Search Results - "Parker Wilson"

Cell profiling of mouse acute kidney injury reveals conserved cellular responses to injury by Kirita, Yuhei, Wu, Haojia, Uchimura, Kohei, Wilson, Parker C., Humphreys, Benjamin D.

“…After acute kidney injury (AKI), patients either recover or alternatively develop fibrosis and chronic kidney disease. Interactions between injured epithelia,…”
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Single cell transcriptional and chromatin accessibility profiling redefine cellular heterogeneity in the adult human kidney by Muto, Yoshiharu, Wilson, Parker C., Ledru, Nicolas, Wu, Haojia, Dimke, Henrik, Waikar, Sushrut S., Humphreys, Benjamin D.

“…The integration of single cell transcriptome and chromatin accessibility datasets enables a deeper understanding of cell heterogeneity. We performed single…”
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The single-cell transcriptomic landscape of early human diabetic nephropathy by Wilson, Parker C., Wu, Haojia, Kirita, Yuhei, Uchimura, Kohei, Ledru, Nicolas, Rennke, Helmut G., Welling, Paul A., Waikar, Sushrut S., Humphreys, Benjamin D.

“…Diabetic nephropathy is characterized by damage to both the glomerulus and tubulointerstitium, but relatively little is known about accompanying cell-specific…”
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Spatially Resolved Transcriptomic Analysis of Acute Kidney Injury in a Female Murine Model by Dixon, Eryn E, Wu, Haojia, Muto, Yoshiharu, Wilson, Parker C, Humphreys, Benjamin D

“…Single-cell sequencing technologies have advanced our understanding of kidney biology and disease, but the loss of spatial information in these datasets…”
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Multimodal single cell sequencing implicates chromatin accessibility and genetic background in diabetic kidney disease progression by Wilson, Parker C., Muto, Yoshiharu, Wu, Haojia, Karihaloo, Anil, Waikar, Sushrut S., Humphreys, Benjamin D.

“…The proximal tubule is a key regulator of kidney function and glucose metabolism. Diabetic kidney disease leads to proximal tubule injury and changes in…”
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Underrecognized cause diarrhea in solid organ transplant: a report of astroviridae enteritis in liver transplant by Wilson, Parker, Rosenstengle, Craig, Spak, Cedric

“…We present a case of a 72-year-old liver transplant recipient 7 years prior who presents to our hospital with general malaise, fatigue, low-grade fevers, and…”
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Interstitial inflammation and interstitial fibrosis and tubular atrophy predict renal survival in lupus nephritis by Wilson, Parker C, Kashgarian, Michael, Moeckel, Gilbert

“…Abstract Background This study examines the effect of interstitial inflammation and interstitial fibrosis and tubular atrophy on renal survival in lupus…”
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Understanding How Genetic Background Affects Kidney Function at the Single-Cell Level by Wilson, Parker C., Humphreys, Benjamin D.

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60 Validation of a Novel High-Throughput Immunoassay for Measuring Symmetric Dimethylarginine as a Marker of Kidney Function by Wilson, Parker, El-khoury, Joe

“…Abstract Background Symmetric dimethylarginine (SDMA) is an emerging kidney function biomarker that has outperformed serum creatinine in several studies. SDMA…”
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Mapping genomic regulation of kidney disease and traits through high-resolution and interpretable eQTLs by Han, Seong Kyu, McNulty, Michelle T., Benway, Christopher J., Wen, Pei, Greenberg, Anya, Onuchic-Whitford, Ana C., Jang, Dongkeun, Flannick, Jason, Burtt, Noël P., Wilson, Parker C., Humphreys, Benjamin D., Wen, Xiaoquan, Han, Zhe, Lee, Dongwon, Sampson, Matthew G.

“…Expression quantitative trait locus (eQTL) studies illuminate genomic variants that regulate specific genes and contribute to fine-mapped loci discovered via…”
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Histologic grading of breast carcinoma: a multi-institution study of interobserver variation using virtual microscopy by Ginter, Paula S., Idress, Romana, D'Alfonso, Timothy M., Fineberg, Susan, Jaffer, Shabnam, Sattar, Abida K., Chagpar, Anees, Wilson, Parker, Harigopal, Malini

“…Breast carcinoma grading is an important prognostic feature recently incorporated into the AJCC Cancer Staging Manual. There is increased interest in applying…”
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Kidney tissue hypoxia dictates T cell-mediated injury in murine lupus nephritis by Chen, Ping-Min, Wilson, Parker C, Shyer, Justin A, Veselits, Margaret, Steach, Holly R, Cui, Can, Moeckel, Gilbert, Clark, Marcus R, Craft, Joe

“…The kidney is a frequent target of autoimmune injury, including in systemic lupus erythematosus; however, how immune cells adapt to kidney's unique environment…”
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Predicting proximal tubule failed repair drivers through regularized regression analysis of single cell multiomic sequencing by Ledru, Nicolas, Wilson, Parker C., Muto, Yoshiharu, Yoshimura, Yasuhiro, Wu, Haojia, Li, Dian, Asthana, Amish, Tullius, Stefan G., Waikar, Sushrut S., Orlando, Giuseppe, Humphreys, Benjamin D.

“…Renal proximal tubule epithelial cells have considerable intrinsic repair capacity following injury. However, a fraction of injured proximal tubule cells fails…”
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Mosaic loss of Y chromosome is associated with aging and epithelial injury in chronic kidney disease by Wilson, Parker C, Verma, Amit, Yoshimura, Yasuhiro, Muto, Yoshiharu, Li, Haikuo, Malvin, Nicole P, Dixon, Eryn E, Humphreys, Benjamin D

“…Mosaic loss of Y chromosome (LOY) is the most common chromosomal alteration in aging men. Here, we use single-cell RNA and ATAC sequencing to show that LOY is…”
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Kidney and organoid single-cell transcriptomics: the end of the beginning by Wilson, Parker C., Humphreys, Benjamin D.

“…Single-cell RNA sequencing (scRNA-seq) technologies are increasingly being applied to reveal cellular heterogeneity in kidney development and disease. In just…”
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Neuroblastoma suppressor of tumorigenicity 1 is a circulating protein associated with progression to end-stage kidney disease in diabetes by Kobayashi, Hiroki, Looker, Helen C, Satake, Eiichiro, D'Addio, Francesca, Wilson, Jonathan M, Saulnier, Pierre Jean, Md Dom, Zaipul I, O'Neil, Kristina, Ihara, Katsuhito, Krolewski, Bozena, Badger, Hannah S, Petrazzuolo, Adriana, Corradi, Domenico, Galecki, Andrzej, Wilson, Parker C, Najafian, Behzad, Mauer, Michael, Niewczas, Monika A, Doria, Alessandro, Humphreys, Benjamin D, Duffin, Kevin L, Fiorina, Paolo, Nelson, Robert G, Krolewski, Andrzej S

“…Circulating proteins associated with transforming growth factor-β (TGF-β) signaling are implicated in the development of diabetic kidney disease (DKD). It…”
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High frequency of p16 and SOX10 coexpression but not androgen receptor expression in triple-negative breast cancers by Yoon, Esther C., Wilson, Parker, Zuo, Tao, Pinto, Marguerite, Cole, Kimberly, Harigopal, Malini

“…Triple-negative breast cancers (TNBCs) represent approximately 12–17% of all breast cancers and have distinctively aggressive clinical courses. Because routine…”
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Defining cellular complexity in human autosomal dominant polycystic kidney disease by multimodal single cell analysis by Muto, Yoshiharu, Dixon, Eryn E., Yoshimura, Yasuhiro, Wu, Haojia, Omachi, Kohei, Ledru, Nicolas, Wilson, Parker C., King, Andrew J., Eric Olson, N., Gunawan, Marvin G., Kuo, Jay J., Cox, Jennifer H., Miner, Jeffrey H., Seliger, Stephen L., Woodward, Owen M., Welling, Paul A., Watnick, Terry J., Humphreys, Benjamin D.

“…Autosomal dominant polycystic kidney disease (ADPKD) is the leading genetic cause of end stage renal disease characterized by progressive expansion of kidney…”
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Androgen receptor expression is a favorable prognostic factor in triple-negative breast cancers by Zuo, Tao, Wilson, Parker, Cicek, Ali Fuat, Harigopal, Malini

“…Androgen receptor (AR) expression is an emerging prognostic marker that has been observed in 25% to 75% of triple-negative breast cancers (TNBCs) that lack…”
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Epigenomics and the kidney by Wilson, Parker C., Ledru, Nicolas, Humphreys, Benjamin D.

“…PURPOSE OF REVIEWEpigenetic modifications are reversible changes to a cellʼs DNA or histones that alter gene expression but not DNA sequence. The present…”
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