Search Results - "Paresh C. Sanghani"

Human carboxylesterases: an update on CES1, CES2 and CES3 by Sanghani, Sonal P, Sanghani, Paresh C, Schiel, Marissa A, Bosron, William F

“…Carboxylesterases belong to Phase I group of drug metabolizing enzymes. They hydrolyze a variety of drug esters, amides, carbamates and similar structures…”
Get more information

Kinetic and Cellular Characterization of Novel Inhibitors of S-Nitrosoglutathione Reductase by Sanghani, Paresh C., Davis, Wilhelmina I., Fears, Sharry L., Green, Scheri-Lyn, Zhai, Lanmin, Tang, Yaoping, Martin, Emil, Bryan, Nathan S., Sanghani, Sonal P.

“…S-Nitrosoglutathione reductase (GSNOR) is an alcohol dehydrogenase involved in the regulation of S-nitrosothiols (SNOs) in vivo. Knock-out studies in mice have…”
Get full text

A multiple reaction monitoring method for absolute quantification of the human liver alcohol dehydrogenase ADH1C1 isoenzyme by Janecki, Dariusz J., Bemis, Kerry G., Tegeler, Tony J., Sanghani, Paresh C., Zhai, Lanmin, Hurley, Thomas D., Bosron, William F., Wang, Mu

“…Although significant progress has been made in protein quantification using mass spectrometry during recent years, absolute protein quantification in complex…”
Get full text

Expression and characterization of a human carboxylesterase 2 splice variant by Schiel, Marissa A, Green, Scheri-lyn, Davis, Wilhelmina I, Sanghani, Paresh C, Bosron, William F, Sanghani, Sonal P

“…CPT-11 [7-ethyl-10-[4-(1-piperidino)-1-piperidino] carbonyloxycamptothecin or Irinotecan] is a carbamate prodrug that is activated in vivo by carboxylesterase…”
Get more information

Kinetic Mechanism of Human Glutathione-Dependent Formaldehyde Dehydrogenase by Sanghani, Paresh C, Stone, Carol L, Ray, Bruce D, Pindel, Evgenia V, Hurley, Thomas D, Bosron, William F

“…Formaldehyde, a major industrial chemical, is classified as a carcinogen because of its high reactivity with DNA. It is inactivated by oxidative metabolism to…”
Get full text

Ethanol Metabolism by HeLa Cells Transduced With Human Alcohol Dehydrogenase Isoenzymes: Control of the Pathway by Acetaldehyde Concentration by Matsumoto, Michinaga, Cyganek, Izabela, Sanghani, Paresh C., Cho, Won Kyoo, Liangpunsakul, Suthat, Crabb, David W.

“…Background:  Human class I alcohol dehydrogenase 2 isoenzymes (encoded by the ADH1B locus) have large differences in kinetic properties; however, individuals…”
Get full text

Human Glutathione-Dependent Formaldehyde Dehydrogenase. Structures of Apo, Binary, and Inhibitory Ternary Complexes by Sanghani, Paresh C, Robinson, Howard, Bosron, William F, Hurley, Thomas D

“…The human glutathione-dependent formaldehyde dehydrogenase is unique among the structurally studied members of the alcohol dehydrogenase family in that it…”
Get full text

Assay of the pyruvate dehydrogenase complex by coupling with recombinant chicken liver arylamine N-acetyltransferase by Jeoung, Nam Ho, Sanghani, Paresh C., Zhai, Lanmin, Harris, Robert A.

“…The activity of the pyruvate dehydrogenase complex has long been determined in some laboratories by coupling the production of acetyl-coenzyme A (acetyl-CoA)…”
Get full text

Structure−Function Relationships in Human Glutathione-Dependent Formaldehyde Dehydrogenase. Role of Glu-67 and Arg-368 in the Catalytic Mechanism by Sanghani, Paresh C, Davis, Wilhelmina I, Zhai, LanMin, Robinson, Howard

“…The active-site zinc in human glutathione-dependent formaldehyde dehydrogenase (FDH) undergoes coenzyme-induced displacement and transient coordination to a…”
Get full text

Human Glutathione-Dependent Formaldehyde Dehydrogenase. Structural Changes Associated with Ternary Complex Formation by Sanghani, Paresh C, Bosron, William F, Hurley, Thomas D

“…Human glutathione-dependent formaldehyde dehydrogenase plays an important role in the metabolism of glutathione adducts such as S-(hydroxymethyl)glutathione…”
Get full text

Structure–function relationships in human Class III alcohol dehydrogenase (formaldehyde dehydrogenase) by Sanghani, Paresh C., Robinson, Howard, Bennett-Lovsey, Riccardo, Hurley, Thomas D., Bosron, W.F.

“…Human Class III alcohol dehydrogenase (ADH), also known as glutathione-dependent formaldehyde dehydrogenase plays an important role in the formaldehyde…”
Get full text

Ethanol Metabolism by HeLa Cells Transduced With Human Alcohol Dehydrogenase Isoenzymes: Control of the Pathway by Acetaldehyde Concentration: ETHANOL METABOLISM BY CELLS EXPRESSING β ADH by Matsumoto, Michinaga, Cyganek, Izabela, Sanghani, Paresh C., Cho, Won Kyoo, Liangpunsakul, Suthat, Crabb, David W.

Get full text

Identification of Three Key Active Site Residues in the C-terminal Domain of Human Recombinant Folylpoly-γ-glutamate Synthetase by Site-directed Mutagenesis by Sonal P. Sanghani, Paresh C. Sanghani, Richard G. Moran

“…Three cysteines in human recombinant folylpoly-γ-glutamate synthetase (FPGS) that were reactive with iodoacetamide were located in peptides that were highly…”
Get full text

Identification of Three Key Active Site Residues in the C-terminal Domain of Human Recombinant Folylpoly-γ-glutamate Synthetase by Site-directed Mutagenesis by Sanghani, Sonal P., Sanghani, Paresh C., Moran, Richard G.

“…Three cysteines in human recombinant folylpoly-γ-glutamate synthetase (FPGS) that were reactive with iodoacetamide were located in peptides that were highly…”
Get full text

Purification and Characteristics of Recombinant Human Folylpoly-γ-glutamate Synthetase Expressed at High Levels in Insect Cells by Sanghani, Paresh C., Moran, Richard G.

“…Folylpoly-γ-glutamate synthetase activity is central to the operation of folate metabolism and is essential for the survival of mammalian stem cell populations…”
Get full text