Search Results - "Parent, Angèle T"

APP Receptor? To Be or Not To Be by Deyts, Carole, Thinakaran, Gopal, Parent, Angèle T

“…Amyloid precursor protein (APP) and its metabolites play a key role in Alzheimer's disease pathogenesis. The idea that APP may function as a receptor has…”
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A Function for EHD Family Proteins in Unidirectional Retrograde Dendritic Transport of BACE1 and Alzheimer’s Disease Aβ Production by Buggia-Prévot, Virginie, Fernandez, Celia G., Udayar, Vinod, Vetrivel, Kulandaivelu S., Elie, Aureliane, Roseman, Jelita, Sasse, Verena A., Lefkow, Margaret, Meckler, Xavier, Bhattacharyya, Sohinee, George, Manju, Kar, Satyabrata, Bindokas, Vytautas P., Parent, Angèle T., Rajendran, Lawrence, Band, Hamid, Vassar, Robert, Thinakaran, Gopal

“…Abnormal accumulation of β-secretase (BACE1) in dystrophic neurites and presynaptic β-amyloid (Aβ) production contribute to Alzheimer's disease pathogenesis…”
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Transgenic neuronal overexpression reveals that stringently regulated p23 expression is critical for coordinated movement in mice by Gong, Ping, Roseman, Jelita, Fernandez, Celia G, Vetrivel, Kulandaivelu S, Bindokas, Vytautas P, Zitzow, Lois A, Kar, Satyabrata, Parent, Angèle T, Thinakaran, Gopal

“…p23 belongs to the highly conserved p24 family of type I transmembrane proteins, which participate in the bidirectional protein transport between the…”
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Modeling Presenilin-Dependent Familial Alzheimer's Disease : Emphasis on Presenilin Substrate-Mediated Signaling and Synaptic Function by Parent, Angèle T., Thinakaran, Gopal

“…Mutations in PSEN genes, which encode presenilin proteins, cause familial early-onset Alzheimer's disease (AD). Transgenic mouse models based on coexpression…”
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Steady-state increase of cAMP-response element binding protein, Rac, and PAK signaling in presenilin-deficient neurons by Barnes, Natalie Y, Shi, Jun, Yajima, Hiroshi, Thinakaran, Gopal, Parent, Angèle T

“…Mutations in the genes encoding presenilins (PS1 and PS2) account for the majority of cases of early-onset Alzheimer's disease. PS1 and PS2 form the catalytic…”
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Loss of presenilin function is associated with a selective gain of APP function by Deyts, Carole, Clutter, Mary, Herrera, Stacy, Jovanovic, Natalia, Goddi, Anna, Parent, Angèle T

“…Presenilin 1 (PS1) is an essential γ-secretase component, the enzyme responsible for amyloid precursor protein (APP) intramembraneous cleavage. Mutations in…”
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Lack of BACE1 S-palmitoylation reduces amyloid burden and mitigates memory deficits in transgenic mouse models of Alzheimer’s disease by Andrew, Robert J., Fernandez, Celia G., Stanley, Molly, Jiang, Hong, Nguyen, Phuong, Rice, Richard C., Buggia-Prévot, Virginie, De Rossi, Pierre, Vetrivel, Kulandaivelu S., Lamb, Raza, Argemi, Arnau, Allaert, Emilie S., Rathbun, Elle M., Krause, Sofia V., Wagner, Steven L., Parent, Angèle T., Holtzman, David M., Thinakaran, Gopal

“…Alzheimer’s disease (AD) is a devastating neurodegenerative disorder characterized by pathological brain lesions and a decline in cognitive function. β-Amyloid…”
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APP-Mediated Signaling Prevents Memory Decline in Alzheimer’s Disease Mouse Model by Deyts, Carole, Clutter, Mary, Pierce, Nicholas, Chakrabarty, Paramita, Ladd, Thomas B., Goddi, Anna, Rosario, Awilda M., Cruz, Pedro, Vetrivel, Kulandaivelu, Wagner, Steven L., Thinakaran, Gopal, Golde, Todd E., Parent, Angèle T.

“…Amyloid precursor protein (APP) and its metabolites play key roles in Alzheimer’s disease (AD) pathophysiology. Whereas short amyloid-β (Aβ) peptides derived…”
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Spatial segregation of gamma-secretase and substrates in distinct membrane domains by Vetrivel, Kulandaivelu S, Cheng, Haipeng, Kim, Seong-Hun, Chen, Ying, Barnes, Natalie Y, Parent, Angèle T, Sisodia, Sangram S, Thinakaran, Gopal

“…Gamma-secretase facilitates the regulated intramembrane proteolysis of select type I membrane proteins that play diverse physiological roles in multiple cell…”
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Novel GαS-protein signaling associated with membrane-tethered amyloid precursor protein intracellular domain by Deyts, Carole, Vetrivel, Kulandaivelu S, Das, Shibandri, Shepherd, Yumiko M, Dupré, Denis J, Thinakaran, Gopal, Parent, Angèle T

“…Numerous physiological functions, including a role as a cell surface receptor, have been ascribed to Alzheimer's disease-associated amyloid precursor protein…”
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D-Serine Is an Endogenous Ligand for the Glycine Site of the N-Methyl-D-Aspartate Receptor by Mothet, Jean-Pierre, Parent, Angele T., Wolosker, Herman, Brady, Roscoe O., Linden, David J., Ferris, Christopher D., Rogawski, Michael A., Snyder, Solomon H.

“…Functional activity of N-methyl-D-aspartate (NMDA) receptors requires both glutamate binding and the binding of an endogenous coagonist that has been presumed…”
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Mutation Analysis of the Presenilin 1 N-terminal Domain Reveals a Broad Spectrum of γ-Secretase Activity toward Amyloid Precursor Protein and Other Substrates by Gong, Ping, Vetrivel, Kulandaivelu S., Nguyen, Phuong D., Meckler, Xavier, Cheng, Haipeng, Kounnas, Maria Z., Wagner, Steven L., Parent, Angèle T., Thinakaran, Gopal

“…The γ-secretase protein complex executes the intramembrane proteolysis of amyloid precursor protein (APP), which releases Alzheimer disease β-amyloid peptide…”
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Reduced Alzheimer's Disease β-Amyloid Deposition in Transgenic Mice Expressing S -Palmitoylation-Deficient APH1aL and Nicastrin by Meckler, Xavier, Roseman, Jelita, Das, Pritam, Cheng, Haipeng, Pei, Susan, Keat, Marcia, Kassarjian, Breanne, Golde, Todd E., Parent, Angèle T., Thinakaran, Gopal

“…Sequential cleavage of amyloid precursor protein by β- and γ-secretases generates β-amyloid peptides (Aβ), which accumulate in the brains of patients with…”
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Identification of the role of presenilins beyond Alzheimer’s disease by Thinakaran, Gopal, Parent, Angèle T

“…Mutations in the genes encoding presenilin 1 (PS1) and presenilin 2 (PS2) account for the majority of the cases of familial early-onset Alzheimer’s disease…”
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Evidence That CD147 Modulation of β-Amyloid (Aβ) Levels Is Mediated by Extracellular Degradation of Secreted Aβ by Vetrivel, Kulandaivelu S., Zhang, Xulun, Meckler, Xavier, Cheng, Haipeng, Lee, Sungho, Gong, Ping, Lopes, Kryslaine O., Chen, Ying, Iwata, Nobuhisa, Yin, Ke-Jie, Lee, Jin-Moo, Parent, Angèle T., Saido, Takaomi C., Li, Yue-Ming, Sisodia, Sangram S., Thinakaran, Gopal

“…Cerebral deposition of β-amyloid (Aβ) peptides is a pathological hallmark of Alzheimer disease. Intramembranous proteolysis of amyloid precursor protein by a…”
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Localization and regional distribution of p23/TMP21 in the brain by Vetrivel, Kulandaivelu S, Kodam, Anitha, Gong, Ping, Chen, Ying, Parent, Angèle T, Kar, Satyabrata, Thinakaran, Gopal

“…Abstract Sequential processing of amyloid precursor protein by β- and γ-secretases generates Alzheimer's disease (AD)-associated β-amyloid peptides. Recently…”
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Presenilin Attenuates Receptor-Mediated Signaling and Synaptic Function by Parent, Angele T, Barnes, Natalie Y, Taniguchi, Yoshihito, Thinakaran, Gopal, Sisodia, Sangram S

“…Presenilin (PS) plays an essential role in intramembranous gamma-secretase processing of amyloid precursor protein (APP) and several membrane-bound proteins…”
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Stringently regulated p23 expression is critical for coordinated movement in mice: implications for Alzheimer’s disease by Gong, Ping, Roseman, Jelita, Vetrivel, Kulandaivelu S, Bindokas, Vytautas P, Zitzow, Lois A, Kar, Satyabrata, Parent, Angèle T, Thinakaran, Gopal

“…The neurological phenotype observed in Hup23 mice has significant implications for translational Alzheimer's disease research aimed at stimulating p23…”
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Regulation of dynamic BACE1 trafficking in neurons by Buggia-Prévot, Virginie, Fernandez, Celia G, Riordan, Sean, Vetrivel, Kulandaivelu S, Udayar, Vinod, Elie, Aureliane, Lefkow, Margaret, Roseman, Jelita, Meckler, Xavier, Bhattacharyya, Sohinee, George, Manju, Waters, Jack, Bindokas, Vytautas P, Parent, Angèle T, Rajendran, Lawrence, Band, Hamid, Vassar, Robert, Thinakaran, Gopal

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Evidence that CD147 modulation of beta-amyloid (Abeta) levels is mediated by extracellular degradation of secreted Abeta by Vetrivel, Kulandaivelu S, Zhang, Xulun, Meckler, Xavier, Cheng, Haipeng, Lee, Sungho, Gong, Ping, Lopes, Kryslaine O, Chen, Ying, Iwata, Nobuhisa, Yin, Ke-Jie, Lee, Jin-Moo, Parent, Angèle T, Saido, Takaomi C, Li, Yue-Ming, Sisodia, Sangram S, Thinakaran, Gopal

“…Cerebral deposition of beta-amyloid (Abeta) peptides is a pathological hallmark of Alzheimer disease. Intramembranous proteolysis of amyloid precursor protein…”
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