Search Results - "Park, Jinman"

Prediction of the sequence-specific cleavage activity of Cas9 variants by Kim, Nahye, Kim, Hui Kwon, Lee, Sungtae, Seo, Jung Hwa, Choi, Jae Woo, Park, Jinman, Min, Seonwoo, Yoon, Sungroh, Cho, Sung-Rae, Kim, Hyongbum Henry

“…Several Streptococcus pyogenes Cas9 (SpCas9) variants have been developed to improve an enzyme’s specificity or to alter or broaden its protospacer-adjacent…”
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Sequence-specific prediction of the efficiencies of adenine and cytosine base editors by Song, Myungjae, Kim, Hui Kwon, Lee, Sungtae, Kim, Younggwang, Seo, Sang-Yeon, Park, Jinman, Choi, Jae Woo, Jang, Hyewon, Shin, Jeong Hong, Min, Seonwoo, Quan, Zhejiu, Kim, Ji Hun, Kang, Hoon Chul, Yoon, Sungroh, Kim, Hyongbum Henry

“…Base editors, including adenine base editors (ABEs) 1 and cytosine base editors (CBEs) 2 , 3 , are widely used to induce point mutations. However, determining…”
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Korean Variant Archive (KOVA): a reference database of genetic variations in the Korean population by Lee, Sangmoon, Seo, Jihae, Park, Jinman, Nam, Jae-Yong, Choi, Ahyoung, Ignatius, Jason S., Bjornson, Robert D., Chae, Jong-Hee, Jang, In-Jin, Lee, Sanghyuk, Park, Woong-Yang, Baek, Daehyun, Choi, Murim

“…Despite efforts to interrogate human genome variation through large-scale databases, systematic preference toward populations of Caucasian descendants has…”
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High-throughput analysis of the activities of xCas9, SpCas9-NG and SpCas9 at matched and mismatched target sequences in human cells by Kim, Hui Kwon, Lee, Sungtae, Kim, Younggwang, Park, Jinman, Min, Seonwoo, Choi, Jae Woo, Huang, Tony P., Yoon, Sungroh, Liu, David R., Kim, Hyongbum Henry

“…The applications of clustered regularly interspaced short palindromic repeats (CRISPR)-based genome editing can be limited by a lack of compatible protospacer…”
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Predicting the efficiency of prime editing guide RNAs in human cells by Kim, Hui Kwon, Yu, Goosang, Park, Jinman, Min, Seonwoo, Lee, Sungtae, Yoon, Sungroh, Kim, Hyongbum Henry

“…Prime editing enables the introduction of virtually any small-sized genetic change without requiring donor DNA or double-strand breaks. However, evaluation of…”
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Prediction of Base Editing Efficiencies and Outcomes Using DeepABE and DeepCBE by Park, Jinman, Kim, Hui Kwon

“…Adenine base editors (ABEs) and cytosine base editors (CBEs) have been widely used to introduce disease-relevant point mutations at target DNA sites of…”
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Is the Chinese Government's Increase in Development Co-operation with Africa the Revival of Sinocentrism? by Park, Jinman

“…Over the past few decades, the rapid growth of China's development co-operation with Africa has attracted worldwide attention. Some people assert that…”
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Prediction of efficiencies for diverse prime editing systems in multiple cell types by Yu, Goosang, Kim, Hui Kwon, Park, Jinman, Kwak, Hyunjong, Cheong, Yumin, Kim, Dongyoung, Kim, Jiyun, Kim, Jisung, Kim, Hyongbum Henry

“…Applications of prime editing are often limited due to insufficient efficiencies, and it can require substantial time and resources to determine the most…”
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SynDesign: web-based prime editing guide RNA design and evaluation tool for saturation genome editing by Park, Jinman, Yu, Goosang, Seo, Sang-Yeon, Yang, Jinyeong, Kim, Hyongbum Henry

“…Saturation genome editing (SGE) enables in-depth functional evaluation of disease-associated genes and variants by generating all possible single nucleotide…”
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Author Correction: Predicting the efficiency of prime editing guide RNAs in human cells by Kim, Hui Kwon, Yu, Goosang, Park, Jinman, Min, Seonwoo, Lee, Sungtae, Yoon, Sungroh, Kim, Hyongbum Henry

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High-throughput functional evaluation of human cancer-associated mutations using base editors by Kim, Younggwang, Lee, Seungho, Cho, Soohyuk, Park, Jinman, Chae, Dongwoo, Park, Taeyoung, Minna, John D., Kim, Hyongbum Henry

“…Comprehensive phenotypic characterization of the many mutations found in cancer tissues is one of the biggest challenges in cancer genomics. In this study, we…”
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Deep learning models to predict the editing efficiencies and outcomes of diverse base editors by Kim, Nahye, Choi, Sungchul, Kim, Sungjae, Song, Myungjae, Seo, Jung Hwa, Min, Seonwoo, Park, Jinman, Cho, Sung-Rae, Kim, Hyongbum Henry

“…Applications of base editing are frequently restricted by the requirement for a protospacer adjacent motif (PAM), and selecting the optimal base editor (BE)…”
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General rules for functional microRNA targeting by Kim, Doyeon, Sung, You Me, Park, Jinman, Kim, Sukjun, Kim, Jongkyu, Park, Junhee, Ha, Haeok, Bae, Jung Yoon, Kim, SoHui, Baek, Daehyun

“…Daehyun Baek and colleagues present a systematic analysis of more than 2 billion potential miRNA–gene target interactions using publicly available human…”
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SpCas9 activity prediction by DeepSpCas9, a deep learning-based model with high generalization performance by Kim, Hui Kwon, Kim, Younggwang, Lee, Sungtae, Min, Seonwoo, Bae, Jung Yoon, Choi, Jae Woo, Park, Jinman, Jung, Dongmin, Yoon, Sungroh, Kim, Hyongbum Henry

“…We evaluated SpCas9 activities at 12,832 target sequences using a high-throughput approach based on a human cell library containing single-guide RNA-encoding…”
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Recording of elapsed time and temporal information about biological events using Cas9 by Park, Jihye, Lim, Jung Min, Jung, Inkyung, Heo, Seok-Jae, Park, Jinman, Chang, Yoojin, Kim, Hui Kwon, Jung, Dongmin, Yu, Ji Hea, Min, Seonwoo, Yoon, Sungroh, Cho, Sung-Rae, Park, Taeyoung, Kim, Hyongbum Henry

“…DNA has not been utilized to record temporal information, although DNA has been used to record biological information and to compute mathematical problems…”
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Massively parallel evaluation and computational prediction of the activities and specificities of 17 small Cas9s by Seo, Sang-Yeon, Min, Seonwoo, Lee, Sungtae, Seo, Jung Hwa, Park, Jinman, Kim, Hui Kwon, Song, Myungjae, Baek, Dawoon, Cho, Sung-Rae, Kim, Hyongbum Henry

“…Recently, various small Cas9 orthologs and variants have been reported for use in in vivo delivery applications. Although small Cas9s are particularly suited…”
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MMSeaIce: a collection of techniques for improving sea ice mapping with a multi-task model by Chen, Xinwei, Patel, Muhammed, Pena Cantu, Fernando J, Park, Jinman, Noa Turnes, Javier, Xu, Linlin, Scott, K. Andrea, Clausi, David A

“…The AutoICE challenge, organized by multiple national and international agencies, seeks to advance the development of near-real-time sea ice products with…”
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Fourier-based shape feature extraction technique for computer-aided B-Mode ultrasound diagnosis of breast tumor by Lee, Jong-Ha, Seong, Yeong Kyeong, Chang, Chu-Ho, Park, Jinman, Park, Moonho, Woo, Kyoung-Gu, Ko, Eun Young

“…Early detection of breast tumor is critical in determining the best possible treatment approach. Due to its superiority compared with mammography in its…”
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The Influence of Input Variable Selection on Deep Learning-Based Sea Ice Parameter Inversion from Multi-Sensor Satellite Data by Chen, Xinwei, Patel, Muhammed, Cantu, Fernando J. Pena, Park, Jinman, Turnes, Javier Noa, Jiang, Mingzhe, Xu, Linlin, Scott, K. Andrea, Clausi, David A., Huang, Weimin

“…The automated mapping of Arctic sea ice using satellite data from various sources plays a critical role in maritime shipping and climate science research. Deep…”
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A Hierarchical Multitask U-Net for Automated Sea Ice Mapping from AI4Arctic Sea Ice Challenge Dataset by Pena Cantu, Fernando J., Chen, Xinwei, Liu, Yizhe, Kanani, Kirtan, Park, Jinman, Tunes, Javier Noa, Xu, Linlin, Scott, K. Andrea, Clausi, David A.

“…Sea ice monitoring is a vital task for various applications, such as climate research, ship navigation, and Arctic sea route planning. However, manual…”
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