Search Results - "Pargaonkar, Ashish"
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Elevated dimethylarginine, ATP, cytokines, metabolic remodeling involving tryptophan metabolism and potential microglial inflammation characterize primary open angle glaucoma
Published in Scientific reports (07-05-2021)“…Glaucoma of which primary open angle glaucoma (POAG) constitutes 75%, is the second leading cause of blindness. Elevated intra ocular pressure and Nitric oxide…”
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Adenosine deaminase modulates metabolic remodeling and orchestrates joint destruction in rheumatoid arthritis
Published in Scientific reports (23-07-2021)“…Rheumatoid Arthritis (RA) is a chronic autoimmune disease associated with inflammation and joint remodeling. Adenosine deaminase (ADA), a risk factor in RA,…”
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Integrated multi-omics analysis of Huntington disease identifies pathways that modulate protein aggregation
Published in Disease models & mechanisms (01-10-2022)“…ABSTRACT Huntington disease (HD) is a neurodegenerative disease associated with polyglutamine expansion in the protein huntingtin (HTT). Although the length of…”
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Integrated clinical and metabolomic analysis identifies molecular signatures, biomarkers, and therapeutic targets in primary angle closure glaucoma
Published in Frontiers in molecular biosciences (09-08-2024)“…Glaucoma is the leading cause of permanent blindness. Primary angle closure glaucoma (PACG) is diagnosed only after the onset of symptoms and can result in…”
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Integrated Omic Analysis Delineates Pathways Modulating Toxic TDP-43 Protein Aggregates in Amyotrophic Lateral Sclerosis
Published in Cells (Basel, Switzerland) (24-04-2023)“…Amyotrophic lateral sclerosis (ALS) is a multi-systemic, incurable, amyloid disease affecting the motor neurons, resulting in the death of patients. The…”
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UPLC‐QTOF‐MS analysis of a carbonic anhydrase‐inhibiting extract and fractions of Luffa acutangula (L.) Roxb (ridge gourd)
Published in Phytochemical analysis (01-03-2019)“…Introduction Luffa acutangula (L.) Roxb, commonly known as ridge gourd (cucurbitaceae), is a common vegetable cultivated in India. It is also a well‐used…”
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Metabolic deregulation associated with aging modulates protein aggregation in the yeast model of Huntington's disease
Published in Journal of biomolecular structure & dynamics (02-12-2024)“…Huntington's disease is associated with increased CAG repeat resulting in an expanded polyglutamine tract in the protein Huntingtin (HTT) leading to its…”
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