Search Results - "Parish, A."

The Transcription Factor FoxO1 Sustains Expression of the Inhibitory Receptor PD-1 and Survival of Antiviral CD8+ T Cells during Chronic Infection by Staron, Matthew M., Gray, Simon M., Marshall, Heather D., Parish, Ian A., Chen, Jonathan H., Perry, Curtis J., Cui, Guoliang, Li, Ming O., Kaech, Susan M.

“…Protein kinase B (also known as AKT) and the mechanistic target of rapamycin (mTOR) are central regulators of T cell differentiation, proliferation,…”
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CRISPR/Cas9 mediated deletion of the adenosine A2A receptor enhances CAR T cell efficacy by Giuffrida, Lauren, Sek, Kevin, Henderson, Melissa A., Lai, Junyun, Chen, Amanda X. Y., Meyran, Deborah, Todd, Kirsten L., Petley, Emma V., Mardiana, Sherly, Mølck, Christina, Stewart, Gregory D., Solomon, Benjamin J., Parish, Ian A., Neeson, Paul J., Harrison, Simon J., Kats, Lev M., House, Imran G., Darcy, Phillip K., Beavis, Paul A.

“…Adenosine is an immunosuppressive factor that limits anti-tumor immunity through the suppression of multiple immune subsets including T cells via activation of…”
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Differential Expression of Ly6C and T-bet Distinguish Effector and Memory Th1 CD4 + Cell Properties during Viral Infection by Marshall, Heather D., Chandele, Anmol, Jung, Yong Woo, Meng, Hailong, Poholek, Amanda C., Parish, Ian A., Rutishauser, Rachel, Cui, Weiguo, Kleinstein, Steven H., Craft, Joe, Kaech, Susan M.

“…CD4 + T cells differentiate into multiple effector types, but it is unclear how they form memory T cells during infection in vivo. Profiling virus-specific CD4…”
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Protecting group free radical C-H trifluoromethylation of peptides by Ichiishi, Naoko, Caldwell, John P, Lin, Melissa, Zhong, Wendy, Zhu, Xiaohong, Streckfuss, Eric, Kim, Hai-Young, Parish, Craig A, Krska, Shane W

“…Two radical-based approaches have been developed to effect the trifluoromethylation of aryl C-H bonds in native peptides either using stoichiometric oxidant or…”
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Modelling the Anatomic Distribution of Neurologic Events in Patients with COVID-19: A Systematic Review of MRI Findings by Parsons, N, Outsikas, A, Parish, A, Clohesy, R, D'Aprano, F, Toomey, F, Advani, S, Poudel, G R

“…Neurologic events have been reported in patients with coronavirus disease 2019 (COVID-19). However, a model-based evaluation of the spatial distribution of…”
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Prostaglandin E2 and programmed cell death 1 signaling coordinately impair CTL function and survival during chronic viral infection by Chen, Jonathan H, Perry, Curtis J, Tsui, Yao-Chen, Staron, Matthew M, Parish, Ian A, Dominguez, Claudia X, Rosenberg, Daniel W, Kaech, Susan M

“…Susan Kaech and colleagues report that in chronic viral infection, prostaglandin E2 and PD-1 signaling suppressed the function and survival of cytotoxic T…”
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Revisiting T Cell Tolerance as a Checkpoint Target for Cancer Immunotherapy by Nüssing, Simone, Trapani, Joseph A, Parish, Ian A

“…Immunotherapy has revolutionized the treatment of cancer. Nevertheless, the majority of patients do not respond to therapy, meaning a deeper understanding of…”
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Natural killer cell activation enhances immune pathology and promotes chronic infection by limiting CD8+ T-cell immunity by Lang, Philipp A, Lang, Karl S, Xu, Haifeng C, Grusdat, Melanie, Parish, Ian A, Recher, Mike, Elford, Alisha R, Dhanji, Salim, Shaabani, Namir, Tran, Charles W, Dissanayake, Dilan, Rahbar, Ramtin, Ghazarian, Magar, Brüstle, Anne, Fine, Jason, Chen, Peter, Weaver, Casey T, Klose, Christoph, Diefenbach, Andreas, Häussinger, Dieter, Carlyle, James R, Kaech, Susan M, Mak, Tak W, Ohashi, Pamela S

“…Infections with HIV, hepatitis B virus, and hepatitis C virus can turn into chronic infections, which currently affect more than 500 million patients…”
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A Critical Role of IL-21-Induced BATF in Sustaining CD8-T-Cell-Mediated Chronic Viral Control by Xin, Gang, Schauder, David M., Lainez, Begoña, Weinstein, Jason S., Dai, Zhengxi, Chen, Yuhong, Esplugues, Enric, Wen, Renren, Wang, Demin, Parish, Ian A., Zajac, Allan J., Craft, Joe, Cui, Weiguo

“…Control of chronic viral infections by CD8 T cells is critically dependent on CD4 help. In particular, helper-derived IL-21 plays a key role in sustaining the…”
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Characterization of RNA driven structural changes in full length RIG-I leading to its agonism or antagonism by Sikorska, Justyna, Hou, Yan, Chiurazzi, Paul, Siu, Tony, Baltus, Gretchen A, Sheth, Payal, McLaren, David G, Truong, Quang, Parish, Craig A, Wyss, Daniel F

“…Abstract RIG-I (retinoic acid inducible gene-I) can sense subtle differences between endogenous and viral RNA in the cytoplasm, triggering an anti-viral immune…”
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Murine LRBA deficiency causes CTLA‐4 deficiency in Tregs without progression to immune dysregulation by Burnett, Deborah L, Parish, Ian A, Masle‐Farquhar, Etienne, Brink, Robert, Goodnow, Christopher C

“…Inherited mutations in lipopolysaccharide‐responsive beige‐like anchor (LRBA) cause a recessive human immune dysregulation syndrome with memory B‐cell and…”
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Blending Traditional Vocational Services and Individualized Placement and Support for Formerly Incarcerated Veterans by LePage, James P, Crawford, April M, Cipher, Daisha J, Anderson, Kemol, Rock, Avery, Johnson, Julie A. Parish, Washington, Edward L, Ottomanelli, Lisa

“…Objective:This study compared two vocational programs: the About Face Vocational Program (AFVP), a traditional group-based vocational program created for…”
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Suppression of progesterone by influenza A virus mediates adverse maternal and fetal outcomes in mice by Creisher, Patrick S, Parish, Maclaine A, Lei, Jun, Liu, Jin, Perry, Jamie L, Campbell, Ariana D, Sherer, Morgan L, Burd, Irina, Klein, Sabra L

“…Influenza A virus infection during pregnancy can cause adverse maternal and fetal outcomes but the mechanism responsible remains elusive. Infection of outbred…”
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Individualized Placement and Support Supported Employment for Justice-involved Homeless and Unemployed Veterans by LePage, James P., Martin, William Blake, Crawford, April M., Rock, Avery, Parish Johnson, Julie A., Washington, Edward L.

“…Homelessness is a significant issue affecting the general US population. Two subsets of the population overrepresented in the US homeless population are…”
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FixNCut: single-cell genomics through reversible tissue fixation and dissociation by Jiménez-Gracia, Laura, Marchese, Domenica, Nieto, Juan C, Caratù, Ginevra, Melón-Ardanaz, Elisa, Gudiño, Victoria, Roth, Sara, Wise, Kellie, Ryan, Natalie K, Jensen, Kirk B, Hernando-Momblona, Xavier, Bernardes, Joana P, Tran, Florian, Sievers, Laura Katharina, Schreiber, Stefan, van den Berge, Maarten, Kole, Tessa, van der Velde, Petra L, Nawijn, Martijn C, Rosenstiel, Philip, Batlle, Eduard, Butler, Lisa M, Parish, Ian A, Plummer, Jasmine, Gut, Ivo, Salas, Azucena, Heyn, Holger, Martelotto, Luciano G

“…The use of single-cell technologies for clinical applications requires disconnecting sampling from downstream processing steps. Early sample preservation can…”
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Antigen-driven EGR2 expression is required for exhausted CD8+ T cell stability and maintenance by Wagle, Mayura V., Vervoort, Stephin J., Kelly, Madison J., Van Der Byl, Willem, Peters, Timothy J., Martin, Ben P., Martelotto, Luciano G., Nüssing, Simone, Ramsbottom, Kelly M., Torpy, James R., Knight, Deborah, Reading, Sinead, Thia, Kevin, Miosge, Lisa A., Howard, Debbie R., Gloury, Renee, Gabriel, Sarah S., Utzschneider, Daniel T., Oliaro, Jane, Powell, Jonathan D., Luciani, Fabio, Trapani, Joseph A., Johnstone, Ricky W., Kallies, Axel, Goodnow, Christopher C., Parish, Ian A.

“…Chronic stimulation of CD8 + T cells triggers exhaustion, a distinct differentiation state with diminished effector function. Exhausted cells exist in multiple…”
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Changes in Renal Function Associated with Tenofovir Disoproxil Fumarate Treatment, Compared with Nucleoside Reverse-Transcriptase Inhibitor Treatment by Gallant, Joel E., Parish, Michelle A., Keruly, Jeanne C., Moore, Richard D.

“…In our large observational cohort, use of tenofovir disoproxil fumarate (n = 344) was associated with a greater decline in renal function than was use of…”
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The Lipofuscin Fluorophore A2E Mediates Blue Light-Induced Damage to Retinal Pigmented Epithelial Cells by Sparrow, Janet R, Nakanishi, Koji, Parish, Craig A

“…To determine whether the lipofuscin fluorophore A2E participates in blue light-induced damage to retinal pigmented epithelial (RPE) cells. Human RPE cells…”
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Cross-presentation, dendritic cell subsets, and the generation of immunity to cellular antigens by Heath, William R., Belz, Gabrielle T., Behrens, Georg M. N., Smith, Christopher M., Forehan, Simon P., Parish, Ian A., Davey, Gayle M., Wilson, Nicholas S., Carbone, Francis R., Villadangos, Jose A.

“…Cross‐presentation involves the uptake and processing of exogenous antigens within the major histocompatibility complex (MHC) class I pathway. This process is…”
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A2AR eGFP reporter mouse enables elucidation of A2AR expression dynamics during anti-tumor immune responses by Todd, Kirsten L., Lai, Junyun, Sek, Kevin, Huang, Yu-Kuan, Newman, Dane M., Derrick, Emily B., Koay, Hui-Fern, Nguyen, Dat, Hoang, Thang X., Petley, Emma V., Chan, Cheok Weng, Munoz, Isabelle, House, Imran G., Lee, Joel N., Kim, Joelle S., Li, Jasmine, Tong, Junming, N. de Menezes, Maria, Scheffler, Christina M., Yap, Kah Min, Chen, Amanda X. Y., Dunbar, Phoebe A., Haugen, Brandon, Parish, Ian A., Johnstone, Ricky W., Darcy, Phillip K., Beavis, Paul A.

“…There is significant clinical interest in targeting adenosine-mediated immunosuppression, with several small molecule inhibitors having been developed for…”
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