Search Results - "Park, Saegwang"

The Therapeutic Effect of Anti-HER2/neu Antibody Depends on Both Innate and Adaptive Immunity by Park, SaeGwang, Jiang, Zhujun, Mortenson, Eric D., Deng, Liufu, Radkevich-Brown, Olga, Yang, Xuanming, Sattar, Husain, Wang, Yang, Brown, Nicholas K., Greene, Mark, Liu, Yang, Tang, Jie, Wang, Shengdian, Fu, Yang-Xin

“…Anti-HER2/neu antibody therapy is reported to mediate tumor regression by interrupting oncogenic signals and/or inducing FcR-mediated cytotoxicity. Here, we…”
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Efficacy of Polydeoxyribonucleotide in Promoting the Healing of Diabetic Wounds in a Murine Model of Streptozotocin-Induced Diabetes: A Pilot Experiment by Yun, Jiyoung, Park, SaeGwang, Park, Ha Young, Lee, Kyung Ah

“…We assessed the efficacy of polydeoxyribonucleotide (PDRN) in accelerating the healing of diabetic wounds in a murine model of streptozotocin (STZ)-induced…”
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Thrombopoietin receptor agonist antibody for treating chemotherapy-induced thrombocytopenia by Shin, Jiwon, Kim, Min-Jung, Quan, Xingguo, Kim, Ji Woong, Lee, Sukmook, Park, SaeGwang, Jeong, Jee-Yeong, Yea, Kyungmoo

“…Thrombocytopenia is a common complication in cancer patients undergoing chemotherapy. Chemotherapy-induced thrombocytopenia (CIT) leads to dose reduction and…”
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Impact of Obesity on the IL-6 Immune Marker and Th17 Immune Cells in C57BL/6 Mice Models with Imiquimod-Induced Psoriasis by Park, So Hee, Lee, Kyung Ah, Choi, Jae-Hyeog, Park, SaeGwang, Kim, Dae-Wook, Jung, So Young

“…Obese psoriatic patients experience higher disease severity and exhibit poorer treatment responses and clinical outcomes. It has been proposed that…”
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Benzyl Isothiocyanate Attenuates Inflammasome Activation in Pseudomonas aeruginosa LPS-Stimulated THP-1 Cells and Exerts Regulation through the MAPKs/NF-κB Pathway by Park, Won Sun, Lee, Jeonghan, Na, Giyoun, Park, SaeGwang, Seo, Su-Kil, Choi, Jung Sik, Jung, Won-Kyo, Choi, Il-Whan

“…Inflammasomes are a group of intracellular multiprotein platforms that play important roles in immune systems. Benzyl isothiocyanate (BITC) is a constituent of…”
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Combined treatment with anti-HER2/neu and anti-4-1BB monoclonal antibodies induces a synergistic antitumor effect but requires dose optimization to maintain immune memory for protection from lethal rechallenge by Kim, Hee Yeon, Choi, Jae-Hyeog, Haque, Md. Masudul, Park, Jin Hee, Kim, Il-Hwan, Choi, Beom K., Lee, Anbok, Park, SaeGwang

“…Human epidermal growth factor receptor type 2 (HER2)-positive breast cancer that is treated with anti-HER2/neu monoclonal antibody (mAb) is not free from late…”
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Snail maintains metastatic potential, cancer stem-like properties, and chemoresistance in mesenchymal mouse breast cancer TUBO-P2J cells by Ma, Sun Young, Park, Jin-Hee, Jung, Hana, Ha, Sung-Min, Kim, Yeonye, Park, Dong Hyen, Lee, Deuk Hee, Lee, Sooyong, Chu, In-Ho, Jung, So Young, Kim, Il-Hwan, Choi, Il-Whan, Choi, Chang Soo, Park, Saegwang

“…Snail, a zinc-finger transcriptional repressor of E-cadherin expression, is one of the key inducers of epithelial-mesenchymal transition (EMT) in epithelial…”
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Extracellular Acidosis Promotes Metastatic Potency via Decrease of the BMAL1 Circadian Clock Gene in Breast Cancer by Kwon, Yong-Jin, Seo, Eun-Bi, Kwon, Sun-Ho, Lee, Song-Hee, Kim, Seul-Ki, Park, Sang Ki, Kim, Kyungjin, Park, SaeGwang, Park, In-Chul, Park, Jong-Wan, Ye, Sang-Kyu

“…Circadian oscillation is an essential process that influences many physiological and biological mechanisms and a decrease of circadian genes is associated with…”
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A PI3K p110α-selective inhibitor enhances the efficacy of anti-HER2/neu antibody therapy against breast cancer in mice by Choi, Jae-Hyeog, Kim, Ki Hyang, Roh, Kug-Hwan, Jung, Hana, Lee, Anbok, Lee, Ji-Young, Song, Joo Yeon, Park, Seung Jae, Kim, Ilhwan, Lee, Won-Sik, Seo, Su-Kil, Choi, Il-Whan, Fu, Yang-Xin, Yea, Sung Su, Park, SaeGwang

“…Combination therapies with phosphoinositide 3-kinase (PI3K) inhibitors and trastuzumab (anti-human epidermal growth factor receptor [HER]2/neu antibody) are…”
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Addition of Anti-neu Antibody to Local Irradiation Can Improve Tumor-Bearing BALB/c Mouse Survival through Immune-Mediated Mechanisms by Ma, Sun Young, Song, Hyunkeun, Park, Jin-Hee, Choi, Jae-Hyeog, Kim, Jin-Ho, Kim, Ki Hyang, Park, SungJae, Park, Dong Hyen, Kang, Mi Seon, Kwak, Minjung, Fu, Yang-Xin, Choi, Inhak, Cho, Heunglae, Park, SaeGwang

“…This study investigated the therapeutic effects of combined local irradiation and anti-HER2/neu antibody in a mixed tumor mouse model comprised of a…”
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Vascular Endothelial Growth Factor Receptor 1 Targeting Fusion Polypeptides with Stimuli-Responsiveness for Anti-angiogenesis by Kang, Min Jeong, Roh, Kug-Hwan, Lee, Jae Sang, Lee, Jae Hee, Park, SaeGwang, Lim, Dong Woo

“…Genetically engineered fusion polypeptides have been investigated to introduce unique bio-functionality and improve some therapeutic activity for…”
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Role of the JAK/STAT pathway in a streptozotocin-induced diabetic retinopathy mouse model by Cho, Chan-Ho, Roh, Kug-Hwan, Lim, Na-Young, Park, Sung Jae, Park, SaeGwang, Kim, Hyun Woong

“…Purpose The Janus tyrosine kinase and signal transducers and activators of transcription (JAK/STAT) pathway is involved in vascular endothelial growth factor…”
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Effective anti-neu-initiated antitumor responses require the complex role of CD4+ T cells by Mortenson, Eric D, Park, SaeGwang, Jiang, Zhujun, Wang, Shengdian, Fu, Yang-Xin

“…Targeting oncogenic receptors with antibodies has been thought to suppress tumor growth mainly by interrupting oncogenic signals. Recently, the essential role…”
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Enlightening the Immune Mechanism of the Abscopal Effect in a Murine HCC Model and Overcoming the Late Resistance With Anti-PD-L1 by Park, Jin Hee, Kim, Hee Yeon, Lee, Anbok, Seo, Young Kyeong, Kim, Il-Hwan, Park, Eun-tae, Kang, Mi Seon, Park, Sung Jae, Park, SaeGwang

“…The establishment of a preclinical model of the abscopal effect on hepatocellular carcinoma (HCC) and evaluation of whether the hypofractionated radiation…”
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Su1813 - 15-PGDH Inhibitors Promote Healing of Gastric Ulcer in Indomethacin Induced Mouse Model by Yang, Sung Yeun, Park, Jin Hee, Nam, Kyung Han, Park, SaeGwang

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15-PGDH Inhibitors Promote Healing of Gastric Ulcer in Indomethacin Induced Mouse Model by Yang, Sung Yeun, Park, Jin Hee, Nam, Kyung Han, Park, SaeGwang

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Cordyceps militaris Induces Immunogenic Cell Death and Enhances Antitumor Immunogenic Response in Breast Cancer by Park, SaeGwang, Lee, Anbok, Park, Jin Hee, Lee, Ji-Young, Kwak, Beom Seok, Quan, Xingguo, Kim, Tae Hyun

“…Cordyceps militaris has been widely used as a traditional medicine in East Asia. Its effects against breast cancer have been reported previously. However,…”
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Type I pig collagen enhances the efficacy of PEDF 34-mer peptide in a mouse model of laser-induced choroidal neovascularization by Kim, Hyun Woong, Roh, Kug-Hwan, Kim, Seong Wook, Park, Sung Jae, Lim, Na-Young, Jung, Hana, Choi, Il-Whan, Park, SaeGwang

“…Background Pigment epithelium-derived factor (PEDF)–derived 34-mer peptide (PEDF34, Asp 44 -Asn 77 ) has anti-angiogenic activity but has limitations in…”
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Effect of anthracycline and taxane on the expression of programmed cell death ligand-1 and galectin-9 in triple-negative breast cancer by Yoon, Hye Kyoung, Kim, Tae Hyun, Park, SaeGwang, Jung, Hana, Quan, Xingguo, Park, Seung Jae, Han, Jaewoong, Lee, Anbok

“…This study identified chemotherapeutic agents that up-regulate programmed cell death ligand-1 (PD-L1) and galectin-9 (Gal-9) in breast cancer cells…”
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The NADPH oxidase inhibitor DPI can abolish hypoxia-induced apoptosis of human kidney proximal tubular epithelial cells through Bcl2 up-regulation via ERK activation without ROS reduction by Song, Hyunkeun, Han, Il-Yong, Kim, Yeonye, Kim, Young Hwan, Choi, Il-Whan, Seo, Su-Kil, Jung, So Young, Park, SaeGwang, Kang, Mi Seon

“…Ischemia/reperfusion injury (IRI), resulting from hypoxic damage within a graft, is the leading cause of cell death and graft rejection. In this study, we…”
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