Search Results - "Parker, Richard A"

The unblinding of statisticians in clinical trials: commentary on Iflaifel et al., Trials 2023 by Parker, Richard A

“…Abstract Recently, the Blinding of Trial Statisticians research team, Iflaifel and colleagues, have produced detailed guidance regarding the blinding or…”
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Using multiple agreement methods for continuous repeated measures data: a tutorial for practitioners by Parker, Richard A, Scott, Charles, Inácio, Vanda, Stevens, Nathaniel T

“…Studies of agreement examine the distance between readings made by different devices or observers measuring the same quantity. If the values generated by each…”
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Multiple secondary outcome analyses: precise interpretation is important by Parker, Richard A, Weir, Christopher J

“…Analysis of multiple secondary outcomes in a clinical trial leads to an increased probability of at least one false significant result among all secondary…”
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Relationship of self-rated health with fatal and non-fatal outcomes in cardiovascular disease: a systematic review and meta-analysis by Mavaddat, Nahal, Parker, Richard A, Sanderson, Simon, Mant, Jonathan, Kinmonth, Ann Louise

“…People who rate their health as poor experience higher all-cause mortality. Study of disease-specific association with self-rated health might increase…”
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Response to Letter from Wong on determining the target difference in sample size calculations for randomised controlled trials by Cook, Jonathan A, Parker, Richard A

“…The target difference refers to the treatment effect specified in the sample size calculation conducted when designing the study to detect a difference between…”
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The importance of clinical importance when determining the target difference in sample size calculations by Parker, Richard A, Cook, Jonathan A

“…Recently, it was argued that clinically important differences should play no role in sample size calculations. Instead, it was proposed that sample size…”
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A mixed method evaluation of a theory based intervention to reduce sedentary behaviour in contact centres- the stand up for health stepped wedge feasibility study by Sivaramakrishnan, Divya, Baker, Graham, Parker, Richard A, Manner, Jillian, Lloyd, Scott, Jepson, Ruth

“…Contact centres have higher levels of sedentary behaviour than other office-based workplaces. Stand Up for Health (SUH) is a theory-based intervention…”
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Divergent confidence intervals among pre-specified analyses in the HiSTORIC stepped wedge trial: An exploratory post-hoc investigation by Parker, Richard A, Keerie, Catriona, Weir, Christopher J, Anand, Atul, Mills, Nicholas L

“…The high-sensitivity cardiac troponin on presentation to rule out myocardial infarction (HiSTORIC) study was a stepped-wedge cluster randomised trial with long…”
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Use of drains versus no drains after burr-hole evacuation of chronic subdural haematoma: a randomised controlled trial by Santarius, Thomas, MRCS, Kirkpatrick, Peter J, FMedSci, Ganesan, Dharmendra, FRCS[SN], Chia, Hui Ling, MMed, Jalloh, Ibrahim, MRCS, Smielewski, Peter, PhD, Richards, Hugh K, PhD, Marcus, Hani, MRCS, Parker, Richard A, MSc, Price, Stephen J, FRCS[SN], Kirollos, Ramez W, FRCS[SN], Pickard, John D, Prof, Hutchinson, Peter J, FRCS[SN]

“…Summary Background Chronic subdural haematoma causes serious morbidity and mortality. It recurs after surgical evacuation in 5–30% of patients. Drains might…”
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Application of Mixed Effects Limits of Agreement in the Presence of Multiple Sources of Variability: Exemplar from the Comparison of Several Devices to Measure Respiratory Rate in COPD Patients by Parker, Richard A, Weir, Christopher J, Rubio, Noah, Rabinovich, Roberto, Pinnock, Hilary, Hanley, Janet, McCloughan, Lucy, Drost, Ellen M, Mantoani, Leandro C, MacNee, William, McKinstry, Brian

“…The Bland-Altman limits of agreement method is widely used to assess how well the measurements produced by two raters, devices or systems agree with each…”
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Supported Telemonitoring and Glycemic Control in People with Type 2 Diabetes: The Telescot Diabetes Pragmatic Multicenter Randomized Controlled Trial by Wild, Sarah H, Hanley, Janet, Lewis, Stephanie C, McKnight, John A, McCloughan, Lucy B, Padfield, Paul L, Parker, Richard A, Paterson, Mary, Pinnock, Hilary, Sheikh, Aziz, McKinstry, Brian

“…Self-monitoring of blood glucose among people with type 2 diabetes not treated with insulin does not appear to be effective in improving glycemic control. We…”
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Impact of community based peer support in type 2 diabetes: a cluster randomised controlled trial of individual and/or group approaches by Simmons, David, Prevost, A Toby, Bunn, Chris, Holman, Daniel, Parker, Richard A, Cohn, Simon, Donald, Sarah, Paddison, Charlotte A M, Ward, Candice, Robins, Peter, Graffy, Jonathan

“…Diabetes peer support, where one person with diabetes helps guide and support others, has been proposed as a way to improve diabetes management. We have tested…”
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Rifaximin vs. lactulose in treatment of minimal hepatic encephalopathy by Sidhu, Sandeep S., Goyal, Omesh, Parker, Richard A., Kishore, Harsh, Sood, Ajit

“…Background & Aims Lactulose and rifaximin have already been shown to improve both cognitive functions and health related quality of life (HRQOL) in MHE…”
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Direct Comparison of Virtual-Histology Intravascular Ultrasound and Optical Coherence Tomography Imaging for Identification of Thin-Cap Fibroatheroma by Brown, Adam J, Obaid, Daniel R, Costopoulos, Charis, Parker, Richard A, Calvert, Patrick A, Teng, Zhongzhao, Hoole, Stephen P, West, Nick E J, Goddard, Martin, Bennett, Martin R

“…Although rupture of thin-cap fibroatheroma (TCFA) underlies most myocardial infarctions, reliable TCFA identification remains challenging. Virtual-histology…”
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Stability of empathy among undergraduate medical students: a longitudinal study at one UK medical school by Quince, Thelma A, Parker, Richard A, Wood, Diana F, Benson, John A

“…Empathy is important to patient care. The prevailing view is that empathy declines during university medical education. The significance of that decline has…”
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Increasing Our Understanding of Reactivity to Pedometers in Adults by CLEMES, Stacy A, PARKER, Richard A. A

“…To investigate the presence of reactivity, if any, to wearing sealed and unsealed pedometers, with and without step count recording. On the first visit to the…”
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Statistical analysis plan for the motor neuron disease systematic multi-arm adaptive randomised trial (MND-SMART) by Parker, Richard A, Weir, Christopher J, Pham, Tra My, White, Ian R, Stallard, Nigel, Parmar, Mahesh K B, Swingler, Robert J, Dakin, Rachel S, Pal, Suvankar, Chandran, Siddharthan

“…MND-SMART is a platform, multi-arm, multi-stage, multi-centre, randomised controlled trial recruiting people with motor neuron disease. Initially, the…”
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Examining the effectiveness of telemonitoring with routinely acquired blood pressure data in primary care: challenges in the statistical analysis by Parker, Richard A, Padfield, Paul, Hanley, Janet, Pinnock, Hilary, Kennedy, John, Stoddart, Andrew, Hammersley, Vicky, Sheikh, Aziz, McKinstry, Brian

“…Scale-up BP was a quasi-experimental implementation study, following a successful randomised controlled trial of the roll-out of telemonitoring in primary care…”
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Repeat prostate biopsy strategies after initial negative biopsy: meta-regression comparing cancer detection of transperineal, transrectal saturation and MRI guided biopsy by Nelson, Adam W, Harvey, Rebecca C, Parker, Richard A, Kastner, Christof, Doble, Andrew, Gnanapragasam, Vincent J

“…There is no consensus on how to investigate men with negative transrectal ultrasound guided prostate biopsy (TRUS-B) but ongoing suspicion of cancer. Three…”
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The importance of the feasibility study: Lessons from a study of the hand-held fan used to relieve dyspnea in people who are breathless at rest by Booth, Sara, Galbraith, Sarah, Ryan, Richella, Parker, Richard A, Johnson, Miriam

“…Background: The dyspnea accompanying advanced cardiorespiratory disease is often refractory to palliation. It is disabling, distressing and associated with the…”
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