Search Results - "Parker, Linda"

The Endocannabinoid System and the Brain by MECHOULAM, Raphael, PARKER, Linda A

“…The psychoactive constituent in cannabis, Δ(9)-tetrahydrocannabinol (THC), was isolated in the mid-1960s, but the cannabinoid receptors, CB1 and CB2, and the…”
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Conditioned flavor avoidance and conditioned gaping: Rat models of conditioned nausea by Parker, Linda A.

“…Although rats are incapable of vomiting, they demonstrate profound avoidance of a flavor previously paired with an emetic drug. They also display conditioned…”
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Constituents of Cannabis Sativa by Rock, Erin M, Parker, Linda A

“…The Cannabis sativa plant has been used medicinally and recreationally for thousands of years, but recently only relatively some of its constituents have been…”
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Regulation of nausea and vomiting by cannabinoids and the endocannabinoid system by Sharkey, Keith A., Darmani, Nissar A., Parker, Linda A.

“…Nausea and vomiting (emesis) are important elements in defensive or protective responses that animals use to avoid ingestion or digestion of potentially…”
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Regulation of nausea and vomiting by cannabinoids by Parker, Linda A, Rock, Erin M, Limebeer, Cheryl L

“…Considerable evidence demonstrates that manipulation of the endocannabinoid system regulates nausea and vomiting in humans and other animals. The anti‐emetic…”
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Corrigendum to ’Conditioned flavor avoidance and conditioned gaping: Rat models of conditioned nausea ’[European Journal of Pharmacology Volume 722, 2014, Pages 122–133] by Parker, Linda A.

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Short communication: Tissue distribution of major cannabinoids following intraperitoneal injection in male rats by Lust, Cody A C, Lin, Xinjie, Rock, Erin M, Limebeer, Cheryl L, Parker, Linda A, Ma, David W L

“…Currently, peripheral tissue distribution of cannabinoids after treatment is poorly understood. This pilot study sought to examine the early tissue…”
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Treatment of Patients With Metastatic Cancer Using a Major Histocompatibility Complex Class II-Restricted T-Cell Receptor Targeting the Cancer Germline Antigen MAGE-A3 by Lu, Yong-Chen, Parker, Linda L, Lu, Tangying, Zheng, Zhili, Toomey, Mary Ann, White, Donald E, Yao, Xin, Li, Yong F, Robbins, Paul F, Feldman, Steven A, van der Bruggen, Pierre, Klebanoff, Christopher A, Goff, Stephanie L, Sherry, Richard M, Kammula, Udai S, Yang, James C, Rosenberg, Steven A

“…Purpose Adoptive transfer of genetically modified T cells is being explored as a treatment for patients with metastatic cancer. Most current strategies use…”
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Cannabinoids and Cancer Chemotherapy-Associated Adverse Effects by Ward, Sara Jane, Lichtman, Aron H, Piomelli, Daniele, Parker, Linda A

“…Abstract The use of cannabis is not unfamiliar to many cancer patients, as there is a long history of its use for cancer pain and/or pain, nausea, and cachexia…”
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Cannabidiolic acid methyl ester, a stable synthetic analogue of cannabidiolic acid, can produce 5‐HT1A receptor‐mediated suppression of nausea and anxiety in rats by Pertwee, Roger G, Rock, Erin M, Guenther, Kelsey, Limebeer, Cheryl L, Stevenson, Lesley A, Haj, Christeene, Smoum, Reem, Parker, Linda A, Mechoulam, Raphael

“…Background and Purpose The aim of this study was to compare the abilities of cannabidiolic acid methyl ester (HU‐580) and cannabidiolic acid (CBDA) to enhance…”
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THC alters alters morphology of neurons in medial prefrontal cortex, orbital prefrontal cortex, and nucleus accumbens and alters the ability of later experience to promote structural plasticity by Kolb, Bryan, Li, Yilin, Robinson, Terry, Parker, Linda A.

“…Psychoactive drugs have the ability to alter the morphology of neuronal dendrites and spines and to influence later experience‐dependent structural plasticity…”
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High fructose corn syrup alters behavioural and neurobiological responses to oxycodone in rats by Minhas, Meenu, Limebeer, Cheryl L., Strom, Evan, Parker, Linda A., Leri, Francesco

“…There are indications that sugars in the diet can play a role in vulnerability to opioid abuse. The current study examined a range of neuro-behavioural…”
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A Phase I Study on Adoptive Immunotherapy Using Gene-Modified T Cells for Ovarian Cancer by KERSHAW, Michael H, WESTWARD, Jennifer A, CHEN, Clara C, YANG, James C, ROSENBERG, Steven A, HWU, Patrick, PARKER, Linda L, GANG WANG, ESHHAR, Zelig, MAVROUKAKIS, Sharon A, WHITE, Donald E, WUNDERLICH, John R, CANEVARI, Silvana, ROGERS-FREEZER, Linda

“…Purpose: A phase I study was conducted to assess the safety of adoptive immunotherapy using gene-modified autologous T cells for the treatment of metastatic…”
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Effect of oleoyl glycine and oleoyl alanine on lithium chloride induced nausea in rats and vomiting in shrews by Rock, Erin M., Limebeer, Cheryl L., Smoum, Reem, Mechoulam, Raphael, Parker, Linda A

“…Rationale The fatty acid amide oleoyl glycine (OlGly) and its more stable methylated form oleoyl alanine (OlAla) reduce naloxone-precipitated morphine…”
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Climatology of Deep O+ Dropouts in the Night‐Time F‐Region in Solar Minimum Measured by a Langmuir Probe Onboard the International Space Station by Debchoudhury, Shantanab, Barjatya, Aroh, Minow, Joseph I., Coffey, Victoria N., Parker, Linda N.

“…The Floating Potential Measurement Unit onboard the International Space Station includes a Wide sweeping Langmuir Probe that has been operating in the F‐region…”
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Evaluation of repeated or acute treatment with cannabidiol (CBD), cannabidiolic acid (CBDA) or CBDA methyl ester (HU-580) on nausea and/or vomiting in rats and shrews by Rock, Erin M., Sullivan, Megan T., Collins, Stephen A., Goodman, Hannah, Limebeer, Cheryl L., Mechoulam, Raphael, Parker, Linda A.

“…Rationale When acutely administered intraperitoneally, the non-psychoactive cannabinoid cannabidiol (CBD), its acidic precursor cannabidiolic acid (CBDA) and a…”
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Pharmacokinetics and central accumulation of delta-9-tetrahydrocannabinol (THC) and its bioactive metabolites are influenced by route of administration and sex in rats by Baglot, Samantha L., Hume, Catherine, Petrie, Gavin N., Aukema, Robert J., Lightfoot, Savannah H. M., Grace, Laine M., Zhou, Ruokun, Parker, Linda, Rho, Jong M., Borgland, Stephanie L., McLaughlin, Ryan J., Brechenmacher, Laurent, Hill, Matthew N.

“…Up to a third of North Americans report using cannabis in the prior month, most commonly through inhalation. Animal models that reflect human consumption are…”
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Effect of combined doses of Δ(9)-tetrahydrocannabinol (THC) and cannabidiolic acid (CBDA) on acute and anticipatory nausea using rat (Sprague- Dawley) models of conditioned gaping by Rock, Erin M, Limebeer, Cheryl L, Parker, Linda A

“…Δ(9)-Tetrahydrocannabinol (THC) and cannabidiolic acid (CBDA) found in cannabis both reduce the distressing symptom of nausea, but their combined effects are…”
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Effect of combined oral doses of Δ(9)-tetrahydrocannabinol (THC) and cannabidiolic acid (CBDA) on acute and anticipatory nausea in rat models by Rock, Erin M, Connolly, Cassidy, Limebeer, Cheryl L, Parker, Linda A

“…The purpose of this study was to evaluate the potential of oral combined cannabis constituents to reduce nausea. The objective of this study was to determine…”
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Synergy between cannabidiol, cannabidiolic acid, and delta -tetrahydrocannabinol in the regulation of emesis in the Suncus murinus (house musk shrew) by Rock, Erin M, Parker, Linda A

“…Smoked marijuana contains over 100 different cannabinoids, including the psychoactive compound ...9-tetrahydrocannabinol (THC) and cannabidiol (CBD). THC, CBD,…”
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