Search Results - "Parihar, Ashutosh S."

Overcoming Acquired Drug Resistance to Cancer Therapies through Targeted STAT3 Inhibition by Singh, Sunanda, Gomez, Hector J, Thakkar, Shreya, Singh, Samara P, Parihar, Ashutosh S

“…Anti-neoplastic agents for cancer treatment utilize many different mechanisms of action and, when combined, can result in potent inhibition of cancer growth…”
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A Broad-Based Characterization of a Cell-Penetrating, Single Domain Camelid Bi-Specific Antibody Monomer That Targets STAT3 and KRAS Dependent Cancers by Singh, Sunanda, Murillo, Genoveva, Richner, Justin, Singh, Samara P., Berleth, Erica, Kumar, Vijay, Mehta, Rajendra, Ramiya, Vijay, Parihar, Ashutosh S.

“…STAT3 and KRAS regulate cell proliferation, survival, apoptosis, cell migration, and angiogenesis. Aberrant expression of STAT3 and mutant active forms of KRAS…”
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Suppression of Breast Cancer Cell Proliferation by Selective Single-Domain Antibody for Intracellular STAT3 by Singh, Sunanda, Murillo, Genoveva, Chen, Dong, Parihar, Ashutosh S, Mehta, Rajendra G

“…Background: The serendipitous discovery of heavy-chain antibodies devoid of light chains in camelids and the subsequent development of VHHs (variable region of…”
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The discovery of a new class of large-conductance Ca2+-activated K+ channel opener targeted for overactive bladder: Synthesis and structure-activity relationships of 2-amino-4-azaindoles by TURNER, Sean C, CARROLL, William A, SULLIVAN, James P, WHITE, Tammie K, GOPALAKRISHNAN, Murali, COGHLAN, Michael J, SHIEH, Char-Chang, ZHANG, Xu-Feng, PARIHAR, Ashutosh S, BUCKNER, Steven A, MILICIC, Ivan

“…2-Amino-4-azaindoles have been identified as a structurally novel class of BK(Ca) channel openers. Their synthesis from 2-chloro-3-nitropyridine is described…”
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Effects of intermediate-conductance Ca2+-activated K+ channel modulators on human prostate cancer cell proliferation by PARIHAR, Ashutosh S, COGHLAN, Michael J, GOPALAKRISHNAN, Murali, SHIEH, Char-Chang

“…The effects of 1-ethyl-2-benzimidazolinone (1-EBIO) and riluzole on human prostate cancer cells, LNCaP and PC-3, were evaluated using rubidium (86Rb(+)) efflux…”
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Functional analysis of large conductance Ca2(+)-activated K(+) channels: ion flux studies by atomic absorption spectrometry by Parihar, Ashutosh S, Groebe, Duncan R, Scott, Victoria E, Feng, Jianlin, Zhang, Xu-Feng, Warrior, Usha, Gopalakrishnan, Murali, Shieh, Char-Chang

“…Although techniques such as (86)Rb(+) flux provide a sensitive measure of K(+) channel activity, the relatively short half-life and high-energy emission,…”
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Automated Parallel Oocyte Electrophysiology Test station (POETs): a screening platform for identification of ligand-gated ion channel modulators by Shieh, Char-Chang, Trumbull, Jonathan D, Sarthy, Jay F, McKenna, David G, Parihar, Ashutosh S, Zhang, Xu-Feng, Faltynek, Connie R, Gopalakrishnan, Murali

“…Ligand-gated ion channels (LGICs) play important roles in the regulation of cellular function and signaling and serve as excellent drug targets. However, fast…”
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Single domain antibody (SBT-100) crosses the blood brain barrier (BBB) and inhibits human glioblastoma by selectively targeting KRAS and P-STAT3 by Singh, Sunanda, Murillo, Genoveva, Singh, Avani, Singh, Samara, Parihar, Meenakshi S, Singh, Anjali H, Mehta, Rajendra, Parihar, Ashutosh S

“…Abstract only e13547 Background: Glioblastoma is difficult to treat malignancy that has a high incidence of KRAS mutations ( > 90%) and hyper-expression of…”
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Effect of KRAS and P-STAT3 inhibition by SBT-100 on gemcitabine and pancreatic cancer growth in vivo by Singh, Sunanda, Murillo, Genoveva, Singh, Avani, Singh, Samara, Parihar, Meenakshi S, Singh, Anjali H, Mehta, Rajendra, Parihar, Ashutosh S

“…Abstract only e15727 Background: Over 90% of pancreatic cancers have KRAS mutations and hyper-expression of P-STAT3 oncoproteins, which if specifically…”
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A novel single domain antibody (sdAb) SBT-100 targeting intracellular STAT3 to inhibit major subtypes of human breast cancer by Singh, Sunanda, Murillo, Genoveva, Mehta, Rajendra, Chen, Dong, Singh, Avani, Singh, Samara, Singh, Anjali, Parihar, Ashutosh S

“…Abstract only…”
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A novel single domain antibody (sdAb) SBT-100 to target intracellular STAT3 to affect growth and regression of human triple negative breast cancer (TNBC) cells by Singh, Sunanda, Murillo, Genoveva, Mehta, Rajendra, Chen, Dong, Singh, Avani, Singh, Samara, Singh, Anjali, Parihar, Ashutosh S

“…Abstract only…”
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Abstract 4699: Single domain antibody (sdAb) localizes in cancer cells to inhibit signal transducer and activator of transcription 3 (STAT3) resulting in therapeutic inhibition of multiple cancers by Singh, Sunanda, Murillo, Genoveva, Rom, Amanda, Singh, Avani, Singh, Samara, Parihar, Meenakshi, Chen, Dong, Mehta, Rajendra, Baker, Robert, Singh, Anjali, Parihar, Ashutosh S.

“…Abstract STAT3 is involved in the pathogenesis of many malignancies, so we developed an anti-STAT3 VHH (variable region of the heavy chain), SBT-100, that…”
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High throughput electrophysiology using a fully automated, multiplexed recording system by Trumbull, Jonathan D, Maslana, Eugene S, McKenna, David G, Nemcek, Thomas A, Niforatos, Wende, Pan, Jeffrey Y, Parihar, Ashutosh S, Shieh, Char-Chang, Wilkins, Julie A, Briggs, Clark A, Bertrand, Daniel

“…The drug discovery process centers around finding and optimizing novel compounds active at therapeutic targets. This process involves direct and indirect…”
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Species-related pharmacological heterogeneity of histamine H3 receptors by IRELAND-DENNY, Lynne, PARIHAR, Ashutosh S, MILLER, Thomas R, KANG, Chae H, KRUEGER, Kathleen M, ESBENSHADE, Timothy A, HANCOCK, Arthur A

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Species-related pharmacological heterogeneity of histamine H 3 receptors by Ireland-Denny, Lynne, Parihar, Ashutosh S, Miller, Thomas R, Kang, Chae H, Krueger, Kathleen M, Esbenshade, Timothy A, Hancock, Arthur A

“…We compared radioligand binding and functional data for histamine H 3 receptor ligands across different tissues or species to evaluate the basis for…”
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Effects of intermediate-conductance Ca 2+-activated K + channel modulators on human prostate cancer cell proliferation by Parihar, Ashutosh S., Coghlan, Michael J., Gopalakrishnan, Murali, Shieh, Char-Chang

“…The effects of 1-ethyl-2-benzimidazolinone (1-EBIO) and riluzole on human prostate cancer cells, LNCaP and PC-3, were evaluated using rubidium ( 86Rb +) efflux…”
Get full text

The discovery of a new class of large-conductance Ca 2+-activated K + channel opener targeted for overactive bladder: synthesis and structure–activity relationships of 2-amino-4-azaindoles by Turner, Sean C., Carroll, William A., White, Tammie K., Gopalakrishnan, Murali, Coghlan, Michael J., Shieh, Char-Chang, Zhang, Xu-Feng, Parihar, Ashutosh S., Buckner, Steven A., Milicic, Ivan, Sullivan, James P.

“…2-Amino-4-azaindoles have been identified as a structurally novel class of BK Ca channel openers. Their synthesis from 2-chloro-3-nitropyridine is described…”
Get full text