Search Results - "Parkins, Michael D"

Epidemiology, Biology, and Impact of Clonal Pseudomonas aeruginosa Infections in Cystic Fibrosis by Parkins, Michael D, Somayaji, Ranjani, Waters, Valerie J

“…Chronic lower airway infection with is a major contributor to morbidity and mortality in individuals suffering from the genetic disease cystic fibrosis (CF)…”
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Systematic review: cystic fibrosis in the SARS-CoV-2/COVID-19 pandemic by Mathew, Hannah R, Choi, May Y, Parkins, Michael D, Fritzler, Marvin J

“…Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and the development of life-threatening COVID-19 are believed to disproportionately…”
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Longitudinal sampling of the lung microbiota in individuals with cystic fibrosis by Whelan, Fiona J, Heirali, Alya A, Rossi, Laura, Rabin, Harvey R, Parkins, Michael D, Surette, Michael G

“…Cystic fibrosis (CF) manifests in the lungs resulting in chronic microbial infection. Most morbidity and mortality in CF is due to cycles of pulmonary…”
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Phenotypic heterogeneity of Pseudomonas aeruginosa populations in a cystic fibrosis patient by Workentine, Matthew L, Sibley, Christopher D, Glezerson, Bryan, Purighalla, Swathi, Norgaard-Gron, Jens C, Parkins, Michael D, Rabin, Harvey R, Surette, Michael G

“…The opportunistic pathogen Pseudomonas aeruginosa chronically infects the lower airways of patients with cystic fibrosis. Throughout the course of infection…”
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Epidemiology and risk factors for pyogenic liver abscess in the Calgary Health Zone revisited: a population-based study by Losie, Jennifer A, Lam, John C, Gregson, Daniel B, Parkins, Michael D

“…Abstract Background Pyogenic liver abscess (PLA), although uncommon in North America, is associated with significant morbidity and mortality. We sought to…”
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Culture enriched molecular profiling of the cystic fibrosis airway microbiome by Sibley, Christopher D, Grinwis, Margot E, Field, Tyler R, Eshaghurshan, Christina S, Faria, Monica M, Dowd, Scot E, Parkins, Michael D, Rabin, Harvey R, Surette, Michael G

“…The microbiome of the respiratory tract, including the nasopharyngeal and oropharyngeal microbiota, is a dynamic community of microorganisms that is highly…”
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Chronic hepatitis E: an important entity for clinicians to be aware of by Congly, Stephen E, Parkins, Michael D, Doucette, Karen E

“…Congly et al assert that although hepatitis E is predominantly an acute, self-limited infection with uncommon cases of liver failure, chronic hepatitis E…”
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polymicrobial perspective of pulmonary infections exposes an enigmatic pathogen in cystic fibrosis patients by Sibley, Christopher D, Parkins, Michael D, Rabin, Harvey R, Duan, Kangmin, Norgaard, Jens C, Surette, Michael G

“…Lung disease is the leading cause of morbidity and mortality in cystic fibrosis (CF) patients. A modest number of bacterial pathogens have been correlated with…”
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Incidence, susceptibility and outcomes of candidemia in adults living in Calgary, Alberta, Canada (2010-2018) by Bourassa-Blanchette, Samuel, Biesheuvel, Marit M, Lam, John C, Kipp, Alexander, Church, Deirdre, Carson, Julie, Dalton, Bruce, Parkins, Michael D, Barkema, Herman W, Gregson, Daniel B

“…Candidemia is increasing in frequency and is associated with high mortality. We sought to determine the burden of illness, the population it affects and its…”
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Azithromycin and the microbiota of cystic fibrosis sputum by Acosta, Nicole, Thornton, Christina S, Surette, Michael G, Somayaji, Ranjani, Rossi, Laura, Rabin, Harvey R, Parkins, Michael D

“…Azithromycin is commonly prescribed drug for individuals with cystic fibrosis (CF), with demonstrated benefits in reducing lung function decline, exacerbation…”
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Discerning the complexity of community interactions using a Drosophila model of polymicrobial infections by Sibley, Christopher D, Duan, Kangmin, Fischer, Carrie, Parkins, Michael D, Storey, Douglas G, Rabin, Harvey R, Surette, Michael G

“…A number of human infections are characterized by the presence of more than one bacterial species and are defined as polymicrobial diseases. Methods for the…”
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The Evolving Cystic Fibrosis Microbiome: A Comparative Cohort Study Spanning 16 Years by Acosta, Nicole, Whelan, Fiona J, Somayaji, Ranjani, Poonja, Ali, Surette, Michael G, Rabin, Harvey R, Parkins, Michael D

“…The cystic fibrosis (CF) airways are infected with a diverse polymicrobial community. Understanding how changes in the CF microbiome have occurred over time,…”
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Incidence and Risk Factors for Pulmonary Exacerbation Treatment Failures in Patients With Cystic Fibrosis Chronically Infected With Pseudomonas aeruginosa by Parkins, Michael D., MD, Rendall, Jacqueline C., MD, Elborn, J. Stuart, MD, PhD

“…Background Pulmonary exacerbations (PEx) are responsible for much of the morbidity and mortality associated with cystic fibrosis (CF). However, there is a…”
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Clinical epidemiology and impact of Haemophilus influenzae airway infections in adults with cystic fibrosis by Weyant, R Benson, Waddell, Barbara J, Acosta, Nicole, Izydorczyk, Conrad, Conly, John M, Church, Deirdre L, Surette, Michael G, Rabin, Harvey R, Thornton, Christina S, Parkins, Michael D

“…Haemophilus influenzae is prevalent within the airways of persons with cystic fibrosis (pwCF). H. influenzae is often associated with pulmonary exacerbations…”
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The natural history and genetic diversity of Haemophilus influenzae infecting the airways of adults with cystic fibrosis by Izydorczyk, Conrad, Waddell, Barbara J., Weyant, Robert B., Surette, Michael G., Somayaji, Ranjani, Rabin, Harvey R., Conly, John M., Church, Deirdre L., Parkins, Michael D.

“…Haemophilus influenzae is a Gram-negative pathobiont, frequently recovered from the airways of persons with cystic fibrosis (pwCF). Previous studies of H…”
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Stenotrophomonas maltophilia natural history and evolution in the airways of adults with cystic fibrosis by Izydorczyk, Conrad, Waddell, Barbara J, Thornton, Christina S, Conly, John M, Rabin, Harvey R, Somayaji, Ranjani, Surette, Michael G, Church, Deirdre L, Parkins, Michael D

“…is an opportunistic pathogen infecting persons with cystic fibrosis (pwCF) and portends a worse prognosis. Studies of infection dynamics have been limited by…”
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The airway microbiome of persons with cystic fibrosis correlates with acquisition and microbiological outcomes of incident Stenotrophomonas maltophilia infection by Bowron, Lauren A, Acosta, Nicole, Thornton, Christina S, Carpentero, Jennifer, Waddell, Barbara-Jean M, Bharadwaj, Lalit, Ebbert, Kirsten, Castañeda-Mogollón, Daniel, Conly, John M, Rabin, Harvey R, Surette, Michael G, Parkins, Michael D

“…Chronic infection with in persons with cystic fibrosis (pwCF) has been linked to an increased risk of pulmonary exacerbations and lung function decline. We…”
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Specificity in the Susceptibilities of Escherichia coli , Pseudomonas aeruginosa and Staphylococcus aureus Clinical Isolates to Six Metal Antimicrobials by Gugala, Natalie, Vu, Dennis, Parkins, Michael D, Turner, Raymond J

“…In response to the occurrence of antibiotic resistance, there has been rapid developments in the field of metal-based antimicrobials. Although it is largely…”
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Assessment of the Microbial Constituents of the Home Environment of Individuals with Cystic Fibrosis (CF) and Their Association with Lower Airways Infections by Heirali, Alya, McKeon, Suzanne, Purighalla, Swathi, Storey, Douglas G, Rossi, Laura, Costilhes, Geoffrey, Drews, Steven J, Rabin, Harvey R, Surette, Michael G, Parkins, Michael D

“…Cystic fibrosis (CF) airways are colonized by a polymicrobial community of organisms, termed the CF microbiota. We sought to define the microbial constituents…”
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The effects of inhaled aztreonam on the cystic fibrosis lung microbiome by Heirali, Alya A, Workentine, Matthew L, Acosta, Nicole, Poonja, Ali, Storey, Douglas G, Somayaji, Ranjani, Rabin, Harvey R, Whelan, Fiona J, Surette, Michael G, Parkins, Michael D

“…Aztreonam lysine for inhalation (AZLI) is an inhaled antibiotic used to treat chronic Pseudomonas aeruginosa infection in CF. AZLI improves lung function and…”
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