Search Results - "Parent, Leslie J"

SARS-CoV-2 vaccine effectiveness against infection, symptomatic and severe COVID-19: a systematic review and meta-analysis by Ssentongo, Paddy, Ssentongo, Anna E, Voleti, Navya, Groff, Destin, Sun, Ashley, Ba, Djibril M, Nunez, Jonathan, Parent, Leslie J, Chinchilli, Vernon M, Paules, Catharine I

“…The temporal evolution of SARS-CoV-2 vaccine efficacy and effectiveness (VE) against infection, symptomatic, and severe COVID-19 is incompletely defined. The…”
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Liquid-liquid phase separation of nucleocapsid proteins during SARS-CoV-2 and HIV-1 replication by Chau, Bao-An, Chen, Venessa, Cochrane, Alan W., Parent, Leslie J., Mouland, Andrew J.

“…The leap of retroviruses and coronaviruses from animal hosts to humans has led to two ongoing pandemics and tens of millions of deaths worldwide. Retrovirus…”
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Comparative analysis of retroviral Gag-host cell interactions: focus on the nuclear interactome by Lambert, Gregory S, Rice, Breanna L, Maldonado, Rebecca J Kaddis, Chang, Jordan, Parent, Leslie J

“…Retroviruses exploit host proteins to assemble and release virions from infected cells. Previously, most studies focused on interacting partners of retroviral…”
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Distinct binding interactions of HIV-1 Gag to Psi and non-Psi RNAs: implications for viral genomic RNA packaging by Webb, Joseph A, Jones, Christopher P, Parent, Leslie J, Rouzina, Ioulia, Musier-Forsyth, Karin

“…Despite the vast excess of cellular RNAs, precisely two copies of viral genomic RNA (gRNA) are selectively packaged into new human immunodeficiency type 1…”
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HIV-1 Gag Forms Ribonucleoprotein Complexes with Unspliced Viral RNA at Transcription Sites by Tuffy, Kevin M, Maldonado, Rebecca J Kaddis, Chang, Jordan, Rosenfeld, Paul, Cochrane, Alan, Parent, Leslie J

“…The ability of the retroviral Gag protein of Rous sarcoma virus (RSV) to transiently traffic through the nucleus is well-established and has been implicated in…”
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Opposing roles of CLK SR kinases in controlling HIV-1 gene expression and latency by Dahal, Subha, Clayton, Kiera, Been, Terek, Fernet-Brochu, Raphaële, Ocando, Alonso Villasmil, Balachandran, Ahalya, Poirier, Mikaël, Maldonado, Rebecca Kaddis, Shkreta, Lulzim, Boligan, Kayluz Frias, Guvenc, Furkan, Rahman, Fariha, Branch, Donald, Bell, Brendan, Chabot, Benoit, Gray-Owen, Scott D, Parent, Leslie J, Cochrane, Alan

“…The generation of over 69 spliced HIV-1 mRNAs from one primary transcript by alternative RNA splicing emphasizes the central role that RNA processing plays in…”
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Orchestrating the Selection and Packaging of Genomic RNA by Retroviruses: An Ensemble of Viral and Host Factors by Kaddis Maldonado, Rebecca J, Parent, Leslie J

“…Infectious retrovirus particles contain two copies of unspliced viral RNA that serve as the viral genome. Unspliced retroviral RNA is transcribed in the…”
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Visualizing Association of the Retroviral Gag Protein with Unspliced Viral RNA in the Nucleus by Maldonado, Rebecca J Kaddis, Rice, Breanna, Chen, Eunice C, Tuffy, Kevin M, Chiari, Estelle F, Fahrbach, Kelly M, Hope, Thomas J, Parent, Leslie J

“…Packaging of genomic RNA (gRNA) by retroviruses is essential for infectivity, yet the subcellular site of the initial interaction between the Gag polyprotein…”
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Visualizing Rous Sarcoma Virus Genomic RNA Dimerization in the Nucleus, Cytoplasm, and at the Plasma Membrane by Chen, Eunice C., Maldonado, Rebecca J. Kaddis, Parent, Leslie J.

“…Retroviruses are unique in that they package their RNA genomes as non-covalently linked dimers. Failure to dimerize their genomes results in decreased…”
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RNA-Binding Domains of Heterologous Viral Proteins Substituted for Basic Residues in the RSV Gag NC Domain Restore Specific Packaging of Genomic RNA by Rice, Breanna L, Lochmann, Timothy L, Parent, Leslie J

“…The Rous sarcoma virus Gag polyprotein transiently traffics through the nucleus, which is required for efficient incorporation of the viral genomic RNA (gRNA)…”
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Genetic Evidence for a Connection between Rous Sarcoma Virus Gag Nuclear Trafficking and Genomic RNA Packaging by GARBITT-HIRST, Rachel, KENNEY, Scott P, PARENT, Leslie J

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Directionality of nucleocytoplasmic transport of the retroviral gag protein depends on sequential binding of karyopherins and viral RNA by Gudleski, Nicole, Flanagan, John M, Ryan, Eileen P, Bewley, Maria C, Parent, Leslie J

“…Retroviral Gag polyproteins coopt host factors to traffic from cytosolic ribosomes to the plasma membrane, where virions are released. Before membrane…”
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Rous Sarcoma Virus Genomic RNA Dimerization Capability In Vitro Is Not a Prerequisite for Viral Infectivity by Liu, Shuohui, Kaddis Maldonado, Rebecca, Rye-McCurdy, Tiffiny, Binkley, Christiana, Bah, Aissatou, Chen, Eunice C, Rice, Breanna L, Parent, Leslie J, Musier-Forsyth, Karin

“…Retroviruses package their full-length, dimeric genomic RNA (gRNA) via specific interactions between the Gag polyprotein and a "Ψ" packaging signal located in…”
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Alterations in the MA and NC Domains Modulate Phosphoinositide-Dependent Plasma Membrane Localization of the Rous Sarcoma Virus Gag Protein by Nadaraia-Hoke, Shorena, Bann, Darrin V., Lochmann, Timothy L., Gudleski-O'Regan, Nicole, Parent, Leslie J.

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Nucleolar Trafficking of the Mouse Mammary Tumor Virus Gag Protein Induced by Interaction with Ribosomal Protein L9 by Beyer, Andrea R, Bann, Darrin V, Rice, Breanna, Pultz, Ingrid S, Kane, Melissa, Goff, Stephen P, Golovkina, Tatyana V, Parent, Leslie J

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New insights into the nuclear localization of retroviral gag proteins by Parent, Leslie J.

“…  Retroviruses assemble new virus particles that are released by budding from the plasma membranes of infected cells. Gag proteins, encoded by retroviruses,…”
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Monoclonal Antibodies to S and N SARS-CoV-2 Proteins as Probes to Assess Structural and Antigenic Properties of Coronaviruses by Kumar, Rinki, Christensen, Neil D, Kaddis Maldonado, Rebecca J, Bewley, Maria C, Ostman, Alexandria, Sudol, Malgorzata, Chen, Eunice C, Buchkovich, Natalie W, Gontu, Abhinay, Surendran Nair, Meera, Nissly, Ruth H, Minns, Allen M, Kapur, Vivek, Rossi, Randall, Kuchipudi, Suresh V, Lindner, Scott E, Parent, Leslie J, Flanagan, John M, Buchkovich, Nicholas J

“…Antibodies targeting the spike (S) and nucleocapsid (N) proteins of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are essential tools. In…”
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HIV-1 Gag co-localizes with euchromatin histone marks at the nuclear periphery by Chang, Jordan, Parent, Leslie J

“…The traditional view of retrovirus assembly posits that packaging of gRNA by HIV-1 Gag occurs in the cytoplasm or at the plasma membrane. However, our previous…”
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Functional Equivalence of Retroviral MA Domains in Facilitating Psi RNA Binding Specificity by Gag by Rye-McCurdy, Tiffiny, Olson, Erik D, Liu, Shuohui, Binkley, Christiana, Reyes, Joshua-Paolo, Thompson, Brian R, Flanagan, John M, Parent, Leslie J, Musier-Forsyth, Karin

“…Retroviruses specifically package full-length, dimeric genomic RNA (gRNA) even in the presence of a vast excess of cellular RNA. The "psi" (Ψ) element within…”
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Application of live-cell RNA imaging techniques to the study of retroviral RNA trafficking by Bann, Darrin V, Parent, Leslie J

“…Retroviruses produce full-length RNA that serves both as a genomic RNA (gRNA), which is encapsidated into virus particles, and as an mRNA, which directs the…”
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