Search Results - "Park, Pauline K"

Immune Checkpoint Inhibition in Sepsis: A Phase 1b Randomized, Placebo-Controlled, Single Ascending Dose Study of Antiprogrammed Cell Death-Ligand 1 Antibody (BMS-936559) by Hotchkiss, Richard S., Colston, Elizabeth, Yende, Sachin, Angus, Derek C., Moldawer, Lyle L., Crouser, Elliott D., Martin, Greg S., Coopersmith, Craig M., Brakenridge, Scott, Mayr, Florian B., Park, Pauline K., Ye, June, Catlett, Ian M., Girgis, Ihab G., Grasela, Dennis M.

“…OBJECTIVES:To assess for the first time the safety and pharmacokinetics of an antiprogrammed cell death-ligand 1 immune checkpoint inhibitor (BMS-936559;…”
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Immune checkpoint inhibition in sepsis: a Phase 1b randomized study to evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamics of nivolumab by Hotchkiss, Richard S., Colston, Elizabeth, Yende, Sachin, Crouser, Elliott D., Martin, Greg S., Albertson, Timothy, Bartz, Raquel R., Brakenridge, Scott C., Delano, Matthew J., Park, Pauline K., Donnino, Michael W., Tidswell, Mark, Mayr, Florian B., Angus, Derek C., Coopersmith, Craig M., Moldawer, Lyle L., Catlett, Ian M., Girgis, Ihab G., Ye, June, Grasela, Dennis M.

“…Purpose Sepsis-associated immunosuppression increases hospital-acquired infection and viral reactivation risk. A key underlying mechanism is programmed cell…”
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Preoperative and Intraoperative Predictors of Postoperative Acute Respiratory Distress Syndrome in a General Surgical Population by BLUM, James M, STENTZ, Michael J, DECHERT, Ronald, JEWELL, Elizabeth, ENGOREN, Milo, ROSENBERG, Andrew L, PARK, Pauline K

“…Acute respiratory distress syndrome (ARDS) is a devastating condition with an estimated mortality exceeding 30%. There are data suggesting risk factors for…”
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Outcome of Adult Respiratory Failure Patients Receiving Prolonged (≥14 Days) ECMO by Posluszny, Joseph, Rycus, Peter T, Bartlett, Robert H, Engoren, Milo, Haft, Jonathan W, Lynch, William R, Park, Pauline K, Raghavendran, Krishnan, Napolitano, Lena M

“…OBJECTIVE:To examine the outcomes of prolonged (≥14 days) extracorporeal membrane oxygenation (P-ECMO) for adult severe respiratory failure and to assess…”
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Two Decades’ Experience With Interfacility Transport on Extracorporeal Membrane Oxygenation by Bryner, Benjamin, MD, Cooley, Elaine, RN, Copenhaver, William, RN, Brierley, Kristin, BS, CCRP, Teman, Nicholas, MD, Landis, Denise, RN, BSN, Rycus, Peter, MPH, Hemmila, Mark, MD, Napolitano, Lena M., MD, Haft, Jonathan, MD, Park, Pauline K., MD, Bartlett, Robert H., MD

“…Background Interfacility transport of patients on extracorporeal membrane oxygenation (ECMO) has been performed in large numbers at only a few programs…”
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Review of A Large Clinical Series: Association of Cumulative Fluid Balance on Outcome in Acute Lung Injury: A Retrospective Review of the ARDSnet Tidal Volume Study Cohort by Rosenberg, Andrew L., Dechert, Ronald E., Park, Pauline K., Bartlett, Robert H.

“…Objective: To evaluate the independent influence of fluid balance on outcomes for patients with acute lung injury. Design: Secondary analysis of a prospective…”
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Lung Injury Prediction Score in Hospitalized Patients at Risk of Acute Respiratory Distress Syndrome by Soto, Graciela J., Kor, Daryl J., Park, Pauline K., Hou, Peter C., Kaufman, David A., Kim, Mimi, Yadav, Hemang, Teman, Nicholas, Hsu, Michael C., Shvilkina, Tatyana, Grewal, Yekaterina, De Aguirre, Manuel, Gunda, Sampath, Gajic, Ognjen, Gong, Michelle Ng

“…OBJECTIVE:The Lung Injury Prediction Score identifies patients at risk for acute respiratory distress syndrome in the emergency department, but it has not been…”
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Transfusion strategies and development of acute respiratory distress syndrome in combat casualty care by Park, Pauline K, Cannon, Jeremy W, Ye, Wen, Blackbourne, Lorne H, Holcomb, John B, Beninati, William, Napolitano, Lena M

“…Damage-control resuscitation (DCR) has been advocated to reduce mortality in military and civilian settings. However, DCR and excessive crystalloid…”
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Computed Tomography Evidence of Psoas Muscle Atrophy Without Concomitant Tendon Wasting in Early Sepsis by Kubiak, Carrie A., Ranganathan, Kavitha, Matusko, Niki, Jacobson, Jon A., Wang, Stewart C., Park, Pauline K., Levi, Benjamin L.

“…Morphomic studies have demonstrated a correlation between sarcopenia and clinical outcomes in septic patients. However, tendon morphomics has not yet been…”
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Characteristics and Outcomes of Patients Hospitalized Following Pulmonary Aspiration by Lee, Augustine, MD, FCCP, Festic, Emir, MD, Park, Pauline K., MD, Raghavendran, Krishnan, MD, Dabbagh, Ousama, MD, FCCP, Adesanya, Adebola, MD, FCCP, Gajic, Ognjen, MD, FCCP, Bartz, Raquel R., MD, FCCP

“…BACKGROUND Pulmonary aspiration is an important recognized cause of ARDS. Better characterization of patients who aspirate may allow identification of…”
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Less Is More: Improved Outcomes in Surgical Patients with Conservative Fluid Administration and Central Venous Catheter Monitoring by Stewart, Ronald M., MD, FACS, Park, Pauline K., MD, FACS, Hunt, John P., MD, FACS, McIntyre, Robert C., MD, FACS, McCarthy, Janet, RN, Zarzabal, Lee Ann, MS, Michalek, Joel E., PhD

“…Background The ARDS Clinical Trials Network Fluid and Catheter Treatment Trial (FACTT) addressed fluid management and central monitoring of patients with acute…”
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Early risk factors and the role of fluid administration in developing acute respiratory distress syndrome in septic patients by Seethala, Raghu R., Hou, Peter C., Aisiku, Imoigele P., Frendl, Gyorgy, Park, Pauline K., Mikkelsen, Mark E., Chang, Steven Y., Gajic, Ognjen, Sevransky, Jonathan

“…Background Sepsis is a major risk factor for acute respiratory distress syndrome (ARDS). However, there remains a paucity of literature examining risk factors…”
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Reduction in Venous Thromboembolism Events: Trauma Performance Improvement and Loop Closure Through Participation in a State-Wide Quality Collaborative by Machado-Aranda, David A., MD, FACS, Jakubus, Jill L., PA-C, MSc, Wahl, Wendy L., MD, FACS, Cherry-Bukowiec, Jill R., MD, MSc, FACS, To, Kathleen B., MD, FACS, Park, Pauline K., MD, FACS, Raghavendran, Krishnan, MD, FACS, Napolitano, Lena M., MD, FACS, Hemmila, Mark R., MD, FACS

“…Background The Michigan Trauma Quality Improvement Program (MTQIP) is a collaborative quality initiative sponsored by Blue Cross Blue Shield of Michigan and…”
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Pharmacokinetics of Oseltamivir and Oseltamivir Carboxylate in Critically Ill Patients Receiving Continuous Venovenous Hemodialysis and/or Extracorporeal Membrane Oxygenation by Eyler, Rachel F., Heung, Michael, Pleva, Melissa, Sowinski, Kevin M., Park, Pauline K., Napolitano, Lena M., Mueller, Bruce A.

“…Study Objective To investigate oseltamivir and oseltamivir carboxylate pharmacokinetics in critically ill patients who were receiving continuous venovenous…”
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Use and Outcomes of Dexamethasone in the Management of Malignant Small Bowel Obstruction by Yang, Frank F, Serrano, Elina, Bilodeau, Kyle S, Weykamp, Michael, Silvestri, Caitlin J, Bull, Ashleigh C M, Lin, Brenda, Schaefer, Sara L, Galet, Colette, Garcia, Luis J, Gitonga, Baraka, Kolodziej, David T, Esposito, Samantha, Parker-Brigham, Molly, Luhar, Rohan, Mamgain, Avinash, Brown, Kendrick C, Dewdney, Summer, Price, Thea P, Siparsky, Nicole, Knerr, Sarah, Park, Pauline K, Sanchez, Sabrina, Skeete, Dionne A, Fischkoff, Katherine N, Flum, David R

“…To describe rates of dexamethasone use in the nonoperative management of malignant small bowel obstruction (mSBO) and their outcomes. mSBO is common in…”
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Extracorporeal Membrane Oxygenation in Adult Acute Respiratory Distress Syndrome by Park, Pauline K., MD, FCCM, Napolitano, Lena M., MD, Bartlett, Robert H., MD, FCCM

“…The role of extracorporeal membrane oxygenation (ECMO) in supporting adult refractory respiratory failure continues to evolve. Technical advances and the…”
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Modern mechanical ventilation strategies for the acute care surgeon: What you need to know by Park, Pauline K, Napolitano, Lena M

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Extracorporeal Membrane Oxygenation Support Following Stem Cell Transplant—When Is All That We Have Still Not Enough? by Park, Pauline K.

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Extracorporeal Life Support: What Should We Be Targeting? by Park, Pauline K.

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Early High-Dose Vitamin D3 for Critically Ill, Vitamin D–Deficient Patients by The National Heart, Lung, and Blood Institute PETAL Clinical Trials Network

“…This randomized, placebo-controlled trial examined the potential benefits of vitamin D 3 supplementation in acute critical illness. Among patients with proven…”
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