Search Results - "Parkes, Shauna L"
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Incentive memory: evidence the basolateral amygdala encodes and the insular cortex retrieves outcome values to guide choice between goal-directed actions
Published in The Journal of neuroscience (15-05-2013)“…Choice between goal-directed actions is determined by the relative value of their consequences. Such values are encoded during incentive learning and later…”
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Insular and Ventrolateral Orbitofrontal Cortices Differentially Contribute to Goal-Directed Behavior in Rodents
Published in Cerebral cortex (New York, N.Y. 1991) (01-07-2018)“…Abstract The medial prefrontal cortex (mPFC) has long been considered a critical site in action control. However, recent evidence indicates that the…”
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Interaction of insular cortex and ventral striatum mediates the effect of incentive memory on choice between goal-directed actions
Published in The Journal of neuroscience (22-04-2015)“…The anterior insular cortex (IC) and the nucleus accumbens (NAc) core have been separately implicated in the selection and performance of actions based on the…”
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4
A thalamocortical circuit for updating action-outcome associations
Published in eLife (23-04-2019)“…The ability to flexibly use knowledge is one cardinal feature of goal-directed behaviors. We recently showed that thalamocortical and corticothalamic pathways…”
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Inhibition of noradrenergic signalling in rodent orbitofrontal cortex impairs the updating of goal-directed actions
Published in eLife (20-02-2023)“…In a constantly changing environment, organisms must track the current relationship between actions and their specific consequences and use this information to…”
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Switching Adolescent High-Fat Diet to Adult Control Diet Restores Neurocognitive Alterations
Published in Frontiers in behavioral neuroscience (21-11-2016)“…In addition to metabolic and cardiovascular disorders, obesity is associated with adverse cognitive and emotional outcomes. Its growing prevalence in…”
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Targeting Reciprocally Connected Brain Regions Through CAV-2 Mediated Interventions
Published in Frontiers in molecular neuroscience (10-12-2019)“…An important issue in contemporary neuroscience is to identify functional principles at play within neural circuits. The reciprocity of the connections between…”
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A hippocampo-cortical pathway detects changes in the validity of an action as a predictor of reward
Published in Current biology (08-01-2024)“…Much research has been dedicated to understanding the psychological and neural bases of goal-directed action, yet the relationship between context and…”
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Contribution of dorsal versus ventral hippocampus to the hierarchical modulation of goal‐directed actions in rats
Published in The European journal of neuroscience (01-10-2023)“…Adaptive behaviour often necessitates that animals learn about events in a manner that is specific to a particular context or environment. These hierarchical…”
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Prefrontal regulation of behavioural control: Evidence from learning theory and translational approaches in rodents
Published in Neuroscience and biobehavioral reviews (01-11-2020)“…•Action control is measured by goal-directed learning & impulsive/compulsive behavioural tasks.•Cortical regions have been implicated in various aspects of…”
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Dopamine and Noradrenaline Modulation of Goal-Directed Behavior in Orbital and Medial Prefrontal Cortex: Toward a Division of Labor?
Published in Behavioral neuroscience (01-04-2021)“…The prefrontal cortex is considered to be at the core of goal-directed behaviors. Notably, the medial prefrontal cortex (mPFC) is known to play an important…”
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The effect of high-fat diet consumption on appetitive instrumental behavior in rats
Published in Appetite (01-01-2017)“…Evidence now indicates that the chronic consumption of high-calorie foods, such as a high-fat diet (HFD), is associated with impaired control over…”
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Acquisition of specific response–outcome associations requires NMDA receptor activation in the basolateral amygdala but not in the insular cortex
Published in Neurobiology of learning and memory (01-02-2016)“…•We examine the acquisition of specific response–outcome (R–O) associations.•BLA NMDA receptor activation is required for the acquisition of R–O…”
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The basolateral amygdala is critical for the acquisition and extinction of associations between a neutral stimulus and a learned danger signal but not between two neutral stimuli
Published in The Journal of neuroscience (22-09-2010)“…We studied the neural substrates of higher-order conditioned fear in rats. We first studied acquisition and extinction of second-order fear. One stimulus (S1)…”
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A time course analysis of satiety-induced instrumental outcome devaluation
Published in Learning & behavior (01-12-2016)“…Sensory-specific satiety is commonly used in studies of decision making to selectively devalue a food reward. Devaluation is reflected in an immediate…”
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The basolateral amygdala is critical for learning about neutral stimuli in the presence of danger, and the perirhinal cortex is critical in the absence of danger
Published in The Journal of neuroscience (07-08-2013)“…The perirhinal cortex (PRh) and basolateral amygdala (BLA) appear to mediate distinct aspects of learning and memory. Here, we used rats to investigate the…”
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Microglial activation enhances associative taste memory through purinergic modulation of glutamatergic neurotransmission
Published in The Journal of neuroscience (18-02-2015)“…The cerebral innate immune system is able to modulate brain functioning and cognitive processes. During activation of the cerebral innate immune system,…”
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Intermittent feeding alters sensitivity to changes in reward value
Published in Appetite (01-06-2017)“…The influence of binge-like feeding schedules on subsequent food-related behavior is not well understood. We investigated the effect of repeated cycles of…”
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Differential role of insular cortex muscarinic and NMDA receptors in one-trial appetitive taste learning
Published in Neurobiology of learning and memory (01-12-2014)“…•We examined the role of the insular cortex in appetitive and aversive taste memory.•We used a one trial appetitive taste learning task.•Insular cortex…”
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Role of the basolateral amygdala and NMDA receptors in higher-order conditioned fear
Published in Reviews in the neurosciences (01-01-2011)“…Laboratory rats learn to fear relatively innocuous stimuli which signal the imminent arrival of an innate source of danger, typically brief but aversive foot…”
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