Search Results - "Parhiz, Hamideh"

Molecular mechanisms behind the biological effects of hesperidin and hesperetin for the prevention of cancer and cardiovascular diseases by Roohbakhsh, Ali, Parhiz, Hamideh, Soltani, Fatemeh, Rezaee, Ramin, Iranshahi, Mehrdad

“…Hesperidin (Hsd) and its aglycone, hesperetin (Hst), are two flavonoids from citrus species that have various biological properties, particularly those for the…”
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Protective effects of flavonoids against microbes and toxins: The cases of hesperidin and hesperetin by Iranshahi, Mehrdad, Rezaee, Ramin, Parhiz, Hamideh, Roohbakhsh, Ali, Soltani, Fatemeh

“…Many plants produce flavonoids as secondary metabolites. These organic compounds may be involved in the defense against plant-threatening factors, such as…”
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Neuropharmacological properties and pharmacokinetics of the citrus flavonoids hesperidin and hesperetin — A mini-review by Roohbakhsh, Ali, Parhiz, Hamideh, Soltani, Fatemeh, Rezaee, Ramin, Iranshahi, Mehrdad

“…Hesperidin (Hsd) and its aglycone, hesperetin (Hst), are two flavonoids from citrus species that have various biological properties. Over the past decade, a…”
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Novel potential therapeutics to modify iron metabolism and red cell synthesis in diseases associated with defective erythropoiesis by Guerra, Amaliris, Parhiz, Hamideh, Rivella, Stefano

“…Under normal conditions, iron metabolism is carefully regulated to sustain normal cellular functions and the production of hemoglobin in erythroid cells…”
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Synthetic and Biological Vesicular Nano-Carriers Designed for Gene Delivery by Soltani, Fatemeh, Parhiz, Hamideh, Mokhtarzadeh, Ahad, Ramezani, Mohammad

“…Synthetic and biological vesicular carriers have been recognized as attractive and intelligent systems for delivery of a verity of bioactive molecules. The…”
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A Global Review on Short Peptides: Frontiers and Perspectives by Apostolopoulos, Vasso, Bojarska, Joanna, Chai, Tsun-Thai, Elnagdy, Sherif, Kaczmarek, Krzysztof, Matsoukas, John, New, Roger, Parang, Keykavous, Lopez, Octavio Paredes, Parhiz, Hamideh, Perera, Conrad O, Pickholz, Monica, Remko, Milan, Saviano, Michele, Skwarczynski, Mariusz, Tang, Yefeng, Wolf, Wojciech M, Yoshiya, Taku, Zabrocki, Janusz, Zielenkiewicz, Piotr, AlKhazindar, Maha, Barriga, Vanessa, Kelaidonis, Konstantinos, Sarasia, Elham Mousavinezhad, Toth, Istvan

“…Peptides are fragments of proteins that carry out biological functions. They act as signaling entities via all domains of life and interfere with…”
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Red blood cell-hitchhiking boosts delivery of nanocarriers to chosen organs by orders of magnitude by Brenner, Jacob S., Pan, Daniel C., Myerson, Jacob W., Marcos-Contreras, Oscar A., Villa, Carlos H., Patel, Priyal, Hekierski, Hugh, Chatterjee, Shampa, Tao, Jian-Qin, Parhiz, Hamideh, Bhamidipati, Kartik, Uhler, Thomas G., Hood, Elizabeth D., Kiseleva, Raisa Yu, Shuvaev, Vladimir S., Shuvaeva, Tea, Khoshnejad, Makan, Johnston, Ian, Gregory, Jason V., Lahann, Joerg, Wang, Tao, Cantu, Edward, Armstead, William M., Mitragotri, Samir, Muzykantov, Vladimir

“…Drug delivery by nanocarriers (NCs) has long been stymied by dominant liver uptake and limited target organ deposition, even when NCs are targeted using…”
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PECAM-1 directed re-targeting of exogenous mRNA providing two orders of magnitude enhancement of vascular delivery and expression in lungs independent of apolipoprotein E-mediated uptake by Parhiz, Hamideh, Shuvaev, Vladimir V., Pardi, Norbert, Khoshnejad, Makan, Kiseleva, Raisa Yu, Brenner, Jacob S., Uhler, Thomas, Tuyishime, Steven, Mui, Barbara L., Tam, Ying K., Madden, Thomas D., Hope, Michael J., Weissman, Drew, Muzykantov, Vladimir R.

“…Systemic administration of lipid nanoparticle (LNP)-encapsulated messenger RNA (mRNA) leads predominantly to hepatic uptake and expression. Here, we conjugated…”
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Selective targeting of nanomedicine to inflamed cerebral vasculature to enhance the blood–brain barrier by Marcos-Contreras, Oscar A., Greineder, Colin F., Kiseleva, Raisa Yu, Parhiz, Hamideh, Walsh, Landis R., Zuluaga-Ramirez, Viviana, Myerson, Jacob W., Hood, Elizabeth D., Villa, Carlos H., Tombacz, Istvan, Pardi, Norbert, Seliga, Alecia, Mui, Barbara L., Tam, Ying K., Glassman, Patrick M., Shuvaev, Vladimir V., Nong, Jia, Brenner, Jacob S., Khoshnejad, Makan, Madden, Tom, Weissmann, Drew, Persidsky, Yuri, Muzykantov, Vladimir R.

“…Drug targeting to inflammatory brain pathologies such as stroke and traumatic brain injury remains an elusive goal. Using a mouse model of acute brain…”
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Added to pre-existing inflammation, mRNA-lipid nanoparticles induce inflammation exacerbation (IE) by Parhiz, Hamideh, Brenner, Jacob S., Patel, Priyal N., Papp, Tyler E., Shahnawaz, Hamna, Li, Qin, Shi, Ruiqi, Zamora, Marco E., Yadegari, Amir, Marcos-Contreras, Oscar A., Natesan, Ambika, Pardi, Norbert, Shuvaev, Vladimir V., Kiseleva, Raisa, Myerson, Jacob W., Uhler, Thomas, Riley, Rachel S., Han, Xuexiang, Mitchell, Michael J., Lam, Kieu, Heyes, James, Weissman, Drew, Muzykantov, Vladimir R.

“…Current nucleoside-modified RNA lipid nanoparticle (modmRNA-LNP) technology has successfully paved the way for the highest clinical efficacy data from…”
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Physiologically based modeling of LNP-mediated delivery of mRNA in the vascular system by Parhiz, Hamideh, Shuvaev, Vladimir V., Li, Qin, Papp, Tyler E., Akyianu, Awurama A., Shi, Ruiqi, Yadegari, Amir, Shahnawaz, Hamna, Semple, Sean C., Mui, Barbara L., Weissman, Drew, Muzykantov, Vladimir R., Glassman, Patrick M.

“…RNA therapeutics are an emerging, powerful class of drugs with potential applications in a wide range of disorders. A central challenge in their development is…”
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1142 mRNA LNP vaccination with the tumor-specific antigen EGFRvIII bolsters CAR T cell activity in vivo by Rodriguez, Jesse L, Papp, Tyler E, Zhang, Logan, Hicks, Kelly A, Parhiz, Hamideh, Binder, Zev, O’Rourke, Donald

“…BackgroundCAR T cell persistence is the only known clinical correlate of activity. Often in solid tumors, CAR T cells fail to persist in patients shortly after…”
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312 IL7 increases targeted lipid nanoparticle-mediated mRNA protein expression in T cells in vitro and in situ by enhancing T cell translation by Tilsed, Caitlin M, Sadiq, Barzan A, Papp, Tyler E, Areesawangkit, Phurin, Noguera-Ortega, Estela, Kimura, Kenji, Cerda, Nicholas, Aghajanian, Haig, Bot, Adrian, Mui, Barbara, Tam, Ying, Weissman, Drew, Albelda, Steven M, Parhiz, Hamideh

“…BackgroundChimeric Antigen Receptor T cells (CARTs) are a powerful anti-cancer therapy, demonstrating success in hematologic malignancies. The development of…”
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The new frontiers of the targeted interventions in the pulmonary vasculature: precision and safety (2017 Grover Conference Series) by Brenner, Jacob S., Kiseleva, Raisa Yu, Glassman, Patrick M., Parhiz, Hamideh, Greineder, Colin F., Hood, Elizabeth D., Shuvaev, Vladimir V., Muzykantov, Vladimir R.

“…The pulmonary vasculature plays an important role in many lung pathologies, such as pulmonary arterial hypertension, primary graft dysfunction of lung…”
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Non-biological gene carriers designed for overcoming the major extra- and intracellular hurdles in gene delivery, an updated review by Hamideh Parhiz, Maryam Hashemi, Mohammad Ramezani

“…Gene therapy as a modern therapeutic approach has not yet advanced to a globally-approved therapeutic approach. Lack of adequate reliable gene delivery system…”
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Antioxidant and Anti‐Inflammatory Properties of the Citrus Flavonoids Hesperidin and Hesperetin: An Updated Review of their Molecular Mechanisms and Experimental Models by Parhiz, Hamideh, Roohbakhsh, Ali, Soltani, Fatemeh, Rezaee, Ramin, Iranshahi, Mehrdad

“…Inflammation and oxidative stress are two major causes of various life‐threatening diseases. Hesperidin (Hsd) and its aglycone, hesperetin (Hst), are two…”
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Gene Transfer Enhancement by Alkylcarboxylation of Poly(propylenimine) by Maryam Hashemi, Hamideh Sahraie Fard, Sara Amel Farzad, Hamideh Parhiz, Mohammad Ramezani

“…Abstract Among synthetic carriers, dendrimers with the more flexible structure have attracted a great deal of researchers’ attention in the field of gene…”
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mRNA-based therapeutics: looking beyond COVID-19 vaccines by Parhiz, Hamideh, Atochina-Vasserman, Elena N, Weissman, Drew

“…Recent advances in mRNA technology and its delivery have enabled mRNA-based therapeutics to enter a new era in medicine. The rapid, potent, and transient…”
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CAR T cells produced in vivo to treat cardiac injury by Rurik, Joel G, Tombácz, István, Yadegari, Amir, Méndez Fernández, Pedro O, Shewale, Swapnil V, Li, Li, Kimura, Toru, Soliman, Ousamah Younoss, Papp, Tyler E, Tam, Ying K, Mui, Barbara L, Albelda, Steven M, Puré, Ellen, June, Carl H, Aghajanian, Haig, Weissman, Drew, Parhiz, Hamideh, Epstein, Jonathan A

“…Fibrosis affects millions of people with cardiac disease. We developed a therapeutic approach to generate transient antifibrotic chimeric antigen receptor…”
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Ferritin-based drug delivery systems: Hybrid nanocarriers for vascular immunotargeting by Khoshnejad, Makan, Parhiz, Hamideh, Shuvaev, Vladimir V., Dmochowski, Ivan J., Muzykantov, Vladimir R.

“…Ferritin subunits of heavy and light polypeptide chains self-assemble into a spherical nanocage that serves as a natural transport vehicle for metals but can…”
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