Search Results - "Parfitt, A Michael"

Standardized nomenclature, symbols, and units for bone histomorphometry: A 2012 update of the report of the ASBMR Histomorphometry Nomenclature Committee by Dempster, David W, Compston, Juliet E, Drezner, Marc K, Glorieux, Francis H, Kanis, John A, Malluche, Hartmut, Meunier, Pierre J, Ott, Susan M, Recker, Robert R, Parfitt, A Michael

“…Before publication of the original version of this report in 1987, practitioners of bone histomorphometry communicated with each other in a variety of arcane…”
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Skeletal Involution by Age-associated Oxidative Stress and Its Acceleration by Loss of Sex Steroids by Almeida, Maria, Han, Li, Martin-Millan, Marta, Plotkin, Lilian I., Stewart, Scott A., Roberson, Paula K., Kousteni, Stavroula, O'Brien, Charles A., Bellido, Teresita, Parfitt, A. Michael, Weinstein, Robert S., Jilka, Robert L., Manolagas, Stavros C.

“…Both aging and loss of sex steroids have adverse effects on skeletal homeostasis, but whether and how they may influence each others negative impact on bone…”
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A new approach to iliac bone histomorphometry: implications for biomechanics and cell biology by Parfitt, A Michael

“…I devised a method for obtaining information on cancellous bone structure from iliac bone histomorphometry that led to the demonstration that architecture is…”
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Osteocyte Apoptosis Is Induced by Weightlessness in Mice and Precedes Osteoclast Recruitment and Bone Loss by Aguirre, J Ignacio, Plotkin, Lilian I, Stewart, Scott A, Weinstein, Robert S, Parfitt, A Michael, Manolagas, Stavros C, Bellido, Teresita

“…Mechanical stimulation of cultured osteocytic cells attenuates their apoptosis. We report here that, conversely, reduced mechanical forces in the murine model…”
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Promotion of osteoclast survival and antagonism of bisphosphonate-induced osteoclast apoptosis by glucocorticoids by Weinstein, Robert S, Chen, Jin-Ran, Powers, Cara C, Stewart, Scott A, Landes, Reid D, Bellido, Teresita, Jilka, Robert L, Parfitt, A Michael, Manolagas, Stavros C

“…Glucocorticoids depress bone formation by inhibiting osteoblastogenesis and increasing osteoblast apoptosis. However, the role of bone resorption in the…”
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The morphological association between microcracks and osteocyte lacunae in human cortical bone by Qiu, Shijing, Sudhaker Rao, D., Fyhrie, David P., Palnitkar, Saroj, Parfitt, A. Michael

“…We studied the spatial relationship between the osteocyte lacunar–canalicular network and microdamage accumulation in bone matrix. Rib sections from 9 white…”
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Renal bone disease: a new conceptual framework for the interpretation of bone histomorphometry by Parfitt, A Michael

“…My purpose in this article is to restore the histologic appraisal of renal bone disease to the mainstream of bone and mineral metabolism from which it has been…”
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Misconceptions V—Activation of osteoclasts is the first step in the bone remodeling cycle by Michael Parfitt, A.

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What old means to bone by Manolagas, Stavros C, Parfitt, A. Michael

“…The adverse effects of aging of other organs (ovaries at menopause) on the skeleton are well known, but ironically little is known of skeletal aging itself…”
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High Bone Turnover Is Intrinsically Harmful: Two Paths to a Similar Conclusion: The Parfitt View by Parfitt, A. Michael

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Bone loss and bone turnover in diabetes by KRAKAUER, J. C, MCKENNA, M. J, BUDERER, N. F, SUDHAKER RAO, D, WHITEHOUSE, F. W, PARFITT, A. M

“…There have been conflicting reports about the effect of diabetes on bone density. In 1978, we studied 109 patients, 46 with type I and 63 with type II…”
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For whom the bell tolls: Distress signals from long-lived osteocytes and the pathogenesis of metabolic bone diseases by Manolagas, Stavros C, Parfitt, A. Michael

“…Abstract Osteocytes are long-lived and far more numerous than the short-lived osteoblasts and osteoclasts. Immured within the lacunar–canalicular system and…”
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Effects of raloxifene, hormone replacement therapy, and placebo on bone turnover in postmenopausal women by WEINSTEIN, Robert S, PARFITT, A. Michael, MARCUS, Robert, GREENWALD, Maria, CRANS, Gerald, MUCHMORE, Douglas B

“…Raloxifene, a nonsteroidal selective estrogen receptor modulator (SERM), increases bone mineral density (BMD), decreases biochemical markers of bone turnover,…”
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The Skeletal Effects of Glucocorticoid Excess Override Those of Orchidectomy in Mice by Weinstein, Robert S, Jia, Dan, Powers, Cara C, Stewart, Scott A, Jilka, Robert L, Parfitt, A. Michael, Manolagas, Stavros C

“…Hypogonadism has been implicated as a contributing factor in glucocorticoid-induced osteoporosis, but evidence for this is limited. Hypogonadism and…”
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The Effects of Androgen Deficiency on Murine Bone Remodeling and Bone Mineral Density Are Mediated via Cells of the Osteoblastic Lineage by Weinstein, Robert S., Jilka, Robert L., Parfitt, A. Michael, Manolagas, Stavros C.

“…Abstract Both estrogens and androgens act on bone marrow stromal/osteoblastic cells to inhibit the production of local factors that promote osteoclast…”
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Drugs Used to Treat Osteoporosis: The Critical Need for a Uniform Nomenclature Based on Their Action on Bone Remodeling by Riggs, B Lawrence, Parfitt, A Michael

“…There continues to be uncertainty about the classification of available drugs for treating osteoporosis. We find that grouping them into anti‐catabolic and…”
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Quantifying osteoblast and osteocyte apoptosis : Challenges and rewards by JILKA, Robert L, WEINSTEIN, Robert S, PARFITT, A. Michael, MANOLAGAS, Stavros C

“…Since the initial demonstration of the phenomenon in murine and human bone sections approximately 10 yr ago, appreciation of the biologic significance of…”
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Rosiglitazone Causes Bone Loss in Mice by Suppressing Osteoblast Differentiation and Bone Formation by Ali, A. Afshan, Weinstein, Robert S, Stewart, Scott A, Parfitt, A. Michael, Manolagas, Stavros C, Jilka, Robert L

“…Because osteoblasts and marrow adipocytes are derived from a common mesenchymal progenitor, increased adipogenesis may occur at the expense of osteoblasts,…”
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Parathyroid Hormone and Periosteal Bone Expansion by Parfitt, A. Michael

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Prevention of osteocyte and osteoblast apoptosis by bisphosphonates and calcitonin by Plotkin, L I, Weinstein, R S, Parfitt, A M, Roberson, P K, Manolagas, S C, Bellido, T

“…Glucocorticoid-induced osteoporosis may be due, in part, to increased apoptosis of osteocytes and osteoblasts, and bisphosphonates (BPs) are effective in the…”
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