Search Results - "Park, Chin"

Biophysical investigation of the dual binding surfaces of human transcription factors FOXO4 and p53 by Kim, Jinwoo, Ahn, Dabin, Park, Chin‐Ju

“…Cellular senescence is protective against external oncogenic stress, but its accumulation causes aging‐related diseases. Forkhead box O4 (FOXO4) and p53 are…”
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Protective roles of highly conserved motif 1 in tardigrade cytosolic‐abundant heat soluble protein in extreme environments by Kang, Donguk, Yang, Min June, Kim, Hwan, Park, Chin‐Ju

“…Tardigrades are remarkable microscopic animals that survive harsh conditions such as desiccation and extreme temperatures. Tardigrade‐specific intrinsically…”
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FOXO4 Transactivation Domain Interaction with Forkhead DNA Binding Domain and Effect on Selective DNA Recognition for Transcription Initiation by Kim, Jinwoo, Ahn, Dabin, Park, Chin-Ju

“…[Display omitted] •FOXO4 is the human transcription factor that is crucial for cell homeostasis.•Trasactivation domain (TAD) interaction with forkhead DNA…”
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Determinants of replication protein A subunit interactions revealed using a phosphomimetic peptide by Lee, Sungjin, Heo, Jeongbeen, Park, Chin-Ju

“…Replication protein A (RPA) is a eukaryotic ssDNA-binding protein and contains three subunits: RPA70, RPA32, and RPA14. Phosphorylation of the N-terminal…”
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Development of Replication Protein A‑Conjugated Gold Nanoparticles for Highly Sensitive Detection of Disease Biomarkers by Kang, Juyoung, Yeom, Gyuho, Jang, Hyungjun, Oh, Jusung, Park, Chin-Ju, Kim, Min-Gon

“…Paper-based lateral flow immunoassays (LFIAs) using conventional sandwich-type immunoassays are one of the most commonly used point-of-care (PoC) tests…”
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Controlling the Chameleonic Behavior and Membrane Permeability of Cyclosporine Derivatives via Backbone and Side Chain Modifications by Lee, Dongjae, Choi, Jieun, Yang, Min June, Park, Chin-Ju, Seo, Jiwon

“…Some macrocycles exhibit enhanced membrane permeability through conformational switching in different environmental polarities, a trait known as chameleonic…”
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Molecular Diagnostic System Using Engineered Fusion Protein-Conjugated Magnetic Nanoparticles by Kang, Juyoung, Kang, Donguk, Yeom, Gyuho, Park, Chin-Ju

“…To effectively control the spread of new infectious diseases, there is a need for highly sensitive diagnostic methods to detect viral nucleic acids rapidly…”
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Investigation of the core binding regions of human Werner syndrome and Fanconi anemia group J helicases on replication protein A by Yeom, Gyuho, Kim, Jinwoo, Park, Chin-Ju

“…Werner syndrome protein (WRN) and Fanconi anemia group J protein (FANCJ) are human DNA helicases that contribute to genome maintenance. They interact with…”
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Loop-mediated fluorescent probes for selective discrimination of parallel and antiparallel G-Quadruplexes by Pandith, Anup, Nagarajachari, Upendra, Siddappa, Ravi Kumara Guralamatta, Lee, Sungjin, Park, Chin–Ju, Sannathammegowda, Krishnaveni, Seo, Young Jun

“…[Display omitted] •Probe 1, selectively discriminated parallel G4s from anti-parallel/hybrid G4s.•The disaggregation of probe 1 was very effective in the…”
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Dynamics Studies of DNA with Non-canonical Structure Using NMR Spectroscopy by Oh, Kwang-Im, Kim, Jinwoo, Park, Chin-Ju, Lee, Joon-Hwa

“…The non-canonical structures of nucleic acids are essential for their diverse functions during various biological processes. These non-canonical structures can…”
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NMR Structure and Biophysical Characterization of Thermophilic Single-Stranded DNA Binding Protein from Sulfolobus Solfataricus by Yang, Min June, Kim, Jinwoo, Lee, Yeongjoon, Lee, Woonghee, Park, Chin-Ju

“…Proteins from , an extremophile, are active even at high temperatures. The single-stranded DNA (ssDNA) binding protein of (SsoSSB) is overexpressed to protect…”
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Highly sensitive and universal detection strategy based on a colorimetric assay using target-specific heterogeneous sandwich DNA aptamer by Kang, Juyoung, Yeom, Gyuho, Jang, Hyungjun, Park, Chin-Ju, Kim, Min-Gon

“…A simple, universal, and sensitive colorimetric biosensor for detecting of various biomarkers was devised using a target-specific DNA aptamer, as the…”
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Interplay among Conformation, Intramolecular Hydrogen Bonds, and Chameleonicity in the Membrane Permeability and Cyclophilin A Binding of Macrocyclic Peptide Cyclosporin O Derivatives by Lee, Dongjae, Lee, Sungjin, Choi, Jieun, Song, Yoo-Kyung, Kim, Min Ju, Shin, Dae-Seop, Bae, Myung Ae, Kim, Yong-Chul, Park, Chin-Ju, Lee, Kyeong-Ryoon, Choi, Jun-Ho, Seo, Jiwon

“…A macrocyclic peptide scaffold with well-established structure–property relationship is desirable for tackling undruggable targets. Here, we adopted a natural…”
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Interaction of replication protein A with two acidic peptides from human Bloom syndrome protein by Kang, Donguk, Lee, Sungjin, Ryu, Kyoung‐Seok, Cheong, Hae‐Kap, Kim, Eun‐Hee, Park, Chin‐Ju

“…Bloom syndrome protein (BLM) is one of five human RecQ helicases which maintain genomic stability. Interaction of BLM with replication protein A (RPA)…”
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Development of DNA Aptamers against the Nucleocapsid Protein of Severe Fever with Thrombocytopenia Syndrome Virus for Diagnostic Application: Catalytic Signal Amplification using Replication Protein A‑Conjugated Liposomes by Yeom, Gyuho, Kang, Juyoung, Jang, Hyungjun, Nam, Ho Yeon, Kim, Min-Gon, Park, Chin-Ju

“…Most prevalent infectious diseases worldwide are caused by mediators such as insects and characterized by high mortality and morbidity, thereby creating a…”
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AC-motif: a DNA motif containing adenine and cytosine repeat plays a role in gene regulation by Hur, Jeong Hwan, Kang, Chan Young, Lee, Sungjin, Parveen, Nazia, Yu, Jihyeon, Shamim, Amen, Yoo, Wanki, Ghosh, Ambarnil, Bae, Sangsu, Park, Chin-Ju, Kim, Kyeong Kyu

“…Abstract I-motif or C4 is a four-stranded DNA structure with a protonated cytosine:cytosine base pair (C+:C) found in cytosine-rich sequences. We have found…”
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Backbone Dynamics and Model‐Free Analysis of the RecQ C‐Terminal Domain of Bloom Syndrome Protein by Yoo, Sooji, Lee, Sungjin, Park, Chin‐Ju

“…Bloom syndrome protein (BLM) is one of RecQ helicases, which are conserved DNA unwinding enzymes in DNA metabolisms. The RecQ C‐terminal domain (RQC) of BLM is…”
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NMR Investigation of the Interaction between the RecQ C-Terminal Domain of Human Bloom Syndrome Protein and G-Quadruplex DNA from the Human c-Myc Promoter by Lee, Sungjin, Lee, Ae-Ree, Ryu, Kyoung-Seok, Lee, Joon-Hwa, Park, Chin-Ju

“…Bloom syndrome protein (BLM) is one of five human RecQ helicases that participate in DNA metabolism. RecQ C-terminal (RQC) domain is the main DNA binding…”
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Resonance assignments and secondary structure of thermophile single‐stranded DNA binding protein from Sulfolobus solfataricus at 323K by Yang, Min June, Lee, Woonghee, Park, Chin-Ju

“…Single-stranded DNA (ssDNA)-binding proteins (SSBs) are essential for DNA replication, recombination, and repair processes in all organisms. Sulfolobus…”
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Structural basis for the inhibition of PDK2 by novel ATP- and lipoyl-binding site targeting compounds by Kang, Jihoon, Pagire, Haushabhau S., Kang, Donguk, Song, Yo Han, Lee, In Kyu, Lee, Kang Taek, Park, Chin-Ju, Ahn, Jin Hee, Kim, Jungwook

“…Pyruvate dehydrogenase kinase (PDK) controls the activity of pyruvate decarboxylase complex (PDC) by phosphorylating key serine residues on the E1 subunit,…”
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