Search Results - "Parelkar, Nikhil K"

Modulation of D2R-NR2B Interactions in Response to Cocaine by Liu, Xian-Yu, Chu, Xiang-Ping, Mao, Li-Min, Wang, Min, Lan, Hong-Xiang, Li, Ming-Hua, Zhang, Guo-Chi, Parelkar, Nikhil K., Fibuch, Eugene E., Haines, Michelle, Neve, Kim A., Liu, Fang, Xiong, Zhi-Gang, Wang, John Q.

“…Dopamine-glutamate interactions in the neostriatum determine psychostimulant action, but the underlying molecular mechanisms remain elusive. Here we found that…”
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In vivo regulation of Homer1a expression in the striatum by cocaine by Zhang, Guo-Chi, Mao, Li-Min, Liu, Xian-Yu, Parelkar, Nikhil K, Arora, Anish, Yang, Lu, Hains, Michelle, Fibuch, Eugene E, Wang, John Q

“…The glutamate receptor adaptor protein Homer is concentrated in the postsynaptic density of excitatory synapses and is critical for normal operation of…”
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Phosphorylation of AMPA receptors: mechanisms and synaptic plasticity by Wang, John Q, Arora, Anish, Yang, Lu, Parelkar, Nikhil K, Zhang, Guochi, Liu, Xianyu, Choe, Eun Sang, Mao, Limin

“…The ionotropic alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) receptor is densely distributed in the mammalian brain and is primarily involved…”
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Upregulation of metabotropic glutamate receptor 8 mRNA expression in the rat forebrain after repeated amphetamine administration by Parelkar, Nikhil K., Wang, John Q.

“…Metabotropic glutamate receptors (mGluRs) are G-protein-coupled receptors and are densely expressed in the forebrain of adult rats. Accumulative evidence…”
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Phosphorylation of glutamate receptors: A potential mechanism for the regulation of receptor function and psychostimulant action by Wang, John Q., Liu, Xianyu, Zhang, Guochi, Parelkar, Nikhil K., Arora, Anish, Haines, Michelle, Fibuch, Eugene E., Mao, Limin

“…Ionotropic glutamate receptors, N‐methyl‐d‐aspartate receptors (NMDARs) and α‐amino‐3‐hydroxy‐5‐methylisoxazole‐4‐propionic acid receptors (AMPARs), are…”
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PPARα-Independent Arterial Smooth Muscle Relaxant Effects of PPARα Agonists by Badr, Mostafa Z., Parelkar, Nikhil K., Wacker, Michael J., Andresen, Jon, Silswal, Neerupma

“…We sought to determine direct vascular effects of peroxisome proliferator-activated receptor alpha (PPARα) agonists using isolated mouse aortas and middle…”
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The protein phosphatase 1/2A inhibitor okadaic acid increases CREB and Elk‐1 phosphorylation and c‐fos expression in the rat striatum in vivo by Choe, Eun Sang, Parelkar, Nikhil K., Kim, Jong Yeon, Cho, Hyun Wook, Kang, Ho Sung, Mao, Limin, Wang, John Q.

“…Activation of group I metabotropic glutamate receptors (mGluRs) up‐regulates transcription factor cyclic AMP response element‐binding protein (CREB) and Elk‐1…”
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Protein Kinase A–Phosphorylated KV1 Channels in PSD95 Signaling Complex Contribute to the Resting Membrane Potential and Diameter of Cerebral Arteries by Moore, Christopher L, Nelson, Piper L, Parelkar, Nikhil K, Rusch, Nancy J, Rhee, Sung W

“…RATIONALE:Postsynaptic density-95 (PSD95) is a scaffolding protein that associates with voltage-gated, Shaker-type K (KV1) channels and promotes the expression…”
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A Novel, Unusually Efficacious Duocarmycin Carbamate Prodrug That Releases No Residual Byproduct by Wolfe, Amanda L, Duncan, Katharine K, Parelkar, Nikhil K, Weir, Scott J, Vielhauer, George A, Boger, Dale L

“…A unique heterocyclic carbamate prodrug of seco-CBI-indole2 that releases no residual byproduct is reported as a new member of a class of hydrolyzable prodrugs…”
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Efficacious Cyclic N‑Acyl O‑Amino Phenol Duocarmycin Prodrugs by Wolfe, Amanda L, Duncan, Katharine K, Parelkar, Nikhil K, Brown, Douglas, Vielhauer, George A, Boger, Dale L

“…Two novel cyclic N-acyl O-amino phenol prodrugs are reported as new members of a unique class of reductively cleaved prodrugs of the duocarmycin family of…”
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Phosphatidylinositol 3,5-bisphosphate increases intracellular free Ca2+ in arterial smooth muscle cells and elicits vasocontraction by Silswal, Neerupma, Parelkar, Nikhil K, Wacker, Michael J, Brotto, Marco, Andresen, Jon

“…Phosphoinositide (3,5)-bisphosphate [PI(3,5)P(2)] is a newly identified phosphoinositide that modulates intracellular Ca(2+) by activating ryanodine receptors…”
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Human cancer xenografts in outbred nude mice can be confounded by polymorphisms in a modifier of tumorigenesis by Zeineldin, Maged, Jensen, Derek, Paranjape, Smita R, Parelkar, Nikhil K, Jokar, Iman, Vielhauer, George A, Neufeld, Kristi L

“…Tumorigenicity studies often employ outbred nude mice, in the absence of direct evidence that this mixed genetic background will negatively affect experimental…”
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Evaluation of a reductively activated duocarmycin prodrug against murine and human solid cancers by Vielhauer, George A., Swink, Megan, Parelkar, Nikhil K., Lajiness, James P., Wolfe, Amanda L., Boger, Dale

“…In treating cancer with clinically approved chemotherapies, the high systemic toxicity and lack of selectivity for malignant cells often result in an overall…”
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Hyperbaric oxygen improves engraftment of ex-vivo expanded and gene transduced human CD34+ cells in a murine model of umbilical cord blood transplantation by Aljitawi, Omar S., Xiao, Yinghua, Eskew, Jeff D., Parelkar, Nikhil K., Swink, Megan, Radel, Jeff, Lin, Tara L., Kimler, Bruce F., Mahnken, Jonathan D., McGuirk, Joseph P., Broxmeyer, Hal E., Vielhauer, George

“…Delayed engraftment and graft failure represent major obstacles to successful umbilical cord blood (UCB) transplantation. Herein, we evaluated the use of…”
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Phosphatidylinositol 3,5-Bisphosphate (PI(3,5)P2) Potentiates Cardiac Contractility via Activation of the Ryanodine Receptor by Touchberry, Chad D., Bales, Ian K., Stone, Jessica K., Rohrberg, Travis J., Parelkar, Nikhil K., Nguyen, Tien, Fuentes, Oscar, Liu, Xia, Qu, Cheng-Kui, Andresen, Jon J., Valdivia, Héctor H., Brotto, Marco, Wacker, Michael J.

“…Phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2) is the most recently identified phosphoinositide, and its functions have yet to be fully elucidated…”
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2,2,2-trichloroethanol activates a nonclassical potassium channel in cerebrovascular smooth muscle and dilates the middle cerebral artery by Parelkar, Nikhil K, Silswal, Neerupma, Jansen, Kirsten, Vaughn, Joshua, Bryan, Jr, Robert M, Andresen, Jon

“…Trichloroacetaldehyde monohydrate [chloral hydrate (CH)] is a sedative/hypnotic that increases cerebral blood flow (CBF), and its active metabolite…”
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Amphetamine alters Ras-guanine nucleotide-releasing factor expression in the rat striatum in vivo by Parelkar, Nikhil K., Jiang, Qian, Chu, Xiang-Ping, Guo, Ming-Lei, Mao, Li-Min, Wang, John Q.

“…Ras-guanine nucleotide-releasing factors (Ras-GRFs) are densely expressed in neurons of the mammalian brain. As a Ras-specific activator predominantly…”
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Glutamate signaling to Ras-MAPK in striatal neurons: mechanisms for inducible gene expression and plasticity by Wang, John Q, Tang, Qingsong, Parelkar, Nikhil K, Liu, Zhenguo, Samdani, Shazia, Choe, Eun Sang, Yang, Lu, Mao, Limin

“…Extracellular signals can regulate mitogen-activated protein kinase (MAPK) cascades through a receptor-mediated mechanism in postmitotic neurons of adult…”
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Acute administration of cocaine reduces metabotropic glutamate receptor 8 protein expression in the rat striatum in vivo by Zhang, Guo-Chi, Vu, Khang, Parelkar, Nikhil K., Mao, Li-Min, Stanford, Ian M., Fibuch, Eugene E., Wang, John Q.

“…Metabotropic glutamate receptors (mGluRs) are densely expressed in the limbic system of the mammalian brain. Increasing evidence suggests a critical role of…”
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Cocaine increases Ras-guanine nucleotide-releasing factor 1 protein expression in the rat striatum in vivo by Zhang, Guo-Chi, Hoffmann, Jason, Parelkar, Nikhil K., Liu, Xian-Yu, Mao, Li-Min, Fibuch, Eugene E., Wang, John Q.

“…Psychostimulants activate the Ras-mitogen-activated protein kinase (Ras-MAPK) cascade in the limbic reward circuit and thereby trigger a…”
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