Search Results - "Park, Chi‐Hyun"

Carnitine acetyltransferase deficiency mediates mitochondrial dysfunction‐induced cellular senescence in dermal fibroblasts by Song, Min Ji, Park, Chi‐Hyun, Kim, Haesoo, Han, Sangbum, Lee, Si Hyung, Lee, Dong Hun, Chung, Jin Ho

“…Aging is accompanied by impaired mitochondrial function and accumulation of senescent cells. Mitochondrial dysfunction contributes to senescence by increasing…”
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Gasdermin C is induced by ultraviolet light and contributes to MMP-1 expression via activation of ERK and JNK pathways by Kusumaningrum, Novi, Lee, Dong Hun, Yoon, Hyun-Sun, Kim, Yeon Kyung, Park, Chi-Hyun, Chung, Jin Ho

“…•Expression of GSDMC is increased by UV irradiation in human skin keratinocytes.•Increase of GSDMC by UV contributes to the expression of MMP-1 and the…”
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A synthetic peptide blocking TRPV1 activation inhibits UV-induced skin responses by Kang, So Min, Han, Sangbum, Oh, Jang-Hee, Lee, Young Mee, Park, Chi-Hyun, Shin, Chang-Yup, Lee, Dong Hun, Chung, Jin Ho

“…Highlights • TRPV1 inhibitory peptide (TIP) which mimics the specific site in TRPV1 was devised. • TIP inhibited UV-induced MMP-1, IL-6, and TNF-α in HaCaT in…”
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A natural compound harmine decreases melanin synthesis through regulation of the DYRK1A/NFATC3 pathway by Park, Chi-Hyun, Kim, Goeun, Lee, Yuri, Kim, Haesoo, Song, Min Ji, Lee, Dong Hun, Chung, Jin Ho

“…•A natural compound harmine decreased melanin synthesis and tyrosinase expression in human MNT-1 melanoma cells and human primary melanocytes.•Melanin…”
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Ultraviolet light-induced gasdermin C expression is mediated via TRPV1/calcium/calcineurin/NFATc1 signaling by Kusumaningrum, Novi, Lee, Dong Hun, Yoon, Hyun-Sun, Park, Chi-Hyun, Chung, Jin Ho

“…Gasdermin (GSDM)‑C is a member of the GSDM gene family and is expressed in the epithelial cells of various tissue types, including skin. GSDMC expression is…”
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Ultraviolet irradiation-induced inhibition of histone deacetylase 4 increases the expression of matrix metalloproteinase-1 but decreases that of type I procollagen via activating JNK in human dermal fibroblasts by Lee, Yuri, Shin, Mi Hee, Kim, Min-Kyoung, Park, Chi-Hyun, Shin, Hye Sun, Lee, Dong Hun, Chung, Jin Ho

“…•Ultraviolet (UV) irradiation is the main contributing factor for skin aging.•UV treatment decreases the expression of HDACs and SIRTs in dermal…”
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Toll-like receptor family members in skin fibroblasts are functional and have a higher expression compared to skin keratinocytes by YAO, CHENG, OH, JANG-HEE, LEE, DONG HUN, BAE, JUNG-SOO, JIN, CHENG LONG, PARK, CHI-HYUN, CHUNG, JIN HO

“…Toll-like receptors (TLRs) are known to recognize not only pathogen-associated molecular patterns but also danger-associated molecular patterns. Recent studies…”
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Effects of infrared radiation and heat on human skin aging in vivo by Cho, Soyun, Shin, Mi Hee, Kim, Yeon Kyung, Seo, Jo-Eun, Lee, Young Mee, Park, Chi-Hyun, Chung, Jin Ho

“…Sunlight damages human skin, resulting in a wrinkled appearance. Since natural sunlight is polychromatic, its ultimate effects on the human skin are the result…”
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UV Modulation of Subcutaneous Fat Metabolism by Kim, Eun Ju, Kim, Yeon Kyung, Kim, Ji Eun, Kim, Sojeong, Kim, Min-Kyoung, Park, Chi-Hyun, Chung, Jin Ho

“…Adipose tissue is not a homogeneous organ. Visceral fat accumulation is associated with atherosclerosis and metabolic syndrome, but peripheral subcutaneous…”
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Transient Receptor Potential Vanilloid-1 Mediates Heat-Shock-Induced Matrix Metalloproteinase-1 Expression in Human Epidermal Keratinocytes by Li, Wen H., Lee, Young M., Kim, Jee Y., Kang, Seokwon, Kim, Sangmin, Kim, Kyu H., Park, Chi-Hyun, Chung, Jin H.

“…Transient receptor potential vanilloid-1 (TRPV1), a heat-gated channel, was recently found on human keratinocytes and the activation of epidermal TRPV1 was…”
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Epidermal growth factor-induced matrix metalloproteinase-1 expression is negatively regulated by p38 MAPK in human skin fibroblasts by Park, Chi-Hyun, Chung, Jin Ho

“…Abstract Background Many extracellular stimuli, including epidermal growth factor (EGF), are known to induce MMP-1 expression. Recently, several reports have…”
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UV decreases the synthesis of free fatty acids and triglycerides in the epidermis of human skin in vivo, contributing to development of skin photoaging by Kim, Eun Ju, Jin, Xing-Ji, Kim, Yeon Kyung, Oh, In Kyung, Kim, Ji Eun, Park, Chi-Hyun, Chung, Jin Ho

“…Abstract Background Although fatty acids are known to be important in various skin functions, their roles on photoaging in human skin are poorly understood…”
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Heat Shock-Induced Matrix Metalloproteinase (MMP)-1 and MMP-3 Are Mediated through ERK and JNK Activation and via an Autocrine Interleukin-6 Loop by Park, Chi-Hyun, Lee, Min Jung, Ahn, Jungmi, Kim, Sangmin, Kim, Hyeon Ho, Kim, Kyu Han, Eun, Hee Chul, Chung, Jin Ho

“…Although many studies have been performed to elucidate the molecular consequences of ultraviolet irradiation, little is known about the effect of infrared…”
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Galanin contributes to ultraviolet irradiation‐induced inflammation in human skin by Lee, Min Jung, Oh, Jang‐Hee, Park, Chi‐Hyun, Kim, Kyu Han, Lee, Dong Hun, Chung, Jin Ho

“…Exposure of the skin to ultraviolet (UV) irradiation causes various consequences such as inflammation and photoageing. Galanin is an active neuropeptide…”
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H2O2 Accumulation by Catalase Reduction Changes MAP Kinase Signaling in Aged Human Skin In Vivo by Shin, Mi Hee, Rhie, Gi-eun, Kim, Yeon Kyung, Park, Chi-Hyun, Cho, Kwang Hyun, Kim, Kyu Han, Eun, Hee Chul, Chung, Jin Ho

“…To understand the molecular alterations occurring during the aging process, we compared mitogen-activated protein (MAP) kinase activities in the intrinsically…”
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Toll-like receptor 3 mediates UVB-induced MMP-13 and MMP-3 expressions in mice by Yao, Cheng, Han, Sangbum, Tian, Yu-Dan, Shin, Chang-yup, Park, Chi-Hyun, Kim, Ye-Ji, Lee, Dong Hun, Chung, Jin Ho

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Serum amyloid A1 secreted from UV-irradiated keratinocytes induces matrix metalloproteinase-1 in fibroblasts through toll-like receptor 4 by Han, Sangbum, Jin, Seon-Pil, Oh, Jang-Hee, Seo, Eun-Young, Park, Chi-Hyun, Yoon, Hyun-Sun, Lee, Dong Hun, Chung, Jin Ho

“…Ultraviolet (UV) irradiation on skin triggers photoageing‐related phenotypes such as formation of wrinkles. UV ray upregulates matrix metalloproteinase‐1…”
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Poly(I:C) induces expressions of MMP-1, -2, and -3 through various signaling pathways including IRF3 in human skin fibroblasts by Yao, Cheng, Lee, Dong Hun, Oh, Jang-Hee, Kim, Min-Kyoung, Kim, Kyu Han, Park, Chi-Hyun, Chung, Jin Ho

“…Highlights • Poly(I:C) treatment induces expressions of MMP-1, -2, and -3. • Poly(I:C) induces MMP-1, -2, and -3 expressions via different signaling pathways…”
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UV irradiation-induced production of monoglycosylated biglycan through downregulation of xylosyltransferase 1 in cultured human dermal fibroblasts by Jin, Cheng Long, Oh, Jang-Hee, Han, Mira, Shin, Min Kyeong, Yao, Cheng, Park, Chi-Hyun, Jin, Zhe Hu, Chung, Jin Ho

“…Highlights • UV increases monoglycosylated biglycan production in cultured fibroblasts. • UV decreases XYLT1 mRNA expression much more than XYLT2. • Only XYLT1…”
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Eicosapentaenoic acid inhibits UV-induced MMP-1 expression in human dermal fibroblasts by Kim, Hyeon Ho, Shin, Chung Min, Park, Chi-Hyun, Kim, Kyu Han, Cho, Kwang Hyun, Eun, Hee Chul, Chung, Jin Ho

“…Ultraviolet (UV) irradiation regulates UV-responsive genes, including matrix metalloproteinases (MMPs). Moreover, UV-induced MMPs cause connective tissue…”
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