Search Results - "Parker, Lisa C"

Role of unfolded proteins in lung disease by Bradley, Kirsty L, Stokes, Clare A, Marciniak, Stefan J, Parker, Lisa C, Condliffe, Alison M

“…The lungs are exposed to a range of environmental toxins (including cigarette smoke, air pollution, asbestos) and pathogens (bacterial, viral and fungal), and…”
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Airway Epithelial Cells Generate Pro-inflammatory Tenascin-C and Small Extracellular Vesicles in Response to TLR3 Stimuli and Rhinovirus Infection by Mills, Jake T, Schwenzer, Anja, Marsh, Elizabeth K, Edwards, Michael R, Sabroe, Ian, Midwood, Kim S, Parker, Lisa C

“…Viral infections are a common cause of asthma exacerbations, with human rhinoviruses (RV) the most common trigger. RV signals through a number of different…”
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Emerging Regulatory Roles of Dual-Specificity Phosphatases in Inflammatory Airway Disease by Manley, Grace C A, Parker, Lisa C, Zhang, Yongliang

“…Inflammatory airway disease, such as asthma and chronic obstructive pulmonary disease (COPD), is a major health burden worldwide. These diseases cause large…”
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The role of interleukin-1 and interleukin-18 in pro-inflammatory and anti-viral responses to rhinovirus in primary bronchial epithelial cells by Piper, Siân C, Ferguson, John, Kay, Linda, Parker, Lisa C, Sabroe, Ian, Sleeman, Matthew A, Briend, Emmanuel, Finch, Donna K

“…Human Rhinovirus (HRV) is associated with acute exacerbations of chronic respiratory disease. In healthy individuals, innate viral recognition pathways trigger…”
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The expression and roles of Toll-like receptors in the biology of the human neutrophil by Parker, Lisa C., Whyte, Moira K. B., Dower, Steven K., Sabroe, Ian

“…Neutrophils are amongst the first immune cells to arrive at sites of infection, where they initiate antimicrobial and proinflammatory functions, which serve to…”
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Diesel exhaust particle exposure in vitro alters monocyte differentiation and function by Chaudhuri, Nazia, Jary, Hannah, Lea, Simon, Khan, Naimat, Piddock, Katie C, Dockrell, David H, Donaldson, Ken, Duffin, Rodger, Singh, Dave, Parker, Lisa C, Sabroe, Ian

“…Air pollution by diesel exhaust particles is associated with elevated mortality and increased hospital admissions in individuals with respiratory diseases such…”
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Pellino-1 Regulates the Responses of the Airway to Viral Infection by Marsh, Elizabeth K, Prestwich, Elizabeth C, Williams, Lynne, Hart, Amber R, Muir, Clare F, Parker, Lisa C, Jonker, Marnix R, Heijink, Irene H, Timens, Wim, Fife, Mark, Hussell, Tracy, Hershenson, Marc B, Bentley, J Kelley, Sun, Shao-Cong, Barksby, Ben S, Borthwick, Lee A, Stewart, James P, Sabroe, Ian, Dockrell, David H, Marriott, Helen M

“…Exposure to respiratory pathogens is a leading cause of exacerbations of airway diseases such as asthma and chronic obstructive pulmonary disease (COPD)…”
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Role of Interleukin-1 and MyD88-Dependent Signaling in Rhinovirus Infection by STOKES, Clare A, ISMAIL, Saila, DICK, Emily P, BENNETT, Julie A, JOHNSTON, Sebastian L, EDWARDS, Michael R, SABROE, Ian, PARKER, Lisa C

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Pellino-1 Selectively Regulates Epithelial Cell Responses to Rhinovirus by BENNETT, Julie A, PRINCE, Lynne R, PARKER, Lisa C, STOKES, Clare A, DE BRUIN, Harold G, DEN BERGE, Maarten Van, HEIJINK, Irene H, WHYTE, Moira K, SABROE, Ian

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Phosphoinositide-3 kinase inhibition modulates responses to rhinovirus by mechanisms that are predominantly independent of autophagy by Ismail, Saila, Stokes, Clare A, Prestwich, Elizabeth C, Roberts, Rebecca L, Juss, Jatinder K, Sabroe, Ian, Parker, Lisa C

“…Human rhinoviruses (HRV) are a major cause of exacerbations of airways disease. Aspects of cell signalling responses to HRV infection remain unclear,…”
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Roles of neutrophils in the regulation of the extent of human inflammation through delivery of IL-1 and clearance of chemokines by Basran, Alexander, Jabeen, Maisha, Bingle, Lynne, Stokes, Clare A., Dockrell, David H., Whyte, Moira K. B., Walmsley, Sarah R., Higgins, Kathryn R., Vogel, Stefanie N., Wilson, Heather L., Prince, Lynne R., Prestwich, Elizabeth C., Sabroe, Ruth A., Parker, Lisa C., Sabroe, Ian

“…Endotoxin‐induced neutrophil recruitment in humans and its potential regulation by CXCL8 clearance. This study examined the establishment of neutrophilic…”
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Cooperative molecular and cellular networks regulate Toll-like receptor-dependent inflammatory responses by Morris, Gavin E, Parker, Lisa C, Ward, Jon R, Jones, Elizabeth C, Whyte, Moira K.B, Brightling, Christopher E, Bradding, Peter, Dower, Steven K, Sabroe, Ian

“…Viral and bacterial pathogens cause inflammation via Toll-like receptor (TLR) signaling. We have shown that effective responses to LPS may depend on…”
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The role of TLRs in neutrophil activation by Prince, Lynne R, Whyte, Moira K, Sabroe, Ian, Parker, Lisa C

“…Highlights ► Neutrophil TLR expression is modulated by pathogens and during disease. ► Neutrophils are activated in response to DAMPs in a TLR-dependent…”
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Toll-Like Receptor (TLR)2 and TLR4 Agonists Regulate CCR Expression in Human Monocytic Cells by Parker, Lisa C, Whyte, Moira K. B, Vogel, Stefanie N, Dower, Steven K, Sabroe, Ian

“…Interactions between proinflammatory and cell maturation signals, and the pathways that regulate leukocyte migration, are of fundamental importance in…”
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DUSP10 Negatively Regulates the Inflammatory Response to Rhinovirus through Interleukin-1β Signaling by Manley, Grace C A, Stokes, Clare A, Marsh, Elizabeth K, Sabroe, Ian, Parker, Lisa C

“…Rhinoviral infection is a common trigger of the excessive inflammation observed during exacerbations of asthma and chronic obstructive pulmonary disease…”
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Endotoxin tolerance induces selective alterations in neutrophil function by Parker, Lisa C., Jones, Elizabeth C., Prince, Lynne R., Dower, Steven K., Whyte, Moira K. B., Sabroe, Ian

“…Endotoxin tolerance has the potential to limit phagocyte responses to Toll‐like receptor (TLR) agonists, but the role of tolerance in regulating neutrophil…”
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Temporal Interleukin-1β Secretion from Primary Human Peripheral Blood Monocytes by P2X7-independent and P2X7-dependent Mechanisms by Ward, Jon R., West, Peter W., Ariaans, Mark P., Parker, Lisa C., Francis, Sheila E., Crossman, David C., Sabroe, Ian, Wilson, Heather L.

“…The processing and regulated secretion of IL-1β are critical points of control of the biological activity of this important pro-inflammatory cytokine. IL-1β is…”
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Prolyl hydroxylase 3 (PHD3) is essential for hypoxic regulation of neutrophilic inflammation in humans and mice by Walmsley, Sarah R, Chilvers, Edwin R, Thompson, Alfred A, Vaughan, Kathryn, Marriott, Helen M, Parker, Lisa C, Shaw, Gary, Parmar, Selina, Schneider, Martin, Sabroe, Ian, Dockrell, David H, Milo, Marta, Taylor, Cormac T, Johnson, Randall S, Pugh, Christopher W, Ratcliffe, Peter J, Maxwell, Patrick H, Carmeliet, Peter, Whyte, Moira K B

“…The regulation of neutrophil lifespan by induction of apoptosis is critical for maintaining an effective host response and preventing excessive inflammation…”
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Expression of interleukin‐1 receptors and their role in interleukin‐1 actions in murine microglial cells by Pinteaux, Emmanuel, Parker, Lisa C., Rothwell, Nancy J., Luheshi, Giamal N.

“…Interleukin (IL)‐1 is an important mediator of acute brain injury and inflammation, and has been implicated in chronic neurodegeneration. The main source of…”
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Targeting the Networks that Underpin Contiguous Immunity in Asthma and Chronic Obstructive Pulmonary Disease by Sabroe, Ian, Parker, Lisa C, Dockrell, David H, Davies, Donna E, Dower, Steven K, Whyte, Moira K. B

“…Recent advances in the field of innate immunity have driven an important reappraisal of the role of these processes in airway disease. Various strands of…”
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