Search Results - "Park, Serk In"

Metformin overcomes resistance to cisplatin in triple-negative breast cancer (TNBC) cells by targeting RAD51 by Lee, Jung Ok, Kang, Min Ju, Byun, Won Seok, Kim, Shin Ae, Seo, Il Hyeok, Han, Jeong Ah, Moon, Ji Wook, Kim, Ji Hae, Kim, Su Jin, Lee, Eun Jung, In Park, Serk, Park, Sun Hwa, Kim, Hyeon Soo

“…Chemotherapy is a standard therapeutic regimen to treat triple-negative breast cancer (TNBC); however, chemotherapy alone does not result in significant…”
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Osteal macrophages support physiologic skeletal remodeling and anabolic actions of parathyroid hormone in bone by Cho, Sun Wook, Soki, Fabiana N., Koh, Amy J., Eber, Matthew R., Entezami, Payam, In Park, Serk, van Rooijen, Nico, McCauley, Laurie K.

“…Cellular subpopulations in the bone marrow play distinct and unexplored functions in skeletal homeostasis. This study delineated a unique role of osteal…”
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Targeting SRC family kinases inhibits growth and lymph node metastases of prostate cancer in an orthotopic nude mouse model by Park, Serk In, Zhang, Jing, Phillips, Kacy A, Araujo, John C, Najjar, Amer M, Volgin, Andrei Y, Gelovani, Juri G, Kim, Sun-Jin, Wang, Zhengxin, Gallick, Gary E

“…Aberrant expression and/or activity of members of the Src family of nonreceptor protein tyrosine kinases (SFK) are commonly observed in progressive stages of…”
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Interleukin-7 Contributes to the Invasiveness of Prostate Cancer Cells by Promoting Epithelial–Mesenchymal Transition by Seol, Min A., Kim, Jin-Hee, Oh, Keunhee, Kim, Gwanghun, Seo, Myung Won, Shin, Young-Kyoung, Sim, Ji Hyun, Shin, Hyun Mu, Seo, Bo Yeon, Lee, Dong-Sup, Ku, Ja-Lok, Han, Ilkyu, Kang, Insoo, Park, Serk In, Kim, Hang-Rae

“…Precise mechanisms underlying interleukin-7 (IL-7)-mediated tumor invasion remain unclear. Thus, we investigated the role of IL-7 in tumor invasiveness using…”
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AFAP-110 is overexpressed in prostate cancer and contributes to tumorigenic growth by regulating focal contacts by Zhang, Jing, Park, Serk In, Artime, Marlene C, Summy, Justin M, Shah, Ami N, Bomser, Joshua A, Dorfleutner, Andrea, Flynn, Daniel C, Gallick, Gary E

“…The actin filament-associated protein AFAP-110 is an actin cross-linking protein first identified as a substrate of the viral oncogene v-Src. AFAP-110…”
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Real‐Time Live Imaging of Osteoclast Activation via Cathepsin K Activity in Bone Diseases by Koo, Seyoung, Lee, Eun Jung, Xiong, Hao, Yun, Da Hyeon, McDonald, Michelle M., Park, Serk In, Kim, Jong Seung

“…Intravital fluorescence imaging of functional osteoclasts within their intact disease context provides valuable insights into the intricate biology at the…”
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Dual targeting c-met and VEGFR2 in osteoblasts suppresses growth and osteolysis of prostate cancer bone metastasis by Lee, Changki, Whang, Young Mi, Campbell, Preston, Mulcrone, Patrick L., Elefteriou, Florent, Cho, Sun Wook, Park, Serk In

“…Prostate cancer characteristically induces osteoblastic bone metastasis, for which no therapies are available. A dual kinase inhibitor of c-Met and VEGFR-2…”
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Cover Picture: Real‐Time Live Imaging of Osteoclast Activation via Cathepsin K Activity in Bone Diseases (Angew. Chem. Int. Ed. 6/2024) by Koo, Seyoung, Lee, Eun Jung, Xiong, Hao, Yun, Da Hyeon, McDonald, Michelle M., Park, Serk In, Kim, Jong Seung

“…A novel fluorogenic probe for imaging osteoclasts, the major culprit in pathologic bone destruction, is unveiled by Jong Seung Kim, Serk In Park et al. in…”
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Circulating Osteocalcin‐Positive Cells as a Novel Diagnostic Biomarker for Bone Metastasis in Breast Cancer Patients by Lee, Kyung‐Hun, Lee, Kyoung Jin, Kim, Tae‐Yong, Hutomo, Febby, Sun, Hyun Jin, Cheon, Gi Jeong, Park, Serk In, Cho, Sun Wook, Im, Seock‐Ah

“…ABSTRACT Current diagnosis of bone metastasis (BM) in breast cancer relies on structural changes of bone that occur only in the advanced stage. A sensitive…”
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Development and characterization of gemcitabine-resistant pancreatic tumor cells by Shah, Ami N, Summy, Justin M, Zhang, Jing, Park, Serk In, Parikh, Nila U, Gallick, Gary E

“…Pancreatic cancer is an exceptionally lethal disease with an annual mortality nearly equivalent to its annual incidence. This dismal rate of survival is due to…”
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A Selective FGFR inhibitor AZD4547 suppresses RANKL/M-CSF/OPG-dependent ostoclastogenesis and breast cancer growth in the metastatic bone microenvironment by Kang, Jinho, Choi, Yoon Ji, Seo, Bo Yeon, Jo, Ukhyun, Park, Serk In, Kim, Yeul Hong, Park, Kyong Hwa

“…Aberrant activation of fibroblast growth factor receptor (FGFR) signalling contributes to progression and metastasis of many types of cancers including breast…”
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Depletion of NBR1 in urothelial carcinoma cells enhances rapamycin‐induced apoptosis through impaired autophagy and mitochondrial dysfunction by Kim, Myeong Joo, Hwang, Gwang Yong, Cho, Min Ji, Chi, Byung Hoon, Park, Serk In, Chang, In Ho, Whang, Young Mi

“…Rapamycin is well‐recognized in the clinical therapeutic intervention for patients with cancer by specifically targeting mammalian target of rapamycin (mTOR)…”
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Liposome-Encapsulated Bacillus Calmette-Guérin Cell Wall Skeleton Enhances Antitumor Efficiency for Bladder Cancer In Vitro and In Vivo via Induction of AMP-Activated Protein Kinase by Whang, Young Mi, Yoon, Da Hyeon, Hwang, Gwang Yong, Yoon, Hoyub, Park, Serk In, Choi, Young Wook, Chang, In Ho

“…The Bacillus Calmette-Guérin cell wall skeleton (BCG-CWS), the main immune active center of BCG, is a potent candidate non-infectious immunotherapeutic drug…”
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The multifaceted actions of PTHrP in skeletal metastasis by Soki, Fabiana N, Park, Serk In, McCauley, Laurie K

“…PTHrP, identified during the elucidation of mediators of malignancy-induced hypercalcemia, plays numerous roles in normal physiology as well as pathological…”
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Activation of NF-kappa B signaling promotes growth of prostate cancer cells in bone by Jin, Renjie, Sterling, Julie A, Edwards, James R, DeGraff, David J, Lee, Changki, Park, Serk In, Matusik, Robert J

“…Patients with advanced prostate cancer almost invariably develop osseous metastasis. Although many studies indicate that the activation of NF-κB signaling…”
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Targeted deletion of CD244 on monocytes promotes differentiation into anti-tumorigenic macrophages and potentiates PD-L1 blockade in melanoma by Kim, Jeongsoo, Kim, Tae-Jin, Chae, Sehyun, Ha, Hyojeong, Park, Yejin, Park, Sunghee, Yoon, Chul Joo, Lim, Seon Ah, Lee, Hyemin, Kim, Jiyoung, Kim, Jungwon, Im, Kyungtaek, Lee, Kyunghye, Kim, Jeongmin, Kim, Daham, Lee, Eunju, Shin, Min Hwa, Park, Serk In, Rhee, Inmoo, Jung, Keehoon, Lee, Jeewon, Lee, Keun Hwa, Hwang, Daehee, Lee, Kyung-Mi

“…In the myeloid compartment of the tumor microenvironment, CD244 signaling has been implicated in immunosuppressive phenotype of monocytes. However, the precise…”
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Dissecting the Role of Bone Marrow Stromal Cells on Bone Metastases by Buenrostro, Denise, Park, Serk In, Sterling, Julie A.

“…Tumor-induced bone disease is a dynamic process that involves interactions with many cell types. Once metastatic cancer cells reach the bone, they are in…”
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Antimicrobial activity of NO-releasing compounds against periodontal pathogens by Shim, Ji Suk, Park, Dong-Sik, Baek, Dong-Heon, Jha, Nayansi, Park, Serk In, Yun, Hyoung Jin, Kim, Won Jong, Ryu, Jae Jun

“…This study describes the successful synthesis of nitric oxide (NO)-releasing compounds with biodegradable and injectable properties and demonstrates that the…”
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Mobilization of monocytic myeloid-derived suppressor cells is regulated by PTH1R activation in bone marrow stromal cells by Lee, Eun Jung, Lee, Kyoung Jin, Jung, Seungpil, Park, Kyong Hwa, Park, Serk In

“…Myeloid-derived suppressor cells (MDSCs) are bone marrow (BM)-derived immunosuppressive cells in the tumor microenvironment, but the mechanism of MDSC…”
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Nuclear localization of parathyroid hormone-related peptide confers resistance to anoikis in prostate cancer cells by Park, Serk In, McCauley, Laurie K

“…Prostate cancer remains a leading cause of cancer-related death in men, largely attributable to distant metastases, most frequently to bones. Despite intensive…”
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