Acetylcholinesterase inhibition by flavonoids from Agrimonia pilosa

In a bioassay-guided search for acetylcholinesterase (AChE) inhibitors from 180 medicinal plants, an ethyl acetate extract of whole plants of Agrimonia pilosa ledeb yielded tiliroside (1), 3-methoxy quercetin (2), quercitrin (3) and quercetin (4). We report herein for the first time that all four fl...

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Bibliographic Details
Published in:	Molecules (Basel, Switzerland) Vol. 12; no. 9; pp. 2130 - 2139
Main Authors:	Jung, Mankil, Park, Moonso
Format:	Journal Article
Language:	English
Published:	Switzerland MDPI AG 03-09-2007 MDPI
Subjects:	3-methoxyquercetin Acetylcholineesterase Acetylcholinesterase - metabolism Agrimonia - chemistry Agrimonia pilosa Alzheimer's disease Animals Carbon Isotopes Cholinesterase Inhibitors - chemistry Cholinesterase Inhibitors - isolation & purification Cholinesterase Inhibitors - pharmacology Chromatography Dementia Electrophorus Flavonoids Flavonoids - chemistry Flavonoids - isolation & purification Flavonoids - pharmacology Herbal medicine Magnetic Resonance Spectroscopy Protons quercetin Spectrophotometry, Infrared tiliroside
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Summary:	In a bioassay-guided search for acetylcholinesterase (AChE) inhibitors from 180 medicinal plants, an ethyl acetate extract of whole plants of Agrimonia pilosa ledeb yielded tiliroside (1), 3-methoxy quercetin (2), quercitrin (3) and quercetin (4). We report herein for the first time that all four flavonol compounds showed significant inhibitory effects on AChE, particularly quercetin (4), which showed twice the activity of dehydroevodiamine (DHED).
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1420-3049 1420-3049
DOI:	10.3390/12092130