The Difference of Serum Gastrin-17 Level Based on Gastritis Severity and Helicobacter Pylori Infection

Gastritis was defined as the histological presence of gastric mucosal inflammation. One of the most common aetiology was . Gastrin-17 was a hormone that was secreted by G cells. infection induced increased in gastrin-17 in gastritis. Therefore, this study was to investigate the relationship of gastr...

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Bibliographic Details
Published in:	Open access Macedonian journal of medical sciences Vol. 7; no. 8; pp. 1266 - 1269
Main Authors:	Parhusip, Dumawan Harris, Siregar, Gontar Alamsyah, Dairi, Leonardo Basa
Format:	Journal Article
Language:	English
Published:	Macedonia Republic of Macedonia 30-04-2019
Subjects:	Basic Science Helicobacter pylori Gastrin-17 Gastritis
Online Access:	Get full text
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Summary:	Gastritis was defined as the histological presence of gastric mucosal inflammation. One of the most common aetiology was . Gastrin-17 was a hormone that was secreted by G cells. infection induced increased in gastrin-17 in gastritis. Therefore, this study was to investigate the relationship of gastrin-17 with gastritis severity and infection. To determine the difference in serum Gastrin-17 level based on gastritis severity and infection. A cross-sectional study enrolling 45 patients with gastritis was conducted in Haji Adam Malik General Hospital between April and July 2018. Endoscopy and biopsy examinations were performed to confirm the diagnosis of gastritis. Gastritis severity was assessed using the Updated Sydney System. The presence of infection was detected by a Campylobacter-like organism (CLO) examination. Gastrin-17 level and demographic data were also gathered. The analysis was done using Mann Whitney and Kruskal-Wallis test. P-value of < 0.05 was considered statistically significant. Serum Gastrin-17 level was significantly different based on gastritis severity (P = 0.001 according to neutrophils infiltration and P = 0.023 according to degree of atrophy), infection (P = 0.038), and combined gastritis severity and infection (P < 0.001). Serum Gastrin-17 level was higher in subjects with severe neutrophils infiltration, without atrophy, and with infection. There was a significant difference in serum Gastrin-17 level based on gastritis severity and infection.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1857-9655 1857-9655
DOI:	10.3889/oamjms.2019.325