Search Results - "Pardoll, D"

Pathologic features of response to neoadjuvant anti-PD-1 in resected non-small-cell lung carcinoma: a proposal for quantitative immune-related pathologic response criteria (irPRC) by Cottrell, T.R., Thompson, E.D., Forde, P.M., Stein, J.E., Duffield, A.S., Anagnostou, V., Rekhtman, N., Anders, R.A., Cuda, J.D., Illei, P.B., Gabrielson, E., Askin, F.B., Niknafs, N., Smith, K.N., Velez, M.J., Sauter, J.L., Isbell, J.M., Jones, D.R., Battafarano, R.J., Yang, S.C., Danilova, L., Wolchok, J.D., Topalian, S.L., Velculescu, V.E., Pardoll, D.M., Brahmer, J.R., Hellmann, M.D., Chaft, J.E., Cimino-Mathews, A., Taube, J.M.

“…Neoadjuvant anti-PD-1 may improve outcomes for patients with resectable NSCLC and provides a critical window for examining pathologic features associated with…”
Get full text

The myeloid immune signature of enterotoxigenic Bacteroides fragilis-induced murine colon tumorigenesis by Thiele Orberg, E, Fan, H, Tam, A J, Dejea, C M, Destefano Shields, C E, Wu, S, Chung, L, Finard, B B, Wu, X, Fathi, P, Ganguly, S, Fu, J, Pardoll, D M, Sears, C L, Housseau, F

“…Enterotoxigenic Bacteroides fragilis (ETBF), a human commensal and candidate pathogen in colorectal cancer (CRC), is a potent initiator of interleukin-17…”
Get full text

T cells and tumours by Pardoll, D

“…The immune system's response to new tumors is complicated but seems to depend on where and when tumors develop. Pardoll discusses T-cell responses to tumors in…”
Get full text

Novel Allogeneic Granulocyte-Macrophage Colony-Stimulating Factor–Secreting Tumor Vaccine for Pancreatic Cancer: A Phase I Trial of Safety and Immune Activation by JAFFEE, Elizabeth M, HRUBAN, Ralph H, LILLEMOE, Keith D, O'REILLY, Seamus, ABRAMS, Ross A, PARDOLL, Drew M, CAMERON, John L, YEO, Charles J, BIEDRZYCKI, Barbara, LAHERU, Daniel, SCHEPERS, Karen, SAUTER, Patricia R, GOEMANN, Marti, COLEMAN, Joanne, GROCHOW, Louise, DONEHOWER, Ross C

“…Allogeneic granulocyte-macrophage colony-stimulating factor (GM-CSF)-secreting tumor vaccines can cure established tumors in the mouse, but their efficacy…”
Get full text

Inducing Autoimmune Disease to Treat Cancer by Pardoll, Drew M.

“…A new principle in cancer therapy states that the ability to induce tissue-specific autoimmunity will allow for the treatment of many important cancers…”
Get full text

Paracrine Cytokine Adjuvants in Cancer Immunotherapy by Pardoll, D M

“…Advances in our understanding of the molecular events of antigen recognition by T cells and T cell activation are opening up new approaches to cancer…”
Get full text

Spinning molecular immunology into successful immunotherapy by Pardoll, Drew M

“…Until recently, immunotherapies have been of limited success, particularly against cancer. However, recent insights into the cells, molecules and signalling…”
Get full text

Immunology. Stress, NK receptors, and immune surveillance by Pardoll, D M

Get full text

Enhancement of DNA vaccine potency by linkage of antigen gene to an HSP70 gene by CHEN, C.-H, WANG, T.-L, HUNG, C.-F, YANQIN YANG, YOUNG, R. A, PARDOLL, D. M, WU, T.-C

“…Nucleic acid vaccines represent an attractive approach to generating antigen-specific immunity because of their stability and simplicity of delivery. However,…”
Get full text

Treatment of established tumors with a novel vaccine that enhances major histocompatibility class II presentation of tumor antigen by KEN-YU LIN, GUARNIERI, F. G, STAVELEY-O'CARROLL, K. F, LEVITSKY, H. I, AUGUST, J. T, PARDOLL, D. M, TZYY-CHOOU WU

“…Presentation of antigenic peptides by MHC class II molecules to CD4+ T cells is critical to the generation of antitumor immunity. In an attempt to enhance MHC…”
Get full text

Expression of Programmed Death 1 Ligands by Murine T Cells and APC by Yamazaki, Tomohide, Akiba, Hisaya, Iwai, Hideyuki, Matsuda, Hironori, Aoki, Mami, Tanno, Yuka, Shin, Tahiro, Tsuchiya, Haruo, Pardoll, Drew M, Okumura, Ko, Azuma, Miyuki, Yagita, Hideo

“…Programmed death 1 (PD-1) is a new member of the CD28/CTLA-4 family, which has been implicated in the maintenance of peripheral tolerance. Two ligands for…”
Get full text

Role of LAG-3 in Regulatory T Cells by Huang, Ching-Tai, Workman, Creg J., Flies, Dallas, Pan, Xiaoyu, Marson, Aimee L., Zhou, Gang, Hipkiss, Edward L., Ravi, Sowmya, Kowalski, Jeanne, Levitsky, Hyam I., Powell, Jonathan D., Pardoll, Drew M., Drake, Charles G., Vignali, Dario A.A.

“…Regulatory T cells (Tregs) limit autoimmunity but also attenuate the magnitude of antipathogen and antitumor immunity. Understanding the mechanism of Treg…”
Get full text

Persistent Toll-like receptor signals are required for reversal of regulatory T cell-mediated CD8 tolerance by Yang, Yiping, Pardoll, Drew M, Huang, Ching-Tai, Huang, Xiaopei

“…One chief barrier to cancer immunotherapy is tumor-specific T cell tolerance. Here we compared the ability of hemagglutinin (HA)-encoding recombinant viruses…”
Get full text

Cancer vaccines by Pardoll, Drew M

“…Since the turn of the century, scientists have studied the interactions between the immune system and cancer cells so that antitumor immunity could be…”
Get full text

Bioactivity of autologous irradiated renal cell carcinoma vaccines generated by ex vivo granulocyte-macrophage colony-stimulating factor gene transfer by SIMONS, J. W, JAFFEE, E. M, HAUDA, K. M, BECK, L. A, LEIFERMAN, K. M, OWENS, A. H, PIANTADOSI, S, DRANOFF, G, MULLIGAN, R. C, PARDOLL, D. M, MARSHALL, F. F, WEBER, C. E, LEVITSKY, H. I, NELSON, W. G, CARDUCCI, M. A, LAZENBY, A. J, COHEN, L. K, FINN, C. C, CLIFT, S. M

“…Granulocyte-macrophage colony-stimulating factor (GM-CSF) gene-transduced, irradiated tumor vaccines induce potent, T-cell-mediated antitumor immune responses…”
Get full text

Vaccination with Irradiated Tumor Cells Engineered to Secrete Murine Granulocyte-Macrophage Colony-Stimulating Factor Stimulates Potent, Specific, and Long-Lasting Anti-Tumor Immunity by Dranoff, Glenn, Jaffee, Elizabeth, Lazenby, Audrey, Golumbek, Paul, Levitsky, Hyam, Brose, Katja, Jackson, Valerie, Hamada, Hirofumi, Pardoll, Drew, Mulligan, Richard C.

“…To compare the ability of different cytokines and other molecules to enhance the immunogenicity of tumor cells, we generated 10 retroviruses encoding potential…”
Get full text

Intramuscular administration of E7-transfected dendritic cells generates the most potent E7-specific anti-tumor immunity by WANG, T.-L, LING, M, SHIH, I.-M, PHAM, T, PAI, S, LU, Z, KURMAN, R, PARDOLL, D, WU, T.-C

“…Dendritic cells (DCs) are highly efficient antigen-presenting cells capable of priming both cytotoxic and helper T cells in vivo. Recent studies have…”
Get full text

Monocyte derived dendritic cells retain their functional capacity in patients following infection with hepatitis C virus by Barnes, E., Salio, M., Cerundolo, V., Francesco, L., Pardoll, D., Klenerman, P., Cox, A.

“…Studies assessing the function of monocyte derived dendritic cells (MD‐DC) in individuals with hepatitis C virus (HCV) infection have shown conflicting…”
Get full text

B7-DC, a new dendritic cell molecule with potent costimulatory properties for T cells by Tseng, S Y, Otsuji, M, Gorski, K, Huang, X, Slansky, J E, Pai, S I, Shalabi, A, Shin, T, Pardoll, D M, Tsuchiya, H

“…Dendritic cells (DCs), unique antigen-presenting cells (APCs) with potent T cell stimulatory capacity, direct the activation and differentiation of T cells by…”
Get full text

The role of CD4 + T cell responses in antitumor immunity by Pardoll, Drew M, Topalian, Suzanne L

“…While most of the focus in cancer immunology is on CD8 + cytotoxic T lymphocyte responses, recent evidence indicates that CD4 + T cells are an equally critical…”
Get full text