Search Results - "Parker, Brittany C"

Single-cell analysis of human glioma and immune cells identifies S100A4 as an immunotherapy target by Abdelfattah, Nourhan, Kumar, Parveen, Wang, Caiyi, Leu, Jia-Shiun, Flynn, William F., Gao, Ruli, Baskin, David S., Pichumani, Kumar, Ijare, Omkar B., Wood, Stephanie L., Powell, Suzanne Z., Haviland, David L., Parker Kerrigan, Brittany C., Lang, Frederick F., Prabhu, Sujit S., Huntoon, Kristin M., Jiang, Wen, Kim, Betty Y. S., George, Joshy, Yun, Kyuson

“…A major rate-limiting step in developing more effective immunotherapies for GBM is our inadequate understanding of the cellular complexity and the molecular…”
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MiR-506 suppresses proliferation and induces senescence by directly targeting the CDK4/6-FOXM1 axis in ovarian cancer by Liu, Guoyan, Sun, Yan, Ji, Ping, Li, Xia, Cogdell, David, Yang, Da, Parker Kerrigan, Brittany C, Shmulevich, Ilya, Chen, Kexin, Sood, Anil K, Xue, Fengxia, Zhang, Wei

“…Ovarian carcinoma is the most lethal gynaecological malignancy. Better understanding of the molecular pathogenesis of this disease and effective targeted…”
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Characterization of patient-derived bone marrow human mesenchymal stem cells as oncolytic virus carriers for the treatment of glioblastoma by Shimizu, Yuzaburo, Gumin, Joy, Gao, Feng, Hossain, Anwar, Shpall, Elizabeth J, Kondo, Akihide, Parker Kerrigan, Brittany C, Yang, Jing, Ledbetter, Daniel, Fueyo, Juan, Gomez-Manzano, Candelaria, Lang, Frederick F

“…Delta-24-RGD is an oncolytic adenovirus that is capable of replicating in and killing human glioma cells. Although intratumoral delivery of Delta-24-RGD can be…”
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Post-transcriptional regulatory network of epithelial-to-mesenchymal and mesenchymal-to-epithelial transitions by Guo, Fei, Parker Kerrigan, Brittany C, Yang, Da, Hu, Limei, Shmulevich, Ilya, Sood, Anil K, Xue, Fengxia, Zhang, Wei

“…Epithelial-to-mesenchymal transition (EMT) and its reverse process, mesenchymal-to-epithelial transition (MET), play important roles in embryogenesis, stem…”
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Tumor Vaccines for Malignant Gliomas by Srinivasan, Visish M., Ferguson, Sherise D., Lee, Sungho, Weathers, Shiao-Pei, Kerrigan, Brittany C. Parker, Heimberger, Amy B.

“…Despite continued research efforts, glioblastoma multiforme (GBM) remains the deadliest brain tumor. Immunotherapy offers a novel way to treat this disease,…”
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Retinal pigment epithelial cell death by the alternative complement cascade: role of membrane regulatory proteins, calcium, PKC, and oxidative stress by Yang, Ping, Baciu, Peter, Kerrigan, Brittany C Parker, Etheridge, Menna, Sung, Eric, Toimil, Brett A, Berchuck, Jacob E, Jaffe, Glenn J

“…Retinal pigment epithelial (RPE) cell death is an important feature of the advanced forms of AMD. Complement alternative pathway (AP) activation is associated…”
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Mesenchymal stromal cells for the delivery of oncolytic viruses in gliomas by Parker Kerrigan, Brittany C, Shimizu, Yuzaburo, Andreeff, Michael, Lang, Frederick F

“…Abstract Mesenchymal stromal cells (MSCs) are a type of adult stem cell that has been exploited for the treatment of a variety of diseases, including cancer…”
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Ionizing radiation augments glioma tropism of mesenchymal stem cells by Thomas, Jonathan G, Parker Kerrigan, Brittany C, Hossain, Anwar, Gumin, Joy, Shinojima, Naoki, Nwajei, Felix, Ezhilarasan, Ravesanker, Love, Patrice, Sulman, Erik P, Lang, Frederick F

“…OBJECTIVE Mesenchymal stem cells (MSCs) have been shown to localize to gliomas after intravascular delivery. Because these cells home to areas of tissue…”
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HSP90-CDC37 functions as a chaperone for the oncogenic FGFR3-TACC3 fusion by Li, Tao, Mehraein-Ghomi, Farideh, Forbes, M. Elizabeth, Namjoshi, Sanjeev V., Ballard, E. Ashley, Song, Qianqian, Chou, Ping-Chieh, Wang, Xuya, Parker Kerrigan, Brittany C., Lang, Frederick F., Lesser, Glenn, Debinski, Waldemar, Yang, Xuejun, Zhang, Wei

“…The FGFR3-TACC3 (F3-T3) fusion gene was discovered as an oncogenic molecule in glioblastoma and bladder cancers, and has subsequently been found in many cancer…”
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Microcatheter delivery of neurotherapeutics: compatibility with mesenchymal stem cells by Srinivasan, Visish M, Gumin, Joy, Camstra, Kevin M, Chen, Stephen R, Johnson, Jeremiah N, Shimizu, Yuzaburo, Parker Kerrigan, Brittany C, Shpall, Elizabeth J, Lang, Frederick F, Kan, Peter

“…Bone marrow-derived human mesenchymal stem cells (BM-hMSCs) have been used in clinical trials for the treatment of several neurological disorders. MSCs have…”
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An immune-competent, replication-permissive Syrian Hamster glioma model for evaluating Delta-24-RGD oncolytic adenovirus by Phillips, Lynette M, Li, Shoudong, Gumin, Joy, Daou, Marc, Ledbetter, Daniel, Yang, Jing, Singh, Sanjay, Parker Kerrigan, Brittany C, Hossain, Anwar, Yuan, Ying, Gomez-Manzano, Candelaria, Fueyo, Juan, Lang, Frederick F

“…Abstract Background Oncolytic adenoviruses are promising new treatments against solid tumors, particularly for glioblastoma (GBM), and preclinical models are…”
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Endovascular Selective Intra-Arterial Infusion of Mesenchymal Stem Cells Loaded With Delta-24 in a Canine Model by Srinivasan, Visish M, Gumin, Joy, Camstra, Kevin M, Collins, Dalis E, Chen, Melissa M, Shpall, Elizabeth J, Parker Kerrigan, Brittany C, Johnson, Jeremiah N, Chen, Stephen R, Fueyo, Juan, Gomez-Manzano, Cande, Lang, Frederick F, Kan, Peter

“…Abstract BACKGROUND Delta-24-RGD, an oncolytic adenovirus, shows promise against glioblastoma. To enhance virus delivery, we recently demonstrated that human…”
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Emergence of FGFR family gene fusions as therapeutic targets in a wide spectrum of solid tumours by Parker, Brittany C, Engels, Manon, Annala, Matti, Zhang, Wei

“…The emergence of fibroblast growth factor receptor (FGFR) family fusions across diverse cancers has brought attention to FGFR‐derived cancer therapies. The…”
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Targeting the Tumor Microenvironment in Brain Metastasis by Giridharan, Nisha, Glitza Oliva, Isabella C., O’Brien, Barbara J., Parker Kerrigan, Brittany C., Heimberger, Amy B., Ferguson, Sherise D.

“…Dynamic interplay between cancer cells and the surrounding microenvironment is a feature of the metastatic process. Successful metastatic brain colonization…”
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The genomic alterations in glioblastoma influence the levels of CSF metabolites by Wang, Daniel H, Fujita, Yoko, Dono, Antonio, Rodriguez Armendariz, Ana G, Shah, Mauli, Putluri, Nagireddy, Pichardo-Rojas, Pavel S, Patel, Chirag B, Zhu, Jay-Jiguang, Huse, Jason T, Parker Kerrigan, Brittany C, Lang, Frederick F, Esquenazi, Yoshua, Ballester, Leomar Y

“…Cerebrospinal fluid (CSF) analysis is underutilized in patients with glioblastoma (GBM), partly due to a lack of studies demonstrating the clinical utility of…”
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Fusion genes in solid tumors: an emerging target for cancer diagnosis and treatment by Parker, Brittany C, Zhang, Wei

“…Studies over the past decades have uncovered fusion genes, a class of oncogenes that provide immense diagnostic and therapeutic advantages because of their…”
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RNAi technology targeting the FGFR3-TACC3 fusion breakpoint: an opportunity for precision medicine by Parker Kerrigan, Brittany C, Ledbetter, Daniel, Kronowitz, Matthew, Phillips, Lynette, Gumin, Joy, Hossain, Anwar, Yang, Jing, Mendt, Mayela, Singh, Sanjay, Cogdell, David, Ene, Chibawanye, Shpall, Elizabeth, Lang, Frederick F

“…Abstract Background Fusion genes form as a result of abnormal chromosomal rearrangements linking previously separate genes into one transcript. The FGFR3-TACC3…”
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The tumorigenic FGFR3-TACC3 gene fusion escapes miR-99a regulation in glioblastoma by Parker, Brittany C, Annala, Matti J, Cogdell, David E, Granberg, Kirsi J, Sun, Yan, Ji, Ping, Li, Xia, Gumin, Joy, Zheng, Hong, Hu, Limei, Yli-Harja, Olli, Haapasalo, Hannu, Visakorpi, Tapio, Liu, Xiuping, Liu, Chang-Gong, Sawaya, Raymond, Fuller, Gregory N, Chen, Kexin, Lang, Frederick F, Nykter, Matti, Zhang, Wei

“…Fusion genes are chromosomal aberrations that are found in many cancers and can be used as prognostic markers and drug targets in clinical practice. Fusions…”
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Immune modulatory nanoparticle therapeutics for intracerebral glioma by Yaghi, Nasser K, Wei, Jun, Hashimoto, Yuuri, Kong, Ling-Yuan, Gabrusiewicz, Konrad, Nduom, Edjah K, Ling, Xiaoyang, Huang, Neal, Zhou, Shouhao, Kerrigan, Brittany C Parker, Levine, Jonathan M, Fajt, Virginia R, Levine, Gwendolyn, Porter, Brian F, Marcusson, Eric G, Tachikawa, Kiyoshi, Chivukula, Padmanabh, Webb, David C, Payne, Joseph E, Heimberger, Amy B

“…Previously we showed therapeutic efficacy of unprotected miR-124 in preclinical murine models of glioblastoma, including in heterogeneous genetically…”
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Linking inflammation and cancer: the unexpected SYK world by Fueyo, Juan, Alonso, Marta M, Parker Kerrigan, Brittany C, Gomez-Manzano, Candelaria

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