Search Results - "Park, Joseph K."

Systematic literature review and meta-analysis on use of Thrombopoietic agents for chemotherapy-induced thrombocytopenia by Soff, Gerald A, Ray-Coquard, Isabelle, Rivera, Luis J Marfil, Fryzek, Jon, Mullins, Megan, Bylsma, Lauren C, Park, Joseph K

“…Currently, there are no approved options to prevent or treat chemotherapy-induced thrombocytopenia (CIT). We performed a systematic literature review and…”
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Protein competition switches the function of COP9 from self-renewal to differentiation by Pan, Lei, Wang, Su, Lu, Tinglin, Weng, Changjiang, Song, Xiaoqing, Park, Joseph K., Sun, Jin, Yang, Zhi-Hao, Yu, Junjing, Tang, Hong, McKearin, Dennis M., Chamovitz, Daniel A., Ni, Jianquan, Xie, Ting

“…Using biochemical and genetic approaches, a protein-competition-based mechanism that controls the balance between stem cell self-renewal and differentiation of…”
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Bam and Bgcn antagonize Nanos-dependent germ-line stem cell maintenance by Li, Yun, Minor, Nicole T, Park, Joseph K, McKearin, Dennis M, Maines, Jean Z

“…The balance between germ-line stem cell (GSC) self-renewal and differentiation in Drosophila ovaries is mediated by the antagonistic relationship between the…”
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The miRNA Pathway Intrinsically Controls Self-Renewal of Drosophila Germline Stem Cells by Park, Joseph K., Liu, Xiang, Strauss, Tamara J., McKearin, Dennis M., Liu, Qinghua

“…Stem cells uniquely self-renew and maintain tissue homoeostasis by differentiating into different cell types to replace aged or damaged cells [1]. During…”
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Stonewalling Drosophila stem cell differentiation by epigenetic controls by Maines, Jean Z, Park, Joseph K, Williams, Meredith, McKearin, Dennis M

“…During Drosophila oogenesis, germline stem cell (GSC) identity is maintained largely by preventing the expression of factors that promote differentiation. This…”
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The incidence of thrombocytopenia in adult patients receiving chemotherapy for solid tumors or hematologic malignancies by Shaw, Jaime L., Nielson, Carrie M., Park, Joseph K., Marongiu, Andrea, Soff, Gerald A.

“…Objectives To estimate the risk of thrombocytopenia in various cancers and chemotherapy regimens. Methods Structured patient‐level data from the Flatiron…”
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Reciprocal and Nonreciprocal Recombination at the Glucocerebrosidase Gene Region: Implications for Complexity in Gaucher Disease by Tayebi, Nahid, Stubblefield, Barbara K., Park, Joseph K., Orvisky, Eduard, Walker, Jamie M., LaMarca, Mary E., Sidransky, Ellen

“…Gaucher disease results from an autosomal recessive deficiency of the lysosomal enzyme glucocerebrosidase. The glucocerebrosidase gene is located in a…”
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Myoclonic epilepsy in Gaucher disease: Genotype-phenotype insights from a rare patient subgroup by PARK, Joseph K, ORVISKY, Eduard, TAYEBI, Nahid, KANESKI, Christine, LAMARCA, Mary E, STUBBLEFIELD, Barbara K, MARTIN, Brian M, SCHIFFMANN, Raphael, SIDRANSKY, Ellen

“…Gaucher disease, the inherited deficiency of lysosomal glucocerebrosidase, presents with a wide spectrum of manifestations. Although Gaucher disease has been…”
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Assessment of romiplostim immunogenicity in adult patients in clinical trials and in a global postmarketing registry by Mytych, Daniel T., Park, Joseph K., Kim, June, Barger, Troy E., Boshier, Andy, Jawa, Vibha, Kuter, David J.

“…Summary Antibodies to first‐generation recombinant thrombopoietin (TPO) neutralized endogenous TPO and caused thrombocytopenia in some healthy subjects and…”
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A Randomized, Double-Blind, Placebo-Controlled, Phase III Noninferiority Study of the Long-Term Safety and Efficacy of Darbepoetin Alfa for Chemotherapy-Induced Anemia in Patients With Advanced NSCLC by Gascón, Pere, Nagarkar, Rajnish, Šmakal, Martin, Syrigos, Konstantinos N, Barrios, Carlos H, Sánchez, Jesús Cárdenas, Zhang, Li, Henry, David H, Gordon, David, Hirsh, Vera, Kubota, Kaoru, Orlov, Sergey, Thomas, Gary, Steinmetz, Tilman, Kang, Jin-Hyoung, Tomita, Dianne K, Fleishman, Alexander N, Park, Joseph K, De Oliveira Brandao, Cisio

“…This study evaluated noninferiority of darbepoetin alfa versus placebo for overall survival (OS) and progression-free survival (PFS) in anemic patients with…”
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Biology of the bone marrow microenvironment and myelodysplastic syndromes by Rankin, Erinn B., Narla, Anupama, Park, Joseph K., Lin, Shuo, Sakamoto, Kathleen M.

“…Myelodysplastic syndromes (MDS) are characterized by cytopenias resulting from ineffective hematopoiesis with a predisposition to transform to acute myeloid…”
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Cyclic High Negative-pressure External Volume Expansion Reduces Daily Device Application Time with Similar Effects on Recipient Site Preparation in a Murine Model by Park, Joseph K., Yeong Heo, Chan, Najmiddinov, Bakhtiyor

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Dicer-1, but not Loquacious, is critical for assembly of miRNA-induced silencing complexes by Liu, Xiang, Park, Joseph K, Jiang, Feng, Liu, Ying, McKearin, Dennis, Liu, Qinghua

“…Double-stranded RNA-binding proteins (dsRBPs), such as R2D2 and Loquacious (Loqs), function in tandem with Dicer (Dcr) enzymes in RNA interference (RNAi). In…”
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Hepatoblastoma Arising in a Pigmented β-catenin-activated Hepatocellular Adenoma: Case Report and Review of the Literature by Louie, Christine Y, Concepcion, Waldo, Park, Joseph K, Rangaswami, Arun, Finegold, Milton J, Hazard, Florette K

“…Hepatoblastoma is the most common malignant liver tumor in childhood. It has been associated with a variety of constitutional syndromes and gene mutations…”
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Phenotypic continuum in neuronopathic gaucher disease: an intermediate phenotype between type 2 and type 3 by Goker-Alpan, Ozlem, Schiffmann, Raphael, Park, Joseph K, Stubblefield, Barbara K, Tayebi, Nahid, Sidransky, Ellen

“…Neuronopathic Gaucher disease, classically divided into two types, can have a continuum of phenotypes, often defying categorization. Nine children had an…”
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Glucosylsphingosine accumulation in tissues from patients with Gaucher disease: correlation with phenotype and genotype by Orvisky, Eduard, Park, Joseph K, LaMarca, Mary E, Ginns, Edward I, Martin, Brian M, Tayebi, Nahid, Sidransky, Ellen

“…Gaucher disease, the inherited deficiency of lysosomal glucocerebrosidase, presents with a wide spectrum of clinical manifestations including neuronopathic and…”
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VELOCITY-Lung: A phase (Ph) 2 study evaluating safety and efficacy of domvanalimab (dom) + zimberelimab (zim) + sacituzumab govitecan (SG), or etrumadenant (etruma) + dom + zim, or etruma + zim in patients (pts) with treatment-naïve metastatic non-small cell lung cancer (mNSCLC) by Spira, Alexander I., Chiu, Joanne, Wang, Chin Chou, Zer, Alona, Conibear, John, Phuong, Patrick Hoang, Park, Joseph K., Seto, Anna, Zhang, Jie, Cho, Byoung Chul

“…TPS9155 Background: Current standard of care (SOC) for pts with mNSCLC lacking an actionable mutation includes checkpoint inhibitor (CPI), platinum (PT)-based…”
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Sotorasib for previously treated colorectal cancers with KRASG12C mutation (CodeBreaK100): a prespecified analysis of a single-arm, phase 2 trial by Fakih, Marwan G, Kopetz, Scott, Kuboki, Yasutoshi, Kim, Tae Won, Munster, Pamela N, Krauss, John C, Falchook, Gerald S, Han, Sae-Won, Heinemann, Volker, Muro, Kei, Strickler, John H, Hong, David S, Denlinger, Crystal S, Girotto, Gustavo, Lee, Myung-Ah, Henary, Haby, Tran, Qui, Park, Joseph K, Ngarmchamnanrith, Gataree, Prenen, Hans, Price, Timothy J

“…Sotorasib, a specific, irreversible KRASG12C protein inhibitor, has shown monotherapy clinical activity in KRASG12C-mutated solid tumours, including colorectal…”
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Sotorasib for previously treated colorectal cancers with KRAS G12C mutation (CodeBreaK100): a prespecified analysis of a single-arm, phase 2 trial by Fakih, Marwan G, Kopetz, Scott, Kuboki, Yasutoshi, Kim, Tae Won, Munster, Pamela N, Krauss, John C, Falchook, Gerald S, Han, Sae-Won, Heinemann, Volker, Muro, Kei, Strickler, John H, Hong, David S, Denlinger, Crystal S, Girotto, Gustavo, Lee, Myung-Ah, Henary, Haby, Tran, Qui, Park, Joseph K, Ngarmchamnanrith, Gataree, Prenen, Hans, Price, Timothy J

“…Sotorasib, a specific, irreversible KRAS protein inhibitor, has shown monotherapy clinical activity in KRAS -mutated solid tumours, including colorectal…”
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Analysis and Classification of 304 Mutant Alleles in Patients with Type 1 and Type 3 Gaucher Disease by Koprivica, Vuk, Stone, Deborah L, Park, Joseph K., Callahan, Megan, Frisch, Amos, Cohen, Ian J., Tayebi, Nahid, Sidransky, Ellen

“…Gaucher disease results from the inherited deficiency of the enzyme glucocerebrosidase (EC 3.2.1.45). Although >100 mutations in the gene for human…”
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