Search Results - "Parfrey, N. A."

SPG15, a new locus for autosomal recessive complicated HSP on chromosome 14q by HUGHES, C. A, BYRNE, P. C, WEBB, S, MCMONAGLE, P, PATTERSON, V, HUTCHINSON, M, PARFREY, N. A

“…The authors studied two families with autosomal recessive hereditary spastic paraplegia (HSP) complicated by the presence of additional symptoms of pigmented…”
Get full text

Phenotype of AD-HSP due to mutations in the SPAST gene : Comparison with AD-HSP without mutations by MCMONAGLE, P, BYRNE, P. C, FITZGERALD, B, WEBB, S, PARFREY, N. A, HUTCHINSON, M

“…"Pure" autosomal dominant hereditary spastic paraparesis (AD-HSP) is clinically and genetically heterogeneous. There are at least seven genetic loci with…”
Get full text

Age-related cognitive decline in hereditary spastic paraparesis linked to chromosome 2p by BYRNE, P. C, MCMONAGLE, P, WEBB, S, FITZGERALD, B, PARFREY, N. A, HUTCHINSON, M

“…To investigate whether cognitive decline is part of the phenotype of SPG4-linked hereditary spastic paraparesis (HSP) and to determine whether cognitive…”
Get full text

Urokinase-type plasminogen activator and outcome in Dukes' B colorectal cancer by Mulcahy, H E, Duffy, M J, Gibbons, D, McCarthy, P, Parfrey, N A, O'Donoghue, D P, Sheahan, K

“…Urokinase-type plasminogen activator (u-PA) is a serine protease involved in cancer metastasis. Using immunohistochemical methods, we examined the relation…”
Get more information

bcl-2 protein expression is associated with better prognosis in colorectal cancer by LEAHY, D. T, MULCAHY, H. E, O'DONOGHUE, D. P, PARFREY, N. A

“…Aims To investigate the expression of bcl‐2 in colorectal carcinoma and to examine its association with mediators of apoptosis (p53 and mdm‐2),…”
Get full text

Expansion of peripheral blood CD5 + B cells is associated with mild disease in chronic hepatitis C virus infection by Curry, Michael P, Golden-Mason, Lucy, Nolan, Niamh, Parfrey, Nollaig A, Hegarty, John E, O'Farrelly, Cliona

“…Background/Aims: Hepatitis C virus (HCV) infection is associated with the development of chronic liver disease and extra-hepatic manifestations, which include…”
Get full text

Increased major histocompatibility complex antigen expression in unilateral ischemic acute tubular necrosis in the mouse by Shoskes, D A, Parfrey, N A, Halloran, P F

“…In many studies of renal transplant recipients, acute tubular necrosis has been shown to predispose to a higher rate of graft loss, apparently due to…”
Get more information

Localization of the Gene for Autosomal Recessive Congenital Hereditary Endothelial Dystrophy (CHED2) to Chromosome 20 by Homozygosity Mapping by Hand, Collette K., Harmon, Dawn L., Kennedy, Susan M., FitzSimon, J.Susan, Collum, Louis M.T., Parfrey, Nollaig A.

“…Congenital hereditary endothelial dystrophy (CHED) is a corneal disorder that presents with diffuse bilateral corneal clouding. Vision may be severely…”
Get full text

PROGNOSTIC SIGNIFICANCE OF p53 ABNORMALITIES IN COLORECTAL CARCINOMA DETECTED BY PCR-SSCP AND IMMUNOHISTOCHEMICAL ANALYSIS by LEAHY, DERMOT T., SALMAN, REEM, MULCAHY, HUGH, SHEAHAN, KIERAN, O'DONOGHUE, DIARMUID P., PARFREY, NOLLAIG A.

“…Abnormalities in the p53 tumour suppressor gene and in the expression of its protein are common in colorectal carcinoma. The prognostic significance of these…”
Get full text

Homozygosity mapping and linkage analysis demonstrate that autosomal recessive congenital hereditary endothelial dystrophy (CHED) and autosomal dominant CHED are genetically distinct by Callaghan, Máire, Hand, Collette K, Kennedy, Susan M, FitzSimon, J Susan, Collum, Louis M T, Parfrey, Nollaig A

“…BACKGROUND Congenital hereditary endothelial dystrophy (CHED) is a corneal dystrophy characterised by diffuse bilateral corneal clouding resulting in impaired…”
Get full text

Interferon-gamma gene expression during acute graft-versus-host disease: relationship to MHC induction and tissue injury by Parfrey, Nollaig A., El-Sheikh, Amr, Monckton, Elizabeth A., Cockfield, Sandra M., Halloran, Philip F., Linetsky, Elina

“…The pathogenetic role of interferon‐γ (IFN‐γ) in acute graft‐versus‐host disease (GVHD) was examined in a murine model. IFN‐γ gene expression was evaluated by…”
Get full text

Post-transplant lymphoproliferative disorder in renal allograft recipients. Clinical experience and risk factor analysis in a single center by Cockfield, S M, Preiksaitis, J K, Jewell, L D, Parfrey, N A

“…Post-transplant lymphoproliferative disorder (PTLD) is a well-recognized complication of solid organ transplantation. The University of Alberta Renal…”
Get more information

Cyclosporine-induced autoimmunity and immune hyperreactivity by Prud'homme, G J, Parfrey, N A, Vanier, L E

“…Cyclosporine (CS) is a potent immunosuppressive agent which under some circumstances paradoxically augments DTH responses, aggravates some autoimmune diseases,…”
Get more information

Role of T helper lymphocytes in autoimmune diseases by Prud'homme, G J, Parfrey, N A

Get more information

Interferon gamma-mediated renal MHC expression in mercuric chloride-induced glomerulonephritis by Madrenas, Joaquin, Parfrey, Nollaig A., Halloran, Philip F.

“…Interferon gamma-mediated renal MHC expression in mercuric chloride-induced glomerulonephritis. In rodents, mercuric chloride (HgCl2) causes an autoimmune…”
Get full text

Patterns of MHC antigenic modulation in cyclosporine-induced autoimmunity. Implications for pathogenesis by Parfrey, NA, Prud'homme, GJ

“…To explore the role of aberrant MHC expression in the pathogenesis of cyclosporine-induced autoimmunity (CSIA), we examined the patterns of major…”
Get full text

Evidence that nonlymphoid tissue injury in acute graft-versus-host disease is limited to epithelial cells aberrantly expressing MHC antigens by Parfrey, N A, Ste-Croix, H, Prud'Homme, G J

“…To explore the relationship between aberrant MHC antigen expression and tissue injury in acute graft-versus-host disease, we performed a sequential…”
Get more information

The decreased incidence of aseptic necrosis in renal transplant recipients--a case control study by Parfrey, P S, Farge, D, Parfrey, N A, Hanley, J A, Guttman, R D

“…Before 1971 the incidence of aseptic necrosis in renal transplant recipients was 29%, and after 1971 it was 5%. To investigate the reasons for this decreased…”
Get more information

Dendritic cell-lymphoid cell aggregation and major histocompatibility antigen expression during rat cardiac allograft rejection by FORBES, R. D. C, PARFREY, N. A, GOMERSALL, M, DARDEN, A. G, GUTTMANN, R. D

“…To determine the pattern of cellular expression of donor MHC class I and class II antigens during the course of rat cardiac allograft rejection, ACI cardiac…”
Get full text

Thymus-independent expression of a truncated T cell receptor-alpha mRNA in murine kidney by Madrenas, J, Pazderka, F, Parfrey, NA, Halloran, PF

“…During studies on gene expression in the kidney, we unexpectedly observed that murine kidney expresses a truncated form of TCR-alpha mRNA (1.3-1.4 kb). This…”
Get full text