Search Results - "Parkinson's disease"

Plasma Prolidase Activity and Oxidative Stress in Patients with Parkinson's Disease by Srivastava, Shalabh, Singh, Tej Bali, Sharma, Vivek, Raj, Janak, Verma, Akhilesh Kumar, Srivastava, Ragini

“…Prolidase deficiency has been related to mental retardation and oxidative stress. The study aimed to observe plasma prolidase activity (PPA), total oxidant…”
Get full text

Pathophysiology of Motor Dysfunction in Parkinson's Disease as the Rationale for Drug Treatment and Rehabilitation by Tamburin, Stefano, Smania, Nicola, Roncari, Laura, Federico, Angela, Tocco, Pierluigi, Picelli, Alessandro, Magrinelli, Francesca, Zanette, Giampietro

“…Cardinal motor features of Parkinson’s disease (PD) include bradykinesia, rest tremor, and rigidity, which appear in the early stages of the disease and…”
Get full text

Alpha-Synuclein in Parkinson's Disease: From Pathogenetic Dysfunction to Potential Clinical Application by Xu, Lingjia, Pu, Jiali

“…Parkinson’s disease is a neurodegenerative disease/synucleinopathy that develops slowly; however, there is no efficient method of early diagnosis, nor is there…”
Get full text

Cognition Deficits in Parkinson’s Disease: Mechanisms and Treatment by Dong, Huimin, Mao, Shanping, Lv, Longqin, Fang, Congcong, Liu, Baohui

“…Parkinson’s disease (PD) is the second most common progressive neurodegenerative disorder mainly in middle-elderly population, which represents diverse…”
Get full text

The Synucleinopathies: Twenty Years On by Goedert, Michel, Jakes, Ross, Spillantini, Maria Grazia

“…In 2017, it is two hundred years since James Parkinson provided the first complete clinical description of the disease named after him, fifty years since the…”
Get more information

Recurrent Falls in Parkinson’s Disease: A Systematic Review by Allen, Natalie E., Canning, Colleen G., Schwarzel, Allison K.

“…Most people with Parkinson’s disease (PD) fall and many experience recurrent falls. The aim of this review was to examine the scope of recurrent falls and to…”
Get full text

The Synaptic Function of α-Synuclein by Burré, Jacqueline

“…α-Synuclein is an abundant neuronal protein which localizes predominantly to presynaptic terminals, and is strongly linked genetically and pathologically to…”
Get more information

The MPTP Story by Langston, J William

Get more information

The role of oxidative stress in Parkinson's disease by Dias, Vera, Junn, Eunsung, Mouradian, M Maral

“…Oxidative stress plays an important role in the degeneration of dopaminergic neurons in Parkinson's disease (PD). Disruptions in the physiologic maintenance of…”
Get more information

Meta-analysis of the Parkinson’s disease gut microbiome suggests alterations linked to intestinal inflammation by Romano, Stefano, Savva, George M., Bedarf, Janis R., Charles, Ian G., Hildebrand, Falk, Narbad, Arjan

“…The gut microbiota is emerging as an important modulator of neurodegenerative diseases, and accumulating evidence has linked gut microbes to Parkinson’s…”
Get full text

Neuropathological Staging of Brain Pathology in Sporadic Parkinson's disease: Separating the Wheat from the Chaff by Braak, Heiko, Del Tredici, Kelly

“…A relatively small number of especially susceptible nerve cell types within multiple neurotransmitter systems of the human central, peripheral, and enteric…”
Get more information

A Review of Dual-Task Walking Deficits in People with Parkinson's Disease: Motor and Cognitive Contributions, Mechanisms, and Clinical Implications by Kelly, Valerie E., Eusterbrock, Alexis J., Shumway-Cook, Anne

“…Gait impairments in Parkinson's disease (PD) are exacerbated under dual-task conditions requiring the simultaneous performance of cognitive or motor tasks…”
Get full text

Monoamine Oxidase-B Inhibitors for the Treatment of Parkinson's Disease: Past, Present, and Future by Tan, Yu-Yan, Jenner, Peter, Chen, Sheng-Di

“…Monoamine oxidase-B (MAO-B) inhibitors are commonly used for the symptomatic treatment of Parkinson's disease (PD). MAO-B inhibitor monotherapy has been shown…”
Get more information

The Sources of Reactive Oxygen Species and Its Possible Role in the Pathogenesis of Parkinson’s Disease by Zhang, Cheng-wu, Lim, Kah-Leong, Liu, Chao, Xie, Xiaoji, Weng, Minrui, Li, Lin

“…Parkinson’s disease (PD) is the second most common neurodegenerative disorder characterized by progressive loss of dopaminergic neurons in the substantia…”
Get full text

Prevalence of Parkinson’s disease across North America by Marras, C., Beck, J. C., Bower, J. H., Roberts, E., Ritz, B, Ross, G. W., Abbott, R. D., Savica, R., Van Den Eeden, S. K., Willis, A. W., Tanner, CM

“…Estimates of the prevalence of Parkinson’s disease in North America have varied widely and many estimates are based on small numbers of cases and from small…”
Get full text

Current and projected future economic burden of Parkinson’s disease in the U.S by Yang, Wenya, Hamilton, Jamie L., Kopil, Catherine, Beck, James C., Tanner, Caroline M., Albin, Roger L., Ray Dorsey, E., Dahodwala, Nabila, Cintina, Inna, Hogan, Paul, Thompson, Ted

“…Parkinson’s disease (PD) is one of the world’s fastest growing neurological disorders. Much is unknown about PD-associated economic burdens in the United…”
Get full text

The Impact of the COVID-19 Pandemic on Parkinson's Disease: Hidden Sorrows and Emerging Opportunities by Helmich, Rick C, Bloem, Bastiaan R

Get more information

The Role of Lipids Interacting with α-Synuclein in the Pathogenesis of Parkinson's Disease by Galvagnion, Céline

“…α-synuclein is a small protein abundantly expressed in the brain and mainly located in synaptic terminals. The conversion of α-synuclein into oligomers and…”
Get more information

Implication of Alpha-Synuclein Phosphorylation at S129 in Synucleinopathies: What Have We Learned in the Last Decade? by Oueslati, Abid

“…Abnormal accumulation of proteinaceous intraneuronal inclusions called Lewy bodies (LBs) is the neurpathological hallmark of Parkinson's disease (PD) and…”
Get more information

Gastrointestinal Dysfunctions in Parkinson's Disease: Symptoms and Treatments by Di Paolo, Thérèse, Morin, Nicolas, Côté, Mélissa, Aubé, Benoit, Poirier, Andrée-Anne, Soulet, Denis

“…A diagnosis of Parkinson’s disease is classically established after the manifestation of motor symptoms such as rigidity, bradykinesia, and tremor. However, a…”
Get full text