Search Results - "Parker, JA"

Alteplase versus heparin in acute pulmonary embolism: randomised trial assessing right-ventricular function and pulmonary perfusion by Goldhaber, S Z, Haire, W D, Feldstein, M L, Miller, M, Toltzis, R, Smith, J L, Taveira da Silva, A M, Come, P C, Lee, R T, Parker, J A

“…Data from a non-randomised study have hinted that in patients with acute pulmonary embolism (PE), thrombolysis followed by heparin more rapidly reverses…”
Get more information

A rapid chemical-genetic screen utilizing impaired movement phenotypes in C. elegans: Input into genetics of neurodevelopmental disorders by Schmeisser, Kathrin, Fardghassemi, Yasmin, Parker, J. Alex

“…Autism spectrum disorder (ASD) is the most common neurodevelopmental disorder with a constantly increasing prevalence. Model organisms may be tools to identify…”
Get full text

Resveratrol rescues mutant polyglutamine cytotoxicity in nematode and mammalian neurons by Parker, J Alex, Abderrahmane, Salima, Tourette, Cendrine, Arango, Margarita, Lambert, Emmanuel, Néri, Christian, Catoire, Hélène

“…We report that Sir2 activation through increased sir-2.1 dosage or treatment with the sirtuin activator resveratrol specifically rescued early neuronal…”
Get full text

Optimal Expectations by Brunnermeier, Markus K., Parker, Jonathan A.

“…Forward-looking agents care about expected future utility flows, and hence have higher current felicity if they are optimistic. This paper studies…”
Get full text

ATP6V0C variants impair V-ATPase function causing a neurodevelopmental disorder often associated with epilepsy by Mattison, Kari A, Tossing, Gilles, Mulroe, Fred, Simmons, Callum, Butler, Kameryn M, Schreiber, Alison, Alsadah, Adnan, Neilson, Derek E, Naess, Karin, Wedell, Anna, Wredenberg, Anna, Sorlin, Arthur, McCann, Emma, Burghel, George J, Menendez, Beatriz, Hoganson, George E, Botto, Lorenzo D, Filloux, Francis M, Aledo-Serrano, Ángel, Gil-Nagel, Antonio, Tatton-Brown, Katrina, Verbeek, Nienke E, van der Zwaag, Bert, Aleck, Kyrieckos A, Fazenbaker, Andrew C, Balciuniene, Jorune, Dubbs, Holly A, Marsh, Eric D, Garber, Kathryn, Ek, Jakob, Duno, Morten, Hoei-Hansen, Christina E, Deardorff, Matthew A, Raca, Gordana, Quindipan, Catherine, van Hirtum-Das, Michele, Breckpot, Jeroen, Hammer, Trine Bjørg, Møller, Rikke S, Whitney, Andrea, Douglas, Andrew G L, Kharbanda, Mira, Brunetti-Pierri, Nicola, Morleo, Manuela, Nigro, Vincenzo, May, Halie J, Tao, James X, Argilli, Emanuela, Sherr, Elliot H, Dobyns, William B, Baines, Richard A, Warwicker, Jim, Parker, J Alex, Banka, Siddharth, Campeau, Philippe M, Escayg, Andrew

“…Abstract The vacuolar H+-ATPase is an enzymatic complex that functions in an ATP-dependent manner to pump protons across membranes and acidify organelles,…”
Get full text

Consumption Risk and the Cross Section of Expected Returns by Parker, Jonathan A., Julliard, Christian

“…This paper evaluates the central insight of the consumption capital asset pricing model that an asset’s expected return is determined by its equilibrium risk…”
Get full text

Consumption Over the Life Cycle by Gourinchas, Pierre-Olivier, Parker, Jonathan A.

“…This paper estimates a structural model of optimal life-cycle consumption expenditures in the presence of realistic labor income uncertainty. We employ…”
Get full text

Near-infrared fluorescent type II quantum dots for sentinel lymph node mapping by Frangioni, John V, Kim, Sungjee, Lim, Yong Taik, Soltesz, Edward G, De Grand, Alec M, Lee, Jaihyoung, Nakayama, Akira, Parker, J Anthony, Mihaljevic, Tomislav, Laurence, Rita G, Dor, Delphine M, Cohn, Lawrence H, Bawendi, Moungi G

“…The use of near-infrared or infrared photons is a promising approach for biomedical imaging in living tissue. This technology often requires exogenous contrast…”
Get full text

ATP6V0C variants impair vacuolar V-ATPase causing a neurodevelopmental disorder often associated with epilepsy by Mattison, KA, Tossing, G, Mulroe, F, Simmons, C, Butler, KM, Schreiber, A, Alsadah, A, Neilson, DE, Naess, K, Wedell, A, Wredenberg, A, Sorlin, A, McCann, E, Burghel, GJ, Menendez, B, Hoganson, GE, Botto, LD, Filloux, FM, Aledo-Serrano, Á, Gil-Nagel, A, Tatton-Brown, K, Verbeek, NE, van Hirtum-Das, M, Breckpot, J, Hammer, TB, Møller, RS, Whitney, A, Douglas, AGL, Kharbanda, M, Brunetti-Pierri, N, Morleo, M, Nigro, V, May, HJ, Tao, JX, Argili, E, Sherr, EH, Dobyns, WB, Consortium, GER, Baines, RA, Warwicker, J, Parker, JA, Banka, S, Campeau, PM, Escayg, A

Get full text

Luxury Goods and the Equity Premium by AÏT-SAHALIA, YACINE, PARKER, JONATHAN A., YOGO, MOTOHIRO

“…This paper evaluates the equity premium using novel data on the consumption of luxury goods. Specifying utility as a nonhomothetic function of both luxury and…”
Get full text

Neuroleptics as therapeutic compounds stabilizing neuromuscular transmission in amyotrophic lateral sclerosis by Patten, Shunmoogum A, Aggad, Dina, Martinez, Jose, Tremblay, Elsa, Petrillo, Janet, Armstrong, Gary Ab, La Fontaine, Alexandre, Maios, Claudia, Liao, Meijiang, Ciura, Sorana, Wen, Xiao-Yan, Rafuse, Victor, Ichida, Justin, Zinman, Lorne, Julien, Jean-Pierre, Kabashi, Edor, Robitaille, Richard, Korngut, Lawrence, Parker, J Alexander, Drapeau, Pierre

“…Amyotrophic lateral sclerosis (ALS) is a rapidly progressing, fatal disorder with no effective treatment. We used simple genetic models of ALS to screen…”
Get full text

The Reaction of Household Consumption to Predictable Changes in Social Security Taxes by Parker, Jonathan A.

“…The key implication of rational expectations and the basic life-cycle/permanent-income hypothesis: that predictable changes in income have no effect on the…”
Get full text

Cystamine and cysteamine increase brain levels of BDNF in Huntington disease via HSJ1b and transglutaminase by Borrell-Pagès, Maria, Canals, Josep M, Cordelières, Fabrice P, Parker, J Alex, Pineda, José R, Grange, Ghislaine, Bryson, Elzbieta A, Guillermier, Martine, Hirsch, Etienne, Hantraye, Philippe, Cheetham, Michael E, Néri, Christian, Alberch, Jordi, Brouillet, Emmanuel, Saudou, Frédéric, Humbert, Sandrine

“…There is no treatment for the neurodegenerative disorder Huntington disease (HD). Cystamine is a candidate drug; however, the mechanisms by which it operates…”
Get full text

Abstract S3-05: Integrated analysis of multidimensional genomic data on CALGB 40601 (Alliance), a randomized neoadjuvant phase III trial of weekly paclitaxel (T) and trastuzumab (H) with or without lapatinib (L) for HER2-positive breast cancer by Tanioka, M, Fan, C, Carey, LA, Hyslop, T, Pitcher, BN, Parker, JA, Hoadley, KA, Henry, NL, Tolaney, S, Dang, C, Krop, IE, Harris, L, Berry, DA, Mardis, E, Perou, CM, Winer, EP, Hudis, CA

“…Abstract Background: RNA profiling and mutational analyses in CALGB 40601 (NCT00770809) found significant impact on pathologic complete response (pCR) rates…”
Get full text

D03Mitochondrial Biogenesis, And Respiratory Chain Assembly And Function, In Skeletal Muscle Of The R6/2 Mouse Model And Human Huntington's Disease by Hering, T, Kojer, K, Birth, N, Lenk, T, Parker, JA, Haider, S, Tabrizi, S J, Taanman, J, Orth, M

“…BackgroundHuntington's disease (HD) primarily affects the brain. However, Huntingtin (HTT) is expressed in peripheral tissues as well. In skeletal muscle, like…”
Get full text

B37Investigation Of Viability And Response To Inflammatory Stimuli In Cultured Human Myotubes Derived From Patients With Huntington's Disease by Parker, JA, Haider, S, Miller, JRC, Brown, S, Robertson, N, Lewis, M, Sillery, E, Nowak, V, Sethi, H, Bjorkqvist, M, Orth, M, Tabrizi, S J

“…BackgroundMuscle atrophy has been well documented in patients with HD and yet its cause is unknown. The presence of a low grade immune response in HD has been…”
Get full text

Precautionary Saving and Consumption Fluctuations by Parker, Jonathan A., Preston, Bruce

“…This paper uses the consumption Euler equation to derive a decomposition of consumption growth into four sources. These four sources are new information, and…”
Get full text

Expanded Polyglutamines in Caenorhabditis elegans Cause Axonal Abnormalities and Severe Dysfunction of PLM Mechanosensory Neurons without Cell Death by Parker, J. Alex, Connolly, John B., Wellington, Cheryll, Hayden, Michael, Dausset, Jean, Neri, Christian

“…Huntington's disease (HD) is a dominant neurodegenerative disease caused by polyglutamine (polyQ) expansion in the protein huntingtin (htt). HD pathogenesis…”
Get full text

B19The Wnt Receptor Ryk Reduces Neuronal Resistance Capacity By Repressing Foxo Activity During The Early Phases Of Huntingtin Pathogenicity by Tourette, C, Farina, F, Vazquez-Manrique, R P, Orfila, A M, Voisin, J, Hernandez, S, Offner, N, Parker, JA, Menet, S, Kim, J, Lyu, J, Choi, SH, Cormier, K, Edgerly, C K, Bordiuk, O L, Smith, K, Louise, A, Halford, M, Stacker, S, Vert, J P, Ferrante, R J, Lu, W, Neri, C

“…BackgroundThe ability of neurons to cope with the chronic stress induced by mutant protein expression in Huntington's disease (HD) may determine the course of…”
Get full text

Long-term effects of surgical angiogenic therapy with fibroblast growth factor 2 protein by Ruel, Marc, Laham, Roger J., Parker, J.Anthony, Post, Mark J., Ware, J.Anthony, Simons, Michael, Sellke, Frank W.

“…Objective: The long-term effects of surgical fibroblast growth factor 2 therapy are examined. Methods: In a randomized, double-blind study, fibroblast growth…”
Get full text