) in colorectal carcinomas(CRC) and compare the results with patients’ survival.METHODS…”
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Design, Synthesis, and Evaluation of Hydroxamic Acid Derivatives as Promising Agents for the Management of Chagas Disease by Rodrigues, Giseli Capaci, Feijó, Daniel Ferreira, Bozza, Marcelo Torres, Pan, Peiwen, Vullo, Daniela, Parkkila, Seppo, Supuran, Claudiu T., Capasso, Clemente, Aguiar, Alcino Palermo, Vermelho, Alane Beatriz

“…Today, there are approximately 8 million cases of Chagas disease in the southern cone of South America alone, and about 100 million people are living with the…”
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Cloning, Characterization and Anion Inhibition Studies of a β-Carbonic Anhydrase from the Pathogenic Protozoan Entamoeba histolytica by Haapanen, Susanna, Bua, Silvia, Kuuslahti, Marianne, Parkkila, Seppo, Supuran, Claudiu T

“…We report the cloning and catalytic activity of a β-carbonic anhydrase (CA, EC 4.2.1.1), isolated from the pathogenic protozoan , EhiCA. This enzyme has a high…”
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Navigating bioactivity space in anti-tubercular drug discovery through the deployment of advanced machine learning models and cheminformatics tools: a molecular modeling based retrospective study by Bhowmik, Ratul, Kant, Ravi, Manaithiya, Ajay, Saluja, Daman, Vyas, Bharti, Nath, Ranajit, Qureshi, Kamal A, Parkkila, Seppo, Aspatwar, Ashok

“…is the bacterial strain that causes tuberculosis (TB). However, multidrug-resistant and extensively drug-resistant tuberculosis are significant obstacles to…”
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A reverse vaccinology approach on transmembrane carbonic anhydrases from Plasmodium species as vaccine candidates for malaria prevention by Zolfaghari Emameh, Reza, Barker, Harlan R, Turpeinen, Hannu, Parkkila, Seppo, Hytönen, Vesa P

“…Malaria is a significant parasitic infection, and human infection is mediated by mosquito (Anopheles) biting and subsequent transmission of protozoa…”
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