Search Results - "Parker, Matthew W."

Mechanisms and regulation of DNA replication initiation in eukaryotes by Parker, Matthew W, Botchan, Michael R, Berger, James M

“…Cellular DNA replication is initiated through the action of multiprotein complexes that recognize replication start sites in the chromosome (termed origins)…”
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Fibrotic extracellular matrix activates a profibrotic positive feedback loop by Parker, Matthew W, Rossi, Daniel, Peterson, Mark, Smith, Karen, Sikström, Kristina, White, Eric S, Connett, John E, Henke, Craig A, Larsson, Ola, Bitterman, Peter B

“…Pathological remodeling of the extracellular matrix (ECM) by fibroblasts leads to organ failure. Development of idiopathic pulmonary fibrosis (IPF) is…”
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A new class of disordered elements controls DNA replication through initiator self-assembly by Parker, Matthew W, Bell, Maren, Mir, Mustafa, Kao, Jonchee A, Darzacq, Xavier, Botchan, Michael R, Berger, James M

“…The initiation of DNA replication in metazoans occurs at thousands of chromosomal sites known as origins. At each origin, the Origin Recognition Complex (ORC),…”
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Structural Basis for Selective Vascular Endothelial Growth Factor-A (VEGF-A) Binding to Neuropilin-1 by Parker, Matthew W., Xu, Ping, Li, Xiaobo, Vander Kooi, Craig W.

“…Neuropilin-1 (Nrp1) is an essential receptor for angiogenesis that binds to VEGF-A. Nrp1 binds directly to VEGF-A with high affinity, but the nature of their…”
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DNA-Stimulated Liquid-Liquid phase separation by eukaryotic topoisomerase ii modulates catalytic function by Jeong, Joshua, Lee, Joyce H, Carcamo, Claudia C, Parker, Matthew W, Berger, James M

“…Type II topoisomerases modulate chromosome supercoiling, condensation, and catenation by moving one double-stranded DNA segment through a transient break in a…”
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Molecular determinants of phase separation for Drosophila DNA replication licensing factors by Parker, Matthew W, Kao, Jonchee A, Huang, Alvin, Berger, James M, Botchan, Michael R

“…Liquid-liquid phase separation (LLPS) of intrinsically disordered regions (IDRs) in proteins can drive the formation of membraneless compartments in cells…”
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Structural Basis for VEGF-C Binding to Neuropilin-2 and Sequestration by a Soluble Splice Form by Parker, Matthew W., Linkugel, Andrew D., Goel, Hira Lal, Wu, Tingting, Mercurio, Arthur M., Vander Kooi, Craig W.

“…Vascular endothelial growth factor C (VEGF-C) is a potent lymphangiogenic cytokine that signals via the coordinated action of two cell surface receptors,…”
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Function of Members of the Neuropilin Family as Essential Pleiotropic Cell Surface Receptors by Parker, Matthew W, Guo, Hou-Fu, Li, Xiaobo, Linkugel, Andrew D, Vander Kooi, Craig W

“…The neuropilin (Nrp) family consists of essential multifunctional vertebrate cell surface receptors. Nrps were initially characterized as receptors for class…”
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Mechanism of selective VEGF-A binding by neuropilin-1 reveals a basis for specific ligand inhibition by Parker, Matthew W, Xu, Ping, Guo, Hou-Fu, Vander Kooi, Craig W

“…Neuropilin (Nrp) receptors function as essential cell surface receptors for the Vascular Endothelial Growth Factor (VEGF) family of proangiogenic cytokines and…”
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Stress-only SPECT myocardial perfusion imaging: A review by Gowd, B.M. Pampana, Heller, Gary V., Parker, Matthew. W.

“…Myocardial perfusion imaging (MPI) has enjoyed considerable success for decades due to its diagnostic accuracy and wealth of prognostic data. Despite this…”
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Effect of C-Terminal Sequence on Competitive Semaphorin Binding to Neuropilin-1 by Parker, Matthew W., Linkugel, Andrew D., Vander Kooi, Craig W.

“…Neuropilins (Nrp) are type I transmembrane proteins that function as receptors for vascular endothelial growth factor (VEGF) and class III Semaphorin (Sema3)…”
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Structural Mechanism of Laforin Function in Glycogen Dephosphorylation and Lafora Disease by Raththagala, Madushi, Brewer, M. Kathryn, Parker, Matthew W., Sherwood, Amanda R., Wong, Brian K., Hsu, Simon, Bridges, Travis M., Paasch, Bradley C., Hellman, Lance M., Husodo, Satrio, Meekins, David A., Taylor, Adam O., Turner, Benjamin D., Auger, Kyle D., Dukhande, Vikas V., Chakravarthy, Srinivas, Sanz, Pascual, Woods, Virgil L., Li, Sheng, Vander Kooi, Craig W., Gentry, Matthew S.

“…Glycogen is the major mammalian glucose storage cache and is critical for energy homeostasis. Glycogen synthesis in neurons must be tightly controlled due to…”
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Furin Processing of Semaphorin 3F Determines Its Anti-Angiogenic Activity by Regulating Direct Binding and Competition for Neuropilin by Parker, Matthew W, Hellman, Lance M, Xu, Ping, Fried, Michael G, Vander Kooi, Craig W

“…Neuropilin is an essential cell surface receptor that functions in both semaphorin-dependent axon guidance and vascular endothelial growth factor…”
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Stress-first Myocardial Perfusion Imaging by Hussain, Nasir, MD, Parker, Matthew W., MD, Henzlova, Milena J., MD, Duvall, William Lane, MD

“…Stress-first approaches to myocardial perfusion imaging provide diagnostically and prognostically accurate perfusion data equivalent to a full rest-stress…”
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Cost-Effectiveness of Ranolazine Added to Standard-of-Care Treatment in Patients With Chronic Stable Angina Pectoris by Kohn, Christine G., PharmD, Parker, Matthew W., MD, Limone, Brendan L., PharmD, Coleman, Craig I., PharmD

“…Ranolazine has been shown to decrease angina pectoris frequency and nitroglycerin consumption. We assessed the cost-effectiveness of ranolazine when added to…”
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Prognostic Accuracy of Clinical Prediction Rules for Early Post-Pulmonary Embolism All-Cause Mortality by Kohn, Christine G., PharmD, Mearns, Elizabeth S., PharmD, Parker, Matthew W., MD, Hernandez, Adrian V., MD, PhD, Coleman, Craig I., PharmD

“…Abstract BACKGROUND: Studies suggest outpatient treatment or early discharge of patients with acute pulmonary embolism (aPE) is reasonable for those deemed to…”
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Protein intrinsically disordered regions have a non-random, modular architecture by McConnell, Brendan S, Parker, Matthew W

“…Protein sequences can be broadly categorized into two classes: those which adopt stable secondary structure and fold into a domain (i.e. globular proteins),…”
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The Promise and Pitfalls of Three-Dimensional Vena Contracta for Mitral Regurgitation by Brissett, Shantel, Aurigemma, Gerard P., Parker, Matthew W.

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The origin recognition complex requires chromatin tethering by a hypervariable intrinsically disordered region that is functionally conserved from sponge to man by Adiji, Olubu A, McConnell, Brendan S, Parker, Matthew W

“…The first step toward eukaryotic genome duplication is loading of the replicative helicase onto chromatin. This 'licensing' step initiates with the recruitment…”
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Predictors of an Inadequate Defibrillation Safety Margin at ICD Implantation by Hsu, Jonathan C., MD, MAS, Marcus, Gregory M., MD, MAS, Al-Khatib, Sana M., MD, MHS, Wang, Yongfei, MS, Curtis, Jeptha P., MD, Sood, Nitesh, MD, Parker, Matthew W., MD, Kluger, Jeffrey, MD, Lampert, Rachel, MD, Russo, Andrea M., MD

“…Abstract Background Defibrillation testing is often performed to establish effective arrhythmia termination, but predictors and consequences of an inadequate…”
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