Search Results - "Parikh, Anuraag"

Partial EMT in head and neck cancer biology: a spectrum instead of a switch by Pal, Ananya, Barrett, Thomas F., Paolini, Rachel, Parikh, Anuraag, Puram, Sidharth V.

“…Our understanding of epithelial-to-mesenchymal transition (EMT) has slowly evolved from a simple two state, binary model to a multi-step, dynamic continuum of…”
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Single-Cell Transcriptomic Analysis of Primary and Metastatic Tumor Ecosystems in Head and Neck Cancer by Puram, Sidharth V., Tirosh, Itay, Parikh, Anuraag S., Patel, Anoop P., Yizhak, Keren, Gillespie, Shawn, Rodman, Christopher, Luo, Christina L., Mroz, Edmund A., Emerick, Kevin S., Deschler, Daniel G., Varvares, Mark A., Mylvaganam, Ravi, Rozenblatt-Rosen, Orit, Rocco, James W., Faquin, William C., Lin, Derrick T., Regev, Aviv, Bernstein, Bradley E.

“…The diverse malignant, stromal, and immune cells in tumors affect growth, metastasis, and response to therapy. We profiled transcriptomes of ∼6,000 single…”
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Single-cell sequencing and its applications in head and neck cancer by Qi, Zongtai, Barrett, Thomas, Parikh, Anuraag S., Tirosh, Itay, Puram, Sidharth V.

“…•Head and neck squamous cell carcinoma (HNSCC) is characterized by significant intra-tumoral heterogeneity.•Single-cell sequencing (SCS) technologies provide…”
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Patterns of concurrent cigarette, alcohol, and e‐cigarette use: Off‐setting or additive behaviors? by Parikh, Anuraag S., Bhattacharyya, Neil

“…Objectives To understand nationwide concurrent use of e‐cigarettes (Ecig) with alcohol and conventional cigarettes (Ccig), the major risk factors for head and…”
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Does Clearance of Positive Margins Improve Local Control in Oral Cavity Cancer? A Meta-analysis by Bulbul, Mustafa G., Tarabichi, Osama, Sethi, Rosh K., Parikh, Anuraag S., Varvares, Mark A.

“…Objectives To compare local recurrence-free survival (LRFS) in early oral cavity cancer (OCC) patients with positive/close frozen section (FS) cleared with…”
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Margin Practices in Oral Cavity Cancer Resections: Survey of American Head and Neck Society Members by Bulbul, Mustafa G., Zenga, Joseph, Tarabichi, Osama, Parikh, Anuraag S., Sethi, Rosh K., Robbins, K. Thomas, Puram, Sidharth V., Varvares, Mark A.

“…Objectives/Hypothesis To investigate the definition of a clear margin and the use of frozen section (FS) among practicing head and neck surgeons in oral cancer…”
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Variation in elective treatment of the contralateral neck in oropharyngeal cancer by Parikh, Anuraag S., Kang, Stephen Y.

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RNA sequencing and expression heterogeneity in head and neck cancer by Parikh, Anuraag S., Puram, Sidharth V.

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Single cell RNA-seq highlights a role for a partial EMT in head and neck cancer by Puram, Sidharth V., Parikh, Anuraag S., Tirosh, Itay

“…Studies in single cell transcriptomics have significantly expanded our understanding of tumor biology, including recent analyses in head and neck squamous cell…”
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Immunohistochemical quantification of partial-EMT in oral cavity squamous cell carcinoma primary tumors is associated with nodal metastasis by Parikh, Anuraag S., Puram, Sidharth V., Faquin, William C., Richmon, Jeremy D., Emerick, Kevin S., Deschler, Daniel G., Varvares, Mark A., Tirosh, Itay, Bernstein, Bradley E., Lin, Derrick T.

“…•Tissue microarrays were created from 99 oral cavity carcinoma patients.•Immunohistochemical quantification of partial-EMT was performed using 4 markers.•P-EMT…”
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Impact of surgical margins on local control in patients undergoing single‐modality transoral robotic surgery for HPV‐related oropharyngeal squamous cell carcinoma by Holcomb, Andrew J., Herberg, Matthew, Strohl, Madeleine, Ochoa, Edgar, Feng, Allen L., Abt, Nicholas B., Mokhtari, Tara E., Suresh, Krish, McHugh, Christopher I., Parikh, Anuraag S., Sadow, Peter, Faquin, William, Faden, Daniel, Deschler, Daniel G., Varvares, Mark A., Lin, Derrick T., Fakhry, Carole, Ryan, William R., Richmon, Jeremy D.

“…Background The impact of close surgical margins on oncologic outcomes in HPV‐related oropharyngeal squamous cell carcinoma (HPV + OPSCC) is unclear. Methods…”
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The utility of intra-oral ultrasound in improving deep margin clearance of oral tongue cancer resections by Bulbul, Mustafa G., Tarabichi, Osama, Parikh, Anuraag S., Yoon, Byung C., Juliano, Amy, Sadow, Peter M., Faquin, William, Gropler, Matthew, Walker, Ronald, Puram, Sidharth V., Varvares, Mark A.

“…•Ultrasound (US) is a potential tool in guiding oral tongue cancer (OTC) resections.•US depth of invasion (DOI) highly correlates with histologic DOI…”
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Advancements in TGF-β Targeting Therapies for Head and Neck Squamous Cell Carcinoma by Britton, William R, Cioffi, Isabel, Stonebraker, Corinne, Spence, Matthew, Okolo, Ogoegbunam, Martin, Cecilia, Henick, Brian, Nakagawa, Hiroshi, Parikh, Anuraag S

“…Head and neck squamous cell carcinoma (HNSCC) is the sixth leading cause of cancer worldwide according to GLOBOCAN estimates from 2022. Current therapy options…”
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Stage Migration and Survival Trends in Laryngeal Cancer by Li, Michael M., Zhao, Songzhu, Eskander, Antoine, Rygalski, Chandler, Brock, Guy, Parikh, Anuraag S., Haring, Catherine T., Swendseid, Brian, Zhan, Kevin Y., Bradford, Carol R., Teknos, Theodoros N., Carrau, Ricardo L., VanKoevering, Kyle K., Seim, Nolan B., Old, Matthew O., Rocco, James W., Puram, Sidharth V., Kang, Stephen Y.

“…Background During the last two decades, significant advancements in the treatment of laryngeal cancer have occurred. Although survival of head and neck cancer…”
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Cellular states are coupled to genomic and viral heterogeneity in HPV-related oropharyngeal carcinoma by Puram, Sidharth V., Mints, Michael, Pal, Ananya, Qi, Zongtai, Reeb, Ashley, Gelev, Kyla, Barrett, Thomas F., Gerndt, Sophie, Liu, Ping, Parikh, Anuraag S., Ramadan, Salma, Law, Travis, Mroz, Edmund A., Rocco, James W., Adkins, Doug, Thorstad, Wade L., Gay, Hiram A., Ding, Li, Paniello, Randal C., Pipkorn, Patrik, Jackson, Ryan S., Wang, Xiaowei, Mazul, Angela, Chernock, Rebecca, Zevallos, Jose P., Silva-Fisher, Jessica, Tirosh, Itay

“…Head and neck squamous cell carcinoma (HNSCC) includes a subset of cancers driven by human papillomavirus (HPV). Here we use single-cell RNA-seq to profile…”
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Patient-derived three-dimensional culture techniques model tumor heterogeneity in head and neck cancer by Parikh, Anuraag S., Yu, Victoria X., Flashner, Samuel, Okolo, Ogoegbunam B., Lu, Chao, Henick, Brian S., Momen-Heravi, Fatemeh, Puram, Sidharth V., Teknos, Theodoros, Pan, Quintin, Nakagawa, Hiroshi

“…•Two-dimensional (2D) cell line models fail to capture tumor heterogeneity.•3D patient derived organoids capture heterogeneity and predict treatment…”
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Understanding approaches to measurement and impact of depth of invasion of oral cavity cancers: A survey of American Head and Neck Society Membership by Bulbul, Mustafa G., Zenga, Joseph, Puram, Sidharth V., Tarabichi, Osama, Parikh, Anuraag S., Varvares, Mark A.

“…•Depth of invasion (DOI) has become part of the T-staging for oral cavity cancers.•Most surgeons measure DOI pre-operatively using manual palpation or punch…”
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Skull Base Osteomyelitis Complicated by Petrous Internal Carotid Artery Blowout by Weitzman, Rachel E., Parikh, Anuraag S., Gadkaree, Shekhar K., Corrales, C. Eduardo

“…Skull base osteomyelitis (SBO) is an invasive infection of the external auditory canal, with involvement of the skull base, typically in the elderly diabetic…”
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Single-cell RNA sequencing identifies a paracrine interaction that may drive oncogenic notch signaling in human adenoid cystic carcinoma by Parikh, Anuraag S., Wizel, Avishai, Davis, Daniel, Lefranc-Torres, Armida, Rodarte-Rascon, Alejandro I., Miller, Lauren E., Emerick, Kevin S., Varvares, Mark A., Deschler, Daniel G., Faquin, William C., Aster, Jon C., Lin, Derrick T., Bernstein, Bradley E., Drier, Yotam, Puram, Sidharth V.

“…Salivary adenoid cystic carcinoma (ACC) is a rare, biologically unique biphasic tumor that consists of malignant myoepithelial and luminal cells. MYB and Notch…”
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Predictors of survival following carotid blowout syndrome by Silverman, Dustin A., Parikh, Anuraag S., Liu, Kevin, Zhan, Kevin Y., Nimjee, Shahid M., Powers, Ciaran J., Youssef, Patrick, Rocco, James W., VanKoevering, Kyle K., Kang, Stephen Y., Old, Matthew O., Seim, Nolan B.

“…•Following CBS, 30-day and 1-year OS rates are 70.1% and 32.0%, respectively.•Predictors of survival: oropharyngeal/active tumors, ICA/CCA rupture, acute…”
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