Search Results - "Park, Woong Ryeon"

Role of Dimerized C16orf74 in Aggressive Pancreatic Cancer: A Novel Therapeutic Target by Kushibiki, Toshihiro, Nakamura, Toru, Tsuda, Masumi, Tsuchikawa, Takahiro, Hontani, Koji, Inoko, Kazuho, Takahashi, Mizuna, Asano, Toshimichi, Okamura, Keisuke, Murakami, Soichi, Kurashima, Yo, Ebihara, Yuma, Noji, Takehiro, Nakanishi, Yoshitsugu, Tanaka, Kimitaka, Maishi, Nako, Sasaki, Katsunori, Park, Woong-Ryeon, Shichinohe, Toshiaki, Hida, Kyoko, Tanaka, Shinya, Hirano, Satoshi

“…Over the past 30 years, the therapeutic outcome for pancreatic ductal adenocarcinoma (PDAC) has remained stagnant due to the lack of effective treatments. We…”
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A critical role for IL‐12 in CCR5 induction on T cell receptor‐triggered mouse CD4+ and CD8+ T cells by Iwasaki, Masayuki, Mukai, Takao, Gao, Ping, Park, Woong‐Ryeon, Nakajima, Chigusa, Tomura, Michio, Fujiwara, Hiromi, Hamaoka, Toshiyuki

“…Despite increasing evidence for the role of the chemokine system in leukocyte trafficking, the mechanism underlying the induction of chemokine receptors is…”
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p53CSV, a novel p53-inducible gene involved in the p53-dependent cell-survival pathway by PARK, Woong-Ryeon, NAKAMURA, Yusuke

“…Although a number of p53 target genes have been identified, the mechanisms of p53-dependent activities that determine cellular survival or death are still not…”
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CD28 costimulation is required not only to induce IL‐12 receptor but also to render Janus kinases / STAT4 responsive to IL‐12 stimulation in TCR‐triggered T cells by Park, Woong‐Ryeon, Park, Cheung‐Seog, Tomura, Michio, Ahn, Hyun‐Jong, Nakahira, Yasukiyo, Iwasaki, Masayuki, Gao, Ping, Abe, Ryo, Hamaoka, Toshiyuki, Fujiwara, Hiromi

“…The activation of resting T cells for the acquisition of various functions depends on whether CD28 costimulatory signals are provided upon T cell receptor…”
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Induction of the chemokine receptor CXCR3 on TCR‐stimulated T cells: dependence on the release from persistent TCR‐triggering and requirement for IFN‐γ stimulation by Nakajima, Chigusa, Mukai, Takao, Yamaguchi, Nobuya, Morimoto, Yasunari, Park, Woong‐Ryeon, Iwasaki, Masayuki, Gao, Ping, Ono, Shiro, Fujiwara, Hiromi, Hamaoka, Toshiyuki

“…The chemokine receptor CXCR3 has been shown to play a key role in the recruitment of T cells to sites of inflammation such as allografts. Here, we investigated…”
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Molecular Mechanisms Underlying Differential Contribution of CD28 Versus Non-CD28 Costimulatory Molecules to IL-2 Promoter Activation by Zhou, Xu-Yu, Yashiro-Ohtani, Yumi, Nakahira, Masakiyo, Park, Woong Ryeon, Abe, Ryo, Hamaoka, Toshiyuki, Naramura, Mayumi, Gu, Hua, Fujiwara, Hiromi

“…T cell costimulation via CD28 and other (non-CD28) costimulatory molecules induces comparable levels of [(3)H]TdR incorporation, but fundamentally differs in…”
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A mechanism underlying STAT4‐mediated up‐regulation of IFN‐γ induction inTCR‐triggered T cells by Park, Woong‐Ryeon, Nakahira, Masakiyo, Sugimoto, Naotoshi, Bian, Yang, Yashiro‐Ohtani, Yumi, Zhou, Xu‐Yu, Yang, Yi‐Fu, Hamaoka, Toshiyuki, Fujiwara, Hiromi

“…IL‐12 promotes Th1 development/IFN‐γ expression by activating STAT4. However, it is still unclear how STAT4 elicits IFN‐γ promoter activation. Here, we…”
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Two Functional Subsets of FOXP3 + Regulatory T Cells in Human Thymus and Periphery by Ito, Tomoki, Hanabuchi, Shino, Wang, Yi-Hong, Park, Woong Ryeon, Arima, Kazuhiko, Bover, Laura, Qin, F. Xiao-Feng, Gilliet, Michel, Liu, Yong-Jun

“…Previous studies suggest that thymus produces a homogenous population of natural regulatory T (Treg) cells that express a transcriptional factor FOXP3 and…”
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Requirement for distinct Janus kinases and STAT proteins in T cell proliferation versus IFN-gamma production following IL-12 stimulation by Ahn, H J, Tomura, M, Yu, W G, Iwasaki, M, Park, W R, Hamaoka, T, Fujiwara, H

“…While IL-12 is known to activate JAK2 and TYK2 and induce the phosphorylation of STAT4 and STAT3, little is known regarding how the activation of these…”
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Reversible CD8 expression induced by common cytokine receptor γ chain-dependent cytokines in a cloned CD4+ Th1 cell line by Park, Cheung-Seog, Yang, Yi-Fu, Zhou, Xu-Yu, Toyooka, Kazuhito, Yashiro-Ohtani, Yumi, Park, Woong-Ryeon, Tomura, Michio, Tai, Xu-Guang, Hamaoka, Toshiyuki, Fujiwara, Hiromi

“…T cells that are intrathymically lineage committed are believed to maintain their CD4 or CD8 co-receptor expression. Here, we investigated whether intrathymic…”
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DIFFERENTIAL EFFECTS OF N-ACETYL-L-CYSTEINE ON IL-2- VS IL-12-DRIVEN PROLIFERATION OF A T CELL CLONE: IMPLICATIONS FOR DISTINCT SIGNALLING PATHWAYS by Park, Cheung-Seog, Park, Woong-Ryeon, Sugimoto, Naotoshi, Nakahira, Masakiyo, Ahn, Hyun-Jong, Hamaoka, Toshiyuki, Ohta, Tsunetaka, Kurimoto, Masashi, Fujiwara, Hiromi

“…Using a T cell clone (2D6) capable of responding to IL-2 and IL-12, we compared the effects of NAC on IL-2 and IL-12-driven T cell proliferation. Addition of…”
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Synergy of IL-12 and IL-18 for IFN-gamma gene expression: IL-12-induced STAT4 contributes to IFN-gamma promoter activation by up-regulating the binding activity of IL-18-induced activator protein 1 by Nakahira, Masakiyo, Ahn, Hyun-Jong, Park, Woong-Ryeon, Gao, Ping, Tomura, Michio, Park, Cheung-Seog, Hamaoka, Toshiyuki, Ohta, Tsunetaka, Kurimoto, Masashi, Fujiwara, Hiromi

“…IL-12 and IL-18 synergistically enhance IFN-gamma mRNA transcription by activating STAT4 and AP-1, respectively. However, it is still unknown how STAT4/AP-1…”
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Neutralization of IFN‐inducible protein 10/CXCL10 exacerbates experimental autoimmune encephalomyelitis by Narumi, Shosaku, Kaburaki, Toshikatu, Yoneyama, Hiroyuki, Iwamura, Hiroyuki, Kobayashi, Yuko, Matsushima, Kouji

“…We examined the effect of a monoclonal antibody (mAb) against interferon (IFN)‐inducible protein 10 (IP‐10)/CXCL10 on the development of experimental…”
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A mechanism underlying STAT4-mediated up-regulation of IFN-³ induction inTCR-triggered T cells by Park, Woong-Ryeon, Nakahira, Masakiyo, Sugimoto, Naotoshi, Bian, Yang, Yashiro-Ohtani, Yumi, Xu-Yu, Zhou, Yi-Fu, Yang, Hamaoka, Toshiyuki, Fujiwara, Hiromi

“…IL-12 promotes Th1 development/IFN-³ expression by activating STAT4. However, it is still unclear how STAT4 elicits IFN-³ promoter activation. Here, we…”
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Reversible CD8 expression induced by common cytokine receptor gamma chain-dependent cytokines in a cloned CD4(+) T(h)1 cell line by Park, Cheung-Seog, Yang, Yi-Fu, Zhou, Xu-Yu, Toyooka, Kazuhito, Yashiro-Ohtani, Yumi, Park, Woong-Ryeon, Tomura, Michio, Tai, Xu-Guang, Hamaoka, Toshiyuki, Fujiwara, Hiromi

“…T cells that are intrathymically lineage committed are believed to maintain their CD4 or CD8 co-receptor expression. Here, we investigated whether intrathymic…”
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Synergy of IL-12 and IL-18 for IFN-{gamma} Gene Expression: IL-12-Induced STAT4 Contributes to IFN-{gamma} Promoter Activation by Up-Regulating the Binding Activity of IL-18-Induced Activator Protein 1 by Nakahira, Masakiyo, Ahn, Hyun-Jong, Park, Woong-Ryeon, Gao, Ping, Tomura, Michio, Park, Cheung-Seog, Hamaoka, Toshiyuki, Ohta, Tsunetaka, Kurimoto, Masashi, Fujiwara, Hiromi

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Requirement for Distinct Janus Kinases and STAT Proteins in T Cell Proliferation Versus IFN-{gamma} Production Following IL-12 Stimulation by Ahn, Hyun-Jong, Tomura, Michio, Yu, Wen-Gong, Iwasaki, Masayuki, Park, Woong-Ryeon, Hamaoka, Toshiyuki, Fujiwara, Hiromi

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