Search Results - "Parikh, Kathan"

Histone induced platelet aggregation is inhibited by normal albumin by Lam, Fong W, Cruz, Miguel A, Leung, Hon-Chiu E, Parikh, Kathan S, Smith, C. Wayne, Rumbaut, Rolando E

“…Abstract Introduction Histones are small, nuclear proteins that serve to package DNA. Recent reports suggest that extracellular histones, including histone H4,…”
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Naive T cells inhibit the outgrowth of intractable antigen-activated memory T cells: implications for T-cell immunotherapy by Sharma, Sandhya, Woods, Mae, Mehta, Naren U, Sauer, Tim, Parikh, Kathan S, Schmuck-Henneresse, Michael, Zhang, Huimin, Mehta, Birju, Brenner, Malcolm K, Heslop, Helen E, Rooney, Cliona M

“…BackgroundThe wider application of T cells targeting viral tumor-antigens via their native receptors is hampered by the failure to expand potent tumor-specific…”
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Histones stimulate von Willebrand factor release in vitro and in vivo by Lam, Fong W, Cruz, Miguel A, Parikh, Kathan, Rumbaut, Rolando E

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670 Development of a robust manufacturing process for AB-1015, an integrated circuit T cell (ICT) products, using targeted, CRISPR integration of transgenes by electroporation (CITE) editing by Mende, Ines, Tran, Ben, Chow, Kartoa, Kennedy, Mark, Kukreja, Monica, Smith, Jenessa B, Wang, Haixia, Dibian, Zain, Ha, Elisa, McRae, Tejon, Nguyen, Tanya, Saephan, Tommy, Clagett, Erin, Lang, Nathan, Lim, Raymond, Wu, Jason, Chang, Alice, Guiang, Liselle, Guner, Nadija, Gunturu, Swetha, Huang, Elizabeth, Lalchandani, Aditya, Lee, Max, Phillips, Sophia, Chang, Stephen, Chu, Eric, Zapata, Ryan, Chang, En-Hsiang, Dai, Rory, Kandarian, Fadi, Ko, Hayden, Nguyen, Anton, Nie, Wendy, Parikh, Kathan, Rios, Lindsay, Sun, Xiangle, Tran, Stella, Holman, Peter, Sirichoke, Tim

“…BackgroundAB-1015 is an autologous, integrated circuit T cell (ICT) product for the potential treatment of platinum-resistant ovarian cancer. AB-1015 includes…”
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CD70-specific CAR T cells have potent activity against acute myeloid leukemia without HSC toxicity by Sauer, Tim, Parikh, Kathan, Sharma, Sandhya, Omer, Bilal, Sedloev, David, Chen, Qian, Angenendt, Linus, Schliemann, Christoph, Schmitt, Michael, Müller-Tidow, Carsten, Gottschalk, Stephen, Rooney, Cliona M

“…The prognosis of patients with acute myeloid leukemia (AML) remains dismal, highlighting the need for novel innovative treatment strategies. The application of…”
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CD70-specific CAR T cells have potent activity against acute myeloid leukemia without HSC toxicity by Sauer, Tim, Parikh, Kathan, Sharma, Sandhya, Omer, Bilal, Sedloev, David, Chen, Qian, Angenendt, Linus, Schliemann, Christoph, Schmitt, Michael, Müller-Tidow, Carsten, Gottschalk, Stephen, Rooney, Cliona M.

“…The prognosis of patients with acute myeloid leukemia (AML) remains dismal, highlighting the need for novel innovative treatment strategies. The application of…”
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Treatment of Acute Myeloid Leukemia with T Cells Expressing Chimeric Antigen Receptors Directed to C-type Lectin-like Molecule 1 by Tashiro, Haruko, Sauer, Tim, Shum, Thomas, Parikh, Kathan, Mamonkin, Maksim, Omer, Bilal, Rouce, Rayne H., Lulla, Premal, Rooney, Cliona M., Gottschalk, Stephen, Brenner, Malcolm K.

“…The successful immunotherapy of acute myeloid leukemia (AML) has been hampered because most potential antigenic targets are shared with normal hematopoietic…”
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Constitutive Signaling from an Engineered IL7 Receptor Promotes Durable Tumor Elimination by Tumor-Redirected T Cells by Shum, Thomas, Omer, Bilal, Tashiro, Haruko, Kruse, Robert L, Wagner, Dimitrios L, Parikh, Kathan, Yi, Zhongzhen, Sauer, Tim, Liu, Daofeng, Parihar, Robin, Castillo, Paul, Liu, Hao, Brenner, Malcolm K, Metelitsa, Leonid S, Gottschalk, Stephen, Rooney, Cliona M

“…Successful adoptive T-cell immunotherapy of solid tumors will require improved expansion and cytotoxicity of tumor-directed T cells within tumors. Providing…”
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Modulating Interlukin-7 (IL-7) cytokine receptor signaling to enhance the persistence and anti-tumor efficacy of Epstein-Barr Virus (EBV) specific T-cells in EBV positive malignancies by Sharma, Sandhya, Shum, Thomas, Parikh, Kathan, Omer, Bilal, Rooney, Cliona

“…Abstract EBV-specific T-cells (EBVSTs) targeting viral proteins in EBV+ lymphoma patients have produced 50% clinical response. Limited T-cell expansion and…”
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CD70-Specific CAR T Cells Have Potent Activity Against Acute Myeloid Leukemia (AML) without HSC Toxicity by Sauer, Tim, Parikh, Kathan, Sharma, Sandhya, Omer, Bilal, Gottschalk, Stephen, Rooney, Cliona M.

“…The outcome for the majority of patients with AML remains dismal. Adoptive transfer of chimeric antigen receptor (CAR) modified T-cells (CARTs) holds the…”
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Phase I Trial of GD2.CART Cells Augmented With Constitutive Interleukin-7 Receptor for Treatment of High-Grade Pediatric CNS Tumors by Lin, Frank Y, Stuckert, Austin, Tat, Candise, White, Mark, Ruggieri, Lucia, Zhang, Huimin, Mehta, Birju, Lapteva, Natalia, Mei, Zhuyong, Major, Angela, Thakkar, Sachin, Shum, Thomas, Parikh, Kathan, Wu, Meng-Fen, Lindsay, Holly B, Scherer, Lauren, Shekar, Meghan, Baxter, Patricia, Wang, Tao, Grilley, Bambi, Moeller, Karen, Hicks, John, Roy, Angshumoy, Anastas, Jamie, Malbari, Fatema, Aldave, Guillermo, Chintagumpala, Murali, Blaney, Susan, Parsons, D Williams, Brenner, Malcolm K, Heslop, Helen E, Rooney, Cliona M, Omer, Bilal

“…T cells modified with chimeric antigen receptors (CARTs) have demonstrated efficacy for hematologic malignancies; however, benefit for patients with CNS tumors…”
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Histones Stimulate Ultra‐Large Von Willebrand Factor Release from Endothelium: A Potential Contributor to the Prothrombotic State in Sepsis by Lam, Fong, Cruz, Miguel, Parikh, Kathan, Rumbaut, Rolando

“…Abstract only…”
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Interaction between endotoxin and histones in thrombosis (671.5) by Lam, Fong, Parikh, Kathan, Cruz, Miguel, Rumbaut, Rolando

“…Histones, the protein component of nucleosomes, are released from neutrophils during inflammation and have a pro‐aggregatory effect on platelets. Recent…”
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Phase I Trial of GD2.CAR T Cells Combined with a Novel Interleukin-7 Signal Modulator by Omer, Bilal, Shum, Thomas, Foster, Jennifer, Parikh, Kathan, Tat, Candise, Shekar, Meghan, Vivekananthan, Annika, Mehta, Birju, Zhang, Huimin, Thakkar, Sachin G., Naik, Swati, Heslop, Helen E., Brenner, Malcolm K., Rooney, Cliona M.

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129 - Phase I Trial of GD2.CAR T Cells Combined with a Novel Interleukin-7 Signal Modulator by Omer, Bilal, Shum, Thomas, Foster, Jennifer, Parikh, Kathan, Tat, Candise, Shekar, Meghan, Vivekananthan, Annika, Mehta, Birju, Zhang, Huimin, Thakkar, Sachin G., Naik, Swati, Heslop, Helen E., Brenner, Malcolm K., Rooney, Cliona M.

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