Search Results - "Parihar, Suraj P."

Transcriptional landscape of Mycobacterium tuberculosis infection in macrophages by Roy, Sugata, Schmeier, Sebastian, Kaczkowski, Bogumil, Arner, Erik, Alam, Tanvir, Ozturk, Mumin, Tamgue, Ousman, Parihar, Suraj P., Kawaji, Hideya, Itoh, Masayoshi, Lassmann, Timo, Carninci, Piero, Hayashizaki, Yoshihide, Forrest, Alistair R. R., Guler, Reto, Bajic, Vladimir B., Brombacher, Frank, Suzuki, Harukazu

“…Mycobacterium tuberculosis (Mtb) infection reveals complex and dynamic host-pathogen interactions, leading to host protection or pathogenesis. Using a unique…”
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Differential requirement of formyl peptide receptor 1 in macrophages and neutrophils in the host defense against Mycobacterium tuberculosis Infection by Nafiz, Tanvir Noor, Sankar, Poornima, Mishra, Lokesh K., Rousseau, Robert P., Saqib, Mohd, Subbian, Selvakumar, Parihar, Suraj P., Mishra, Bibhuti B.

“…Formyl peptide receptors (FPR), part of the G-protein coupled receptor superfamily, are pivotal in directing phagocyte migration towards chemotactic signals…”
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Targeting Molecular Inflammatory Pathways in Granuloma as Host-Directed Therapies for Tuberculosis by Guler, Reto, Ozturk, Mumin, Sabeel, Solima, Motaung, Bongani, Parihar, Suraj P, Thienemann, Friedrich, Brombacher, Frank

“…Globally, more than 10 million people developed active tuberculosis (TB), with 1.4 million deaths in 2020. In addition, the emergence of drug-resistant strains…”
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Batf2/Irf1 induces inflammatory responses in classically activated macrophages, lipopolysaccharides, and mycobacterial infection by Roy, Sugata, Guler, Reto, Parihar, Suraj P, Schmeier, Sebastian, Kaczkowski, Bogumil, Nishimura, Hajime, Shin, Jay W, Negishi, Yutaka, Ozturk, Mumin, Hurdayal, Ramona, Kubosaki, Atsutaka, Kimura, Yasumasa, de Hoon, Michiel J L, Hayashizaki, Yoshihide, Brombacher, Frank, Suzuki, Harukazu

“…Basic leucine zipper transcription factor Batf2 is poorly described, whereas Batf and Batf3 have been shown to play essential roles in dendritic cell, T cell,…”
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The divergent outcome of IL-4Rα signalling on Foxp3 T regulatory cells in listeriosis and tuberculosis by Chia, Julius E, Rousseau, Robert P, Ozturk, Mumin, Poswayo, Sibongiseni K L, Lucas, Rodney, Brombacher, Frank, Parihar, Suraj P

“…Forkhead box P3 (Foxp3) T regulatory cells are critical for maintaining self-tolerance, immune homeostasis, and regulating the immune system. We investigated…”
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Arteannuin-B and (3-Chlorophenyl)-2-Spiroisoxazoline Derivative Exhibit Anti-Inflammatory Effects in LPS-Activated RAW 264.7 Macrophages and BALB/c Mice-Induced Proinflammatory Responses via Downregulation of NF-κB/P38 MAPK Signaling by Sawhney, Gifty, Rasool, Javeed Ur, Saroch, Diksha, Ozturk, Mumin, Brombacher, Frank, Ahmad, Bilal, Bhagat, Asha, Ali, Asif, Parihar, Suraj P, Ahmed, Zabeer

“…Host inflammatory responses are key to protection against injury; however, persistent inflammation is detrimental and contributes to morbidity and mortality…”
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Evaluation of Berberine as an Adjunct to TB Treatment by Ozturk, Mumin, Chia, Julius E, Hazra, Rudranil, Saqib, Mohd, Maine, Rebeng A, Guler, Reto, Suzuki, Harukazu, Mishra, Bibhuti B, Brombacher, Frank, Parihar, Suraj P

“…Tuberculosis (TB) is the global health problem with the second highest number of deaths from a communicable disease after COVID-19. Although TB is curable,…”
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Spatial Metagenomic Analysis in Understanding the Microbial Diversity of Thar Desert by Parihar, Jagdish, Parihar, Suraj P, Suravajhala, Prashanth, Bagaria, Ashima

“…The arid and semi-arid regions of Rajasthan are one of the most extreme biomes of India, possessing diverse microbial communities that exhibit immense…”
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Editorial: Repurposed Drugs as Immune-Modulators to Combat Infectious Diseases by Mishra, Bibhuti B, Essafi, Makram, Singh, Ramandeep, Gupta, Shashank, Parihar, Suraj P

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IL-4-Responsive B Cells Are Detrimental During Chronic Tuberculosis Infection in Mice by Parihar, Suraj P., Ozturk, Mumin, Höft, Maxine A., Chia, Julius E., Guler, Reto, Keeton, Roanne, van Rensburg, Ilana C., Loxton, Andre G., Brombacher, Frank

“…In tuberculosis, T cell-mediated immunity is extensively studied whilst B cells received limited attention in human and mice. Of interest, Mycobacterium…”
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Redefining the transcriptional regulatory dynamics of classically and alternatively activated macrophages by deepCAGE transcriptomics by Roy, Sugata, Schmeier, Sebastian, Arner, Erik, Alam, Tanvir, Parihar, Suraj P, Ozturk, Mumin, Tamgue, Ousman, Kawaji, Hideya, de Hoon, Michiel J L, Itoh, Masayoshi, Lassmann, Timo, Carninci, Piero, Hayashizaki, Yoshihide, Forrest, Alistair R R, Bajic, Vladimir B, Guler, Reto, Brombacher, Frank, Suzuki, Harukazu

“…Classically or alternatively activated macrophages (M1 and M2, respectively) play distinct and important roles for microbiocidal activity, regulation of…”
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Lyl1-deficiency promotes inflammatory responses and increases mycobacterial burden in response to Mycobacterium tuberculosis infection in mice by Jones, Shelby-Sara, Ozturk, Mumin, Kieswetter, Nathan Scott, Poswayo, Sibongiseni K L, Hazra, Rudranil, Tamgue, Ousman, Parihar, Suraj P, Suzuki, Harukazu, Brombacher, Frank, Guler, Reto

“…Lymphoblastic leukemia 1 (Lyl1) is a well-studied transcription factor known to exhibit oncogenic potential in various forms of leukemia with pivotal roles in…”
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Statins: a viable candidate for host-directed therapy against infectious diseases by Parihar, Suraj P., Guler, Reto, Brombacher, Frank

“…Statins were first identified over 40 years ago as lipid-lowering drugs and have been remarkably effective in treating cardiovascular diseases. As research…”
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Omega-3 Fatty Acid and Iron Supplementation Alone, but Not in Combination, Lower Inflammation and Anemia of Infection in Mycobacterium tuberculosis -Infected Mice by Nienaber, Arista, Baumgartner, Jeannine, Dolman, Robin C, Ozturk, Mumin, Zandberg, Lizelle, Hayford, Frank E A, Brombacher, Frank, Blaauw, Renee, Parihar, Suraj P, Smuts, Cornelius M, Malan, Linda

“…Progressive inflammation and anemia are common in tuberculosis (TB) and linked to poor clinical outcomes. Eicosapentaenoic acid (EPA) and docosahexaenoic acid…”
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Deletion of IL-4 receptor alpha on dendritic cells renders BALB/c mice hypersusceptible to Leishmania major infection by Hurdayal, Ramona, Nieuwenhuizen, Natalie E, Revaz-Breton, Mélanie, Smith, Liezel, Hoving, Jennifer C, Parihar, Suraj P, Reizis, Boris, Brombacher, Frank

“…In BALB/c mice, susceptibility to infection with the intracellular parasite Leishmania major is driven largely by the development of T helper 2 (Th2) responses…”
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Simvastatin enhances protection against Listeria monocytogenes infection in mice by counteracting Listeria-induced phagosomal escape by Parihar, Suraj P, Guler, Reto, Lang, Dirk M, Suzuki, Harukazu, Marais, A David, Brombacher, Frank

“…Statins are well-known cholesterol lowering drugs targeting HMG-CoA-reductase, reducing the risk of coronary disorders and hypercholesterolemia. Statins are…”
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IL-4Rα-dependent alternative activation of macrophages is not decisive for Mycobacterium tuberculosis pathology and bacterial burden in mice by Guler, Reto, Parihar, Suraj P, Savvi, Suzana, Logan, Erin, Schwegmann, Anita, Roy, Sugata, Nieuwenhuizen, Natalie E, Ozturk, Mumin, Schmeier, Sebastian, Suzuki, Harukazu, Brombacher, Frank

“…Classical activation of macrophages (caMph or M1) is crucial for host protection against Mycobacterium tuberculosis (Mtb) infection. Evidence suggests that…”
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Viral Apoptosis Evasion via the MAPK Pathway by Use of a Host Long Noncoding RNA by Barichievy, Samantha, Naidoo, Jerolen, Boullé, Mikaël, Scholefield, Janine, Parihar, Suraj P, Coussens, Anna K, Brombacher, Frank, Sigal, Alex, Mhlanga, Musa M

“…An emerging realization of infectious disease is that pathogens can cause a high incidence of genetic instability within the host as a result of…”
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Longer-Term Omega-3 LCPUFA More Effective Adjunct Therapy for Tuberculosis Than Ibuprofen in a C3HeB/FeJ Tuberculosis Mouse Model by Hayford, Frank E A, Ozturk, Mumin, Dolman, Robin C, Blaauw, Renee, Nienaber, Arista, Loots, Du Toit, Brombacher, Frank, Smuts, Cornelius M, Parihar, Suraj P, Malan, Linda

“…Advancement in the understanding of inflammation regulation during tuberculosis (TB) treatment has led to novel therapeutic approaches being proposed. The use…”
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Adjunct n-3 Long-Chain Polyunsaturated Fatty Acid Treatment in Tuberculosis Reduces Inflammation and Improves Anemia of Infection More in C3HeB/FeJ Mice With Low n-3 Fatty Acid Status Than Sufficient n-3 Fatty Acid Status by Hayford, Frank E A, Dolman, Robin C, Ozturk, Mumin, Nienaber, Arista, Ricci, Cristian, Loots, Du Toit, Brombacher, Frank, Blaauw, Renée, Smuts, Cornelius M, Parihar, Suraj P, Malan, Linda

“…Populations at risk for tuberculosis (TB) may have a low n-3 polyunsaturated fatty acid (PUFA) status. Our research previously showed that post-infection…”
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