Search Results - "Parker, Zachary M."

ISG15-dependent activation of the sensor MDA5 is antagonized by the SARS-CoV-2 papain-like protease to evade host innate immunity by Liu, GuanQun, Lee, Jung-Hyun, Parker, Zachary M., Acharya, Dhiraj, Chiang, Jessica J., van Gent, Michiel, Riedl, William, Davis-Gardner, Meredith E., Wies, Effi, Chiang, Cindy, Gack, Michaela U.

“…Activation of the RIG-I-like receptors, retinoic-acid inducible gene I (RIG-I) and melanoma differentiation-associated protein 5 (MDA5), establishes an…”
Get full text

Immune- and Nonimmune-Compartment-Specific Interferon Responses Are Critical Determinants of Herpes Simplex Virus-Induced Generalized Infections and Acute Liver Failure by Parker, Zachary M, Pasieka, Tracy Jo, Parker, George A, Leib, David A

“…The interferon (IFN) response to viral pathogens is critical for host survival. In humans and mouse models, defects in IFN responses can result in lethal…”
Get full text

Bioluminescent imaging reveals divergent viral pathogenesis in two strains of Stat1-deficient mice, and in αßγ interferon receptor-deficient mice by Pasieka, Tracy Jo, Collins, Lynne, O'Connor, Megan A, Chen, Yufei, Parker, Zachary M, Berwin, Brent L, Piwnica-Worms, David R, Leib, David A

“…Pivotal components of the IFN response to virus infection include the IFN receptors (IFNR), and the downstream factor signal transducer and activator of…”
Get full text

Role of the DNA Sensor STING in Protection from Lethal Infection following Corneal and Intracerebral Challenge with Herpes Simplex Virus 1 by Parker, Zachary M, Murphy, Aisling A, Leib, David A

“…STING is a protein in the cytosolic DNA and cyclic dinucleotide sensor pathway that is critical for the initiation of innate responses to infection by various…”
Get full text

TRIM23 mediates virus-induced autophagy via activation of TBK1 by Sparrer, Konstantin M. J., Gableske, Sebastian, Zurenski, Matthew A., Parker, Zachary M., Full, Florian, Baumgart, Gavin J., Kato, Jiro, Pacheco-Rodriguez, Gustavo, Liang, Chengyu, Pornillos, Owen, Moss, Joel, Vaughan, Martha, Gack, Michaela U.

“…Autophagy and interferon (IFN)-mediated innate immunity are critical antiviral defence mechanisms, and recent evidence indicated that tripartite motif (TRIM)…”
Get full text

Synergistic control of herpes simplex virus pathogenesis by IRF-3, and IRF-7 revealed through non-invasive bioluminescence imaging by Murphy, Aisling A, Rosato, Pamela C, Parker, Zachary M, Khalenkov, Alexey, Leib, David A

“…Abstract Interferon regulatory factors IRF-3 and IRF-7 are central to the establishment of the innate antiviral response. This study examines HSV-1…”
Get full text

The differential interferon responses of two strains of Stat1-deficient mice do not alter susceptibility to HSV-1 and VSV in vivo by Katzenell, Sarah, Chen, Yufei, Parker, Zachary M, Leib, David A

“…Abstract Stat1 is a pivotal transcription factor for generation of the interferon (IFN)-dependent antiviral response. Two Stat1 knockout mouse lines have been…”
Get full text

Spermidine regulates Vibrio cholerae biofilm formation via transport and signaling pathways by McGinnis, Marcus W, Parker, Zachary M, Walter, Nicholas E, Rutkovsky, Alex C, Cartaya-Marin, Claudia, Karatan, Ece

“…Vibrio cholerae, the causative agent of the devastating diarrheal disease cholera, can form biofilms on diverse biotic and abiotic surfaces. Biofilm formation…”
Get full text

Elevated levels of the norspermidine synthesis enzyme NspC enhance Vibrio cholerae biofilm formation without affecting intracellular norspermidine concentrations by Parker, Zachary M., Pendergraft, Samuel S., Sobieraj, Jim, McGinnis, Marcus M., Karatan, Ece

“…Abstract Biofilm formation in Vibrio cholerae is in part regulated by norspermidine, a polyamine synthesized by the enzyme carboxynorspermidine decarboxylase…”
Get full text

Bioluminescent Imaging Reveals Divergent Viral Pathogenesis in Two Strains of Stat1-Deficient Mice, and in [alpha]ß[gamma] Interferon Receptor-Deficient Mice by Pasieka, Tracy Jo, Collins, Lynne, O'Connor, Megan A, Chen, Yufei, Parker, Zachary M, Berwin, Brent L, Piwnica-Worms, David R, Leib, David A

“…Pivotal components of the IFN response to virus infection include the IFN receptors (IFNR), and the downstream factor signal transducer and activator of…”
Get full text

Bioluminescent Imaging Reveals Divergent Viral Pathogenesis in Two Strains of Stat1-Deficient Mice, and in alpha s gamma Interferon Receptor-Deficient Mice by Pasieka, Tracy Jo, Collins, Lynne, O'Connor, Megan A, Chen, Yufei, Parker, Zachary M, Berwin, Brent L, Piwnica-Worms, David R, Leib, David A

“…Pivotal components of the IFN response to virus infection include the IFN receptors (IFNR), and the downstream factor signal transducer and activator of…”
Get full text