Solid-phase synthesis of functionalized 1,2,3-triazoles

Solid-phase synthesis of functionalized 1,2,3-triazoles

Functionalized 1,2,3-triazoles are prepared by 2+3 cycloaddition of resin bound α-azido esters with substituted alkynes. The reaction is regioselective when the electron-deficient alkyne methyl propiolate is used. Functionalized 1,2,3-triazoles are prepared by 2+3 cycloaddition of resin bound α-azid...

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Bibliographic Details
Published in:Tetrahedron letters Vol. 43; no. 22; pp. 4059 - 4061
Main Authors: Blass, Benjamin E, Coburn, Keith R, Faulkner, Amy L, Hunn, Cheryl L, Natchus, Michael G, Parker, M.Sharon, Portlock, David E, Tullis, Joshua S, Wood, Richard
Format: Journal Article
Language:English
Published: Elsevier Ltd 27-05-2002
Online Access:Get full text
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Summary:Functionalized 1,2,3-triazoles are prepared by 2+3 cycloaddition of resin bound α-azido esters with substituted alkynes. The reaction is regioselective when the electron-deficient alkyne methyl propiolate is used. Functionalized 1,2,3-triazoles are prepared by 2+3 cycloaddition of resin bound α-azido esters with substituted alkynes. The reaction is regioselective when the electron-deficient alkyne methyl propiolate is used.
ISSN:0040-4039
1873-3581
DOI:10.1016/S0040-4039(02)00742-6