Search Results - "Parke, D V"

Interaction of a series of nitriles with the alcohol-inducible isoform of P450: computer analysis of structure-activity relationships by Lewis, D F, Ioannides, C, Parke, D V

“…1. Structural studies are reported on a series of 20 nitriles of varying rates of P4502E-mediated oxidative metabolism. 2. Parameters of molecular and…”
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Cytochromes P450 and Species Differences in Xenobiotic Metabolism and Activation of Carcinogen by David F. V. Lewis, Ioannides, Costas, Parke, Dennis V.

“…The importance of cytochrome P450 isoforms to species differences in the metabolism of foreign compounds and activation of procarcinogens has been identified…”
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The Cytochromes P450 and Mechanisms of Chemical Carcinogenesis by Parke, Dennis V.

“…This article reviews mechanisms of chemical carcinogenesis, from metabolic activation and generation of reactive oxygen species by cytochromes P4511 and P4502E…”
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Induction of cytochrome P4501 as an indicator of potential chemical carcinogenesis by Ioannides, C, Parke, D V

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The cytochrome P450 I gene family of microsomal hemoproteins and their role in the metabolic activation of chemicals by Ioannides, C, Parke, D V

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The toxicity of benzene and its metabolism and molecular pathology in human risk assessment by Yardley-Jones, A, Anderson, D, Parke, D V

“…Benzene, a common industrial chemical and a component of gasoline, is radiomimetic and exposure may lead progressively to aplastic anaemia, leukaemia, and…”
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Quantitative structure–activity relationships in a series of endogenous and synthetic steroids exhibiting induction of CYP3A activity and hepatomegaly associated with increased DNA synthesis by Lewis, D.F.V., Ioannides, C., Parke, D.V., Schulte-Hermann, R.

“…The results of a quantitative structure–activity relationship (QSAR) study on a total of 14 steroids exhibiting induction of a CYP3A-associated activity and…”
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Personal reflections on 50 years of study of benzene toxicology by Parke, D V

“…The metabolism of benzene is reviewed, and the objectives of a quantitative balance study begun in 1945 are outlined; problems of toxicology and metabolism…”
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An Improved and Updated Version of the Compact Procedure for the Evaluation of P450-Mediated Chemical Activation by Lewis, D. F. V., Ioannides, C., Parke, D. V.

“…COMPACT (Computer-Optimized Molecular Parametric Analysis of Chemical Toxicity) is a structural-based procedure for the prediction of potential toxicity and…”
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Molecular modelling of CYP2E1 enzymes from rat, mouse and man: An explanation for species differences in butadiene metabolism and potential carcinogenicity, and rationalization of CYP2E substrate specificity by Lewis, David F.V., Bird, Michael G., Parke, Dennis V.

“…Molecular modelling of substrates of cytochrome P4502E1 (CYP2E1) within the putative active site region of CYP2E1 constructed from the CYP102 crystal structure…”
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Further evaluation of COMPACT, the molecular orbital approach for the prospective safety evaluation of chemicals by Lewis, D.F.V, Ioannides, C, Parke, D.V

“…The molecular dimensions and electronic structures of the first group of 100 US NCI/NTP miscellaneous chemicals, evaluated for potential carcinogenicity by…”
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Effects of ether anaesthesia and fasting on various cytochromes P450 of rat liver and kidney by Liu, P T, Ioannides, C, Shavila, J, Symons, A M, Parke, D V

“…Fed and fasted, male, Wistar albino rats exposed to light ether anaesthesia and killed immediately or after 30 or 120 min recovery were compared with…”
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The 1990 Pharmaceutical Manufacturers Association of Canada keynote lecture. The role of the cytochromes P450 in the detoxication and activation of drugs and other chemicals by Parke, D V, Ioannides, C, Lewis, D F

“…The roles of the cytochromes P450 are reviewed, with emphasis on their involvement in the detoxication of drugs and chemicals, the activation of carcinogens,…”
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Interactions of imidazole antifungal agents with purified cytochrome P-450 proteins by Rodrigues, A D, Gibson, G G, Ioannides, C, Parke, D V

“…The imidazole N-substituted antifungal agents ketoconazole, miconazole and clotrimazole have been shown to be potent inhibitors of oxidative metabolism by both…”
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Metal toxicity in two rodent species and redox potential: evaluation of quantitative structure-activity relationships by Lewis, D.F.V, Dobrota, M, Taylor, M.G, Parke, D.V

“…A quantitative structure-activity relationship study of acute toxicity in the mouse and rat is described for the soluble salts of a relatively large number of…”
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The cytochromes P-448--a unique family of enzymes involved in chemical toxicity and carcinogenesis by Ioannides, C, Parke, D V

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A History of Drug Metabolism in the United Kingdom by Parke, Dennis V.

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Spontaneous development of fatty liver in ferrets in a toxicology study by Shavila, J., King, L.J., Parke, D.V.

“…Ferrets were maintained for 12 months on different diets (A, meat and biscuit; B, all meat; C, meat and fish; D, high fibre) to ascertain the cause of…”
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Molecular modelling of cytochrome CYP1A1: a putative access channel explains differences in induction potency between the isomers benzo(a)pyrene and benzo(e)pyrene, and 2- and 4-acetylaminofluorene by Lewis, D F, Ioannides, C, Parke, D V

“…The present studies were undertaken to provide a rationale for the observation that benzo(a)pyrene and 2-acetylaminofluorene induce the hepatic CYP1A1 protein,…”
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Studies in surgical trauma: oxidative stress in ischaemia-reperfusion of rat liver by Liu, P T, Symons, A M, Howarth, J A, Boulter, P S, Parke, D V

“…1. Hypovolaemic shock associated with surgical trauma has been studied in a rat liver ischaemia-reperfusion model by determination of oxidative stress, lipid…”
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