Search Results - "Parekh, Bhavin S"

Development and validation of an antibody-dependent cell-mediated cytotoxicity-reporter gene assay by Parekh, Bhavin S., Berger, Elaine, Sibley, Sharon, Cahya, Suntara, Xiao, Liqun, LaCerte, Melinda Ann, Vaillancourt, Peter, Wooden, Scott, Gately, Dennis

“…Humanized monoclonal antibodies (mAbs) are the fastest growing class of biological therapeutics that are being developed for various medical indications, and…”
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HDAC1 Acetylation Is Linked to Progressive Modulation of Steroid Receptor-Induced Gene Transcription by Qiu, Yi, Zhao, Yingming, Becker, Matthias, John, Sam, Parekh, Bhavin S., Huang, Suming, Hendarwanto, Anindya, Martinez, Elisabeth D., Chen, Yue, Lu, Hanxin, Adkins, Nicholas L., Stavreva, Diana A., Wiench, Malgorzata, Georgel, Philippe T., Schiltz, R. Louis, Hager, Gordon L.

“…Although histone deacetylases (HDACs) are generally viewed as corepressors, we show that HDAC1 serves as a coactivator for the glucocorticoid receptor (GR)…”
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Potency assignment of biotherapeutic reference standards by Faya, Paul, Borer, Matthew W., Griffiths, Kristi L., Parekh, Bhavin S.

“…•The biological potency of biotherapeutics is a critical quality attribute.•Potency must be determined by comparison to a reference standard.•The inability to…”
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Modulation of IgG1 immunoeffector function by glycoengineering of the GDP‐fucose biosynthesis pathway by Kelly, Ronan M., Kowle, Ronald L., Lian, Zhirui, Strifler, Beth A., Witcher, Derrick R., Parekh, Bhavin S., Wang, Tongtong, Frye, Christopher C.

“…Cross‐linking of the Fcγ receptors expressed on the surface of hematopoietic cells by IgG immune complexes triggers the activation of key immune effector…”
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Chromatin remodeling complexes interact dynamically with a glucocorticoid receptor-regulated promoter by Johnson, Thomas A, Elbi, Cem, Parekh, Bhavin S, Hager, Gordon L, John, Sam

“…Brahma (BRM) and Brahma-related gene 1 (BRG1) are the ATP-dependent catalytic subunits of the SWI/SNF family of chromatin-remodeling complexes. These complexes…”
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Virus Infection Leads to Localized Hyperacetylation of Histones H3 and H4 at the IFN-β Promoter by Parekh, Bhavin S, Maniatis, Tom

“…Transcriptional activation of the human interferon-β (IFN-β) gene by virus infection requires the assembly of a higher order nucleoprotein complex, the…”
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Virus Infection Induces the Assembly of Coordinately Activated Transcription Factors on the IFN-β Enhancer In Vivo by Wathelet, Marc G, Lin, Charles H, Parekh, Bhavin S, Ronco, Lucienne V, Howley, Peter M, Maniatis, Tom

“…We have identified a virus-activated factor (VAF) that binds to a regulatory element shared by different virus-inducible genes. We provide evidence that VAF…”
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Assembly of a Functional Beta Interferon Enhanceosome Is Dependent on ATF-2–c-jun Heterodimer Orientation by Falvo, James V., Parekh, Bhavin S., Lin, Charles H., Fraenkel, Ernest, Maniatis, Tom

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Stimulus-Specific Assembly of Enhancer Complexes on the Tumor Necrosis Factor Alpha Gene Promoter by Falvo, James V., Uglialoro, Adele M., Brinkman, Brigitta M. N., Merika, Menie, Parekh, Bhavin S., Tsai, Eunice Y., King, Hadley C., Morielli, Anthony D., Peralta, Ernest G., Maniatis, Tom, Thanos, Dimitris, Goldfeld, Anne E.

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Transcriptional Activation by Protein-Induced DNA Bending: Evidence for a DNA Structural Transmission Model by Parekh, Bhavin S., Hatfield, G. Wesley

“…Integration host factor (IHF) is a DNA-bending protein that binds to an upstream activating sequence (UAS1) and, on a negatively supercoiled DNA template,…”
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Inhibition of human papilloma virus E2 DNA binding protein by covalently linked polyamides by Schaal, Thomas D., Mallet, William G., McMinn, Dustin L., Nguyen, Nam V., Sopko, Michelle M., John, Sam, Parekh, Bhavin S.

“…Polyamides are a class of heterocyclic small molecules with the potential of controlling gene expression by binding to the minor groove of DNA in a…”
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Leucine-responsive Regulatory Protein-DNA Interactions in the Leader Region of the ilvGMEDA Operon of Escherichia coli by Rhee, K Y, Parekh, B S, Hatfield, G W

“…The leucine-responsive regulatory protein (Lrp) regulates the expression of many operons in Escherichia coli including several involved in the metabolism of…”
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Growth rate-related regulation of the ilvGMEDA operon of Escherichia coli K-12 is a consequence of the polar frameshift mutation in the ilvG gene of this strain by Parekh, B S, Hatfield, G W

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Effects of Integration Host Factor and DNA Supercoiling on Transcription from the ilvPG Promoter of Escherichia coli by Parekh, Bhavin S., Sheridan, Steven D., Hatfield, G. Wesley

“…Integration host factor (IHF) activates transcription from the ilvPG promoter by severely distorting the DNA helix in an upstream region of a supercoiled DNA…”
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Controlled lysis ofEscherichia Coli double-lysogen of bacteriophages λHL1 AND Φ434 by Koo, Yoon-Mo, Parekh, Bhavin S., Hatfield, G. Wesley, Lim, Henry C.

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