Search Results - "Park, Eun Hae"
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Caenorhabditis elegans Lipin 1 moderates the lifespan‐shortening effects of dietary glucose by maintaining ω‐6 polyunsaturated fatty acids
Published in Aging cell (01-06-2020)“…Excessive glucose causes various diseases and decreases lifespan by altering metabolic processes, but underlying mechanisms remain incompletely understood…”
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Diacetyl odor shortens longevity conferred by food deprivation in C. elegans via downregulation of DAF‐16/FOXO
Published in Aging cell (01-01-2021)“…Dietary restriction extends lifespan in various organisms by reducing the levels of both nutrients and non‐nutritional food‐derived cues. However, the identity…”
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A PTEN variant uncouples longevity from impaired fitness in Caenorhabditis elegans with reduced insulin/IGF-1 signaling
Published in Nature communications (24-09-2021)“…Insulin/IGF-1 signaling (IIS) regulates various physiological aspects in numerous species. In Caenorhabditis elegans , mutations in the daf-2 /insulin/IGF-1…”
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Reduced insulin/IGF1 signaling prevents immune aging via ZIP-10/bZIP-mediated feedforward loop
Published in The Journal of cell biology (03-05-2021)“…A hallmark of aging is immunosenescence, a decline in immune functions, which appeared to be inevitable in living organisms, including Caenorhabditis elegans…”
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Inhibition of the oligosaccharyl transferase in Caenorhabditis elegans that compromises ER proteostasis suppresses p38-dependent protection against pathogenic bacteria
Published in PLoS genetics (04-03-2020)“…The oligosaccharyl transferase (OST) protein complex mediates the N-linked glycosylation of substrate proteins in the endoplasmic reticulum (ER), which…”
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Mitochondrial aconitase suppresses immunity by modulating oxaloacetate and the mitochondrial unfolded protein response
Published in Nature communications (22-06-2023)“…Accumulating evidence indicates that mitochondria play crucial roles in immunity. However, the role of the mitochondrial Krebs cycle in immunity remains…”
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Analysis on the Effectiveness and Characteristics of Treatment Modalities for Bowen's Disease: An Observational Study
Published in Journal of clinical medicine (12-05-2022)“…Treatment options for Bowen's disease (BD) include surgical excision, cryotherapy, curettage with cautery, topical 5-fluorouracil or imiquimod, and…”
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VRK-1 extends life span by activation of AMPK via phosphorylation
Published in Science advances (01-07-2020)“…Vaccinia virus-related kinase (VRK) is an evolutionarily conserved nuclear protein kinase. VRK-1, the single VRK ortholog, functions in cell division and…”
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Survival assays using Caenorhabditis elegans
Published in Molecules and cells (01-02-2017)Get full text
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Caenorhabditis elegans algn-2 Is Critical for Longevity Conferred by Enhanced Nonsense-Mediated mRNA Decay
Published in iScience (20-11-2020)“…Nonsense-mediated mRNA decay (NMD) is a biological surveillance mechanism that eliminates mRNA transcripts with premature termination codons. In Caenorhabditis…”
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Survival assays using Caenorhabditis elegans
Published in Molecules and cells (01-02-2017)“…is an important model organism with many useful features, including rapid development and aging, easy cultivation, and genetic tractability. Survival assays…”
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Social media and disasters: a functional framework for social media use in disaster planning, response, and research
Published in Disasters (01-01-2015)“…A comprehensive review of online, official, and scientific literature was carried out in 2012–13 to develop a framework of disaster social media. This…”
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Systematic transcriptome analysis associated with physiological and chronological aging in Caenorhabditis elegans
Published in Genome research (01-11-2022)“…Aging is associated with changes in a variety of biological processes at the transcriptomic level, including gene expression. Two types of aging occur during a…”
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Prediction of Axillary Lymph Node Metastasis in Early Breast Cancer Using Dynamic Contrast-Enhanced Magnetic Resonance Imaging and Diffusion-Weighted Imaging
Published in Investigative magnetic resonance imaging (2019)“…Purpose: The purpose of this study was to evaluate dynamic contrast-enhanced breast magnetic resonance imaging (DCE-MRI), and diffusion-weighted imaging (DWI)…”
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Look who is warning: individual differences in motivation activation influence behaviors during disasters
Published in Journal of risk research (03-03-2020)“…This study investigated individual differences in responses to disasters based on participants' motivational reactivity and ethical ideology. Motivational…”
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Can Bone Erosion in Axial Spondyloarthropathy be Detected by Ultrashort Echo Time Imaging? A Comparison With Computed Tomography in the Sacroiliac Joint
Published in Journal of magnetic resonance imaging (01-11-2022)“…Background Structural lesion evaluation in axial spondyloarthropathy (SpA) can improve accuracy of diagnosis. However, structural lesions (bone erosions) are…”
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Early detection of ankylosing spondylitis using texture features and statistical machine learning, and deep learning, with some patient age analysis
Published in Computerized medical imaging and graphics (01-06-2020)“…•3 Classifiers trained to diagnose erosion (early ankylosing spondylitis sign) from CT.•Random forest with texture features achieved 96% accuracy, 93% recall,…”
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The role of RNA helicases in aging and lifespan regulation
Published in Translational medicine of aging (01-10-2017)“…RNA helicases are members of a large family of enzymes that function in unwinding RNA duplexes and modulating interactions between RNAs and proteins. RNA…”
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HLH-30/TFEB mediates sexual dimorphism in immunity in caenorhabditis elegans
Published in Autophagy (20-07-2024)“…Sexual dimorphism affects various biological functions, including immune responses. However, the mechanisms by which sex alters immunity remain largely…”
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Changes in metabolic syndrome and risk of psoriasis: a nationwide population-based study
Published in Scientific reports (15-12-2021)“…Metabolic syndrome (MetS) is associated with psoriasis, but it remains unclear whether risk of psoriasis remains in patients whose MetS diagnosis changes. To…”
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