Search Results - "Parker, William L."

Preparation of (R)-Amines from Racemic Amines with an (S)-Amine Transaminase from Bacillus megaterium by Hanson, Ronald L., Davis, Brian L., Chen, Yijun, Goldberg, Steven L., Parker, William L., Tully, Thomas P., Montana, Michael A., Patel, Ramesh N.

“…Screening was carried out to identify strains useful for the preparation of (R)‐1‐cyclopropylethylamine and (R)‐sec‐butylamine by resolution of the racemic…”
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Preparation of an Amino Acid Intermediate for the Dipeptidyl Peptidase IV Inhibitor, Saxagliptin, using a Modified Phenylalanine Dehydrogenase by Hanson, Ronald L., Goldberg, Steven L., Brzozowski, David B., Tully, Thomas P., Cazzulino, Dana, Parker, William L., Lyngberg, Olav K., Vu, Truc C., Wong, Michael K., Patel, Ramesh N.

“…The non‐proteinogenic amino acid 2‐(3‐hydroxy‐1‐adamantyl)‐(2S)‐aminoethanoic acid [2, (S)‐3‐hydroxyadamantylglycine], is a key intermediate required for the…”
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Influence of Formaldehyde Impurity in Polysorbate 80 and PEG-300 on the Stability of a Parenteral Formulation of BMS-204352: Identification and Control of the Degradation Product by Nassar, Munir N., Nesarikar, Vishwas N., Lozano, Ruben, Parker, William L., Huang, Yande, Palaniswamy, Venkatapuram, Xu, Weiwei, Khaselev, Nona

“…The purpose of this study was to identify a degradation product formed in the clinical parenteral formulation of BMS-204352, investigate the role of excipients…”
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Enzymatic Preparation of an R‑Amino Acid Intermediate for a γ‑Secretase Inhibitor by Hanson, Ronald L, Johnston, Robert M, Goldberg, Steven L, Parker, William L, Goswami, Animesh

“…(R)-5,5,5-Trifluoronorvaline, an intermediate for a γ-secretase inhibitor (BMS-708163) under development, was initially prepared from the corresponding keto…”
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Preparation of (S)-1-Cyclopropyl-2-methoxyethanamine by a Chemoenzymatic Route Using Leucine Dehydrogenase by Parker, William L, Hanson, Ronald L, Goldberg, Steven L, Tully, Thomas P, Goswami, Animesh

“…(S)-1-Cyclopropyl-2-methoxyethanamine is a key chiral intermediate for the synthesis of a corticotropin-releasing factor-1(CRF-1) receptor antagonist…”
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Enzymatic Preparation of an (S)-Amino Acid from a Racemic Amino Acid by Chen, Yijun, Goldberg, Steven L, Hanson, Ronald L, Parker, William L, Gill, Iqbal, Tully, Thomas P, Montana, Michael A, Goswami, Animesh, Patel, Ramesh N

“…The (S)-amino acid, (S)-2-amino-3-(6-o-tolylpyridin-3-yl)propanoic acid (3), is a key intermediate needed for synthesis of an antidiabetic drug candidate…”
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Selection of an Enantioselective Process for the Preparation of a CGRP Receptor Inhibitor by Cann, Reginald O, Chen, Chung-Pin H, Gao, Qi, Hanson, Ronald L, Hsieh, Daniel, Li, Jun, Lin, Dong, Parsons, Rodney L, Pendri, Yadagiri, Nielsen, R. Brent, Nugent, William A, Parker, William L, Quinlan, Sandra, Reising, Nathan P, Remy, Brenda, Sausker, Justin, Wang, Xuebao

“…(R)-N-(3-(7-Methyl-1H-indazol-5-yl)-1-(4-(1-methylpiperidin-4-yl)piperazine-1-yl)-1-oxopropan-2-yl)-4-(2-oxo-1,2-dihydroquinolin-3-yl)piperidine-1-carboxamide…”
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Enzymatic Preparation of a d-Amino Acid from a Racemic Amino Acid or Keto Acid by Hanson, Ronald L, Davis, Brian L, Goldberg, Steven L, Johnston, Robert M, Parker, William L, Tully, Thomas P, Montana, Michael A, Patel, Ramesh N

“…The d-amino acid (R)-2-amino-3-(7-methyl-1 H-indazol-5-yl)propanoic acid (3) is a key intermediate needed for synthesis of a drug candidate compound. Enzymatic…”
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Enzymatic C-4 deacetylation of 10-deacetylbaccatin III by Hanson, Ronald L., Parker, William L., Patel, Ramesh N.

“…Second‐generation paclitaxel analogues that require replacement of the C‐4 acetate by other substituents are in development. An enzyme able to specifically…”
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Microbial N-demethylation: biotransformation and recovery of a drug metabolite by Davis, Brian L., Liu, Mark S., Hanson, Ronald L., Parker, William L., Patel, Ramesh N.

“…A total of 39 microbes were screened for the ability to selectively N‐demethylate…”
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Clerocidin, a terpenoid antibiotic, inhibits bacterial DNA gyrase by McCullough, J E, Muller, M T, Howells, A J, Maxwell, A, O'Sullivan, J, Summerill, R S, Parker, W L, Wells, J S, Bonner, D P, Fernandes, P B

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Structure of ionomycin - a novel diacidic polyether antibiotic having high affinity for calcium ions by Toeplitz, Barbara K, Cohen, Allen I, Funke, Phillip T, Parker, William L, Gougoutas, Jack Z

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The strcture determination of antibiotic compounds from Hypericum uliginosum. I by Parker, William L, Johnson, Francis

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A nomenclature proposal for the octapeptin antibiotics by Meyers, E, Parker, W L, Brown, W E

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Hypothalamic Na+,K(+)-ATPase inhibitor constricts pulmonary arteries of spontaneously hypertensive rats by Janssens, S P, Kachoris, C, Parker, W L, Hales, C A, Haupert, Jr, G T

“…Hypothalamic inhibitory factor (HIF) is an endogenous high-affinity inhibitor of Na+,K(+)-ATPase with ouabain-like properties and has been implicated in the…”
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SQ 27,860, a simple carbapenem produced by species of Serratia and Erwinia by Parker, W L, Rathnum, M L, Wells, Jr, J S, Trejo, W H, Principe, P A, Sykes, R B

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Cepacin A and cepacin B, two new antibiotics produced by Pseudomonas cepacia by Parker, W L, Rathnum, M L, Seiner, V, Trejo, W H, Principe, P A, Sykes, R B

“…Two new acetylenic antibiotics, cepacins A and B, have been isolated from the fermentation broth of Pseudomonas cepacia SC 11,783 and assigned structures 1 and…”
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EM5400, a family of monobactam antibiotics produced by Agrobacterium radiobacter. II. Isolation and structure determination by Parker, W L, Rathnum, M L

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Aerocyanidin, a new antibiotic produced by Chromobacterium violaceum by Parker, W L, Rathnum, M L, Johnson, J H, Wells, J S, Principe, P A, Sykes, R B

“…Aerocyanidin, a new antibiotic containing an isonitrile group, has been isolated from fermentations of Chromobacterium violaceum ATCC 53434. Structure 1 was…”
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Xylocandin: a new complex of antifungal peptides. II. Structural studies and chemical modifications by Bisacchi, G S, Hockstein, D R, Koster, W H, Parker, W L, Rathnum, M L, Unger, S E

“…Xylocandins A1, A2, B1, B2, C1, C2, D1 and D2 are new antifungal peptides isolated from Pseudomonas cepacia ATCC 39277. The molecular weights of the…”
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