Search Results - "Pardo Andreu, Gilberto L."

Novel Iron Oxide Nanoparticles Induce Ferroptosis in a Panel of Cancer Cell Lines by Fernández-Acosta, Roberto, Iriarte-Mesa, Claudia, Alvarez-Alminaque, Daniel, Hassannia, Behrouz, Wiernicki, Bartosz, Díaz-García, Alicia M., Vandenabeele, Peter, Vanden Berghe, Tom, Pardo Andreu, Gilberto L.

“…The use of nanomaterials rationally engineered to treat cancer is a burgeoning field that has reported great medical achievements. Iron-based polymeric…”
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Mangifera indica L. extract (Vimang®) reduces plasma and liver cholesterol and leucocyte oxidative stress in hypercholesterolemic LDL receptor deficient mice by Dorighello, Gabriel G., Inada, Natália M., Paim, Bruno A., Pardo‐Andreu, Gilberto L., Vercesi, Anibal E., Oliveira, Helena C.F.

“…Cardiovascular diseases are major causes of death worldwide. Beyond the classical cholesterol risk factor, other conditions such as oxidative stress are well…”
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A Strong Protective Action of Guttiferone-A, a Naturally Occurring Prenylated Benzophenone, Against Iron-Induced Neuronal Cell Damage by Figueredo, Yanier Núñez, García-Pupo, Laura, Rubio, Osmany Cuesta, Hernández, René Delgado, Naal, Zeki, Curti, Carlos, Pardo Andreu, Gilberto L.

“…Guttiferone-A (GA) is a natural occurring polyisoprenylated benzophenone with several reported pharmacological actions. We have assessed the protective action…”
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Rapanone, a naturally occurring benzoquinone, inhibits mitochondrial respiration and induces HepG2 cell death by Pardo Andreu, Gilberto L., Reis, Felipe Zuccolotto Dos, González-Durruthy, Michael, Hernández, René Delgado, D'Vries, Richard F., Vanden Berghe, Wim, Alberici, Luciane C.

“…Rapanone is a natural occurring benzoquinone with several biological effects including unclear cytotoxic mechanisms. Here we addressed if mitochondria are…”
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Gossypitrin, A Naturally Occurring Flavonoid, Attenuates Iron-Induced Neuronal and Mitochondrial Damage by Bécquer-Viart, María Ángeles, Armentero-López, Adonis, Alvarez-Almiñaque, Daniel, Fernández-Acosta, Roberto, Matos-Peralta, Yasser, D’Vries, Richard F., Marín-Prida, Javier, Pardo-Andreu, Gilberto L.

“…The disruption of iron homeostasis is an important factor in the loss of mitochondrial function in neural cells, leading to neurodegeneration. Here, we…”
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Molecular Mechanisms of Nemorosone-Induced Ferroptosis in Cancer Cells by Fernández-Acosta, Roberto, Hassannia, Behrouz, Caroen, Jurgen, Wiernicki, Bartosz, Alvarez-Alminaque, Daniel, Verstraeten, Bruno, Van der Eycken, Johan, Vandenabeele, Peter, Vanden Berghe, Tom, Pardo-Andreu, Gilberto L

“…Ferroptosis is an iron-dependent cell death-driven by excessive peroxidation of polyunsaturated fatty acids (PUFAs) of membranes. A growing body of evidence…”
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The cytotoxic effects of VE-3N, a novel 1,4-dihydropyridine derivative, involve the mitochondrial bioenergetic disruption via uncoupling mechanisms by Marín-Prida, Javier, Pardo Andreu, Gilberto L., Rossignoli, Camila Pederiva, Durruthy, Michael González, Rodríguez, Estael Ochoa, Reyes, Yamila Verdecia, Acosta, Roberto Fernández, Uyemura, Sergio A., Alberici, Luciane C.

“…Several 1,4-dihydropyridine derivatives overcome the multidrug resistance in tumors, but their intrinsic cytotoxic mechanisms remain unclear. Here we addressed…”
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Fe(III) shifts the mitochondria permeability transition-eliciting capacity of mangiferin to protection of organelle by Pardo-Andreu, Gilberto L, Cavalheiro, Renata A, Dorta, Daniel J, Naal, Zeki, Delgado, René, Vercesi, Aníbal E, Curti, Carlos

“…Mangiferin acts as a strong antioxidant on mitochondria. However, when in the presence of Ca(2+), mangiferin elicits mitochondrial permeability transition…”
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The rationale for methylene blue utility against SARS-CoV-2 infection complications by Pardo Andreu, Gilberto L.

“…Context: Almost one year after the onset of COVID-19 pandemic in Wuhan, China and still no specific therapy has emerged, counting millions of dead worldwide…”
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JM-20, a novel hybrid molecule, protects against rotenone-induced neurotoxicity in experimental model of Parkinson’s disease by Fonseca-Fonseca, Luis Arturo, Wong-Guerra, Maylin, Ramírez-Sánchez, Jeney, Montano-Peguero, Yanay, Padrón Yaquis, Alejandro Saúl, Rodríguez, Abel Mondelo, da Silva, Víctor Diógenes Amaral, Costa, Silvia Lima, Pardo-Andreu, Gilberto L., Núñez-Figueredo, Yanier

“…•Novel hybrid molecule (JM-20) prevents rotenone-induced cell death.•JM-20 reduced oxidative stress and improved mitochondrial functions in rotenone-treated…”
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JM-20 Treatment After MCAO Reduced Astrocyte Reactivity and Neuronal Death on Peri-infarct Regions of the Rat Brain by Ramírez-Sánchez, Jeney, Pires, Elisa Nicoloso Simões, Meneghetti, André, Hansel, Gisele, Nuñez-Figueredo, Yanier, Pardo-Andreu, Gilberto L., Ochoa-Rodríguez, Estael, Verdecia-Reyes, Yamila, Delgado-Hernández, René, Salbego, Christianne, Souza, Diogo O

“…Stroke is frequently associated with severe neurological decline and mortality, and its incidence is expected to increase due to aging population. The only…”
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Novel arylidene malonate derivative, KM-34, showed neuroprotective effects on in vitro and in vivo models of ischemia/reperfusion by Ramírez-Sánchez, Jeney, Wong-Guerra, Maylin, Fonseca-Fonseca, Luis Arturo, Simões-Pires, Elisa Nicoloso, García-Pupo, Laura, Ochoa-Rodríguez, Estael, Verdecia-Reyes, Yamila, Delgado-Hernández, René, Salbego, Christianne, Souza, Diogo O., Pardo-Andreu, Gilberto L., Nuñez-Figueredo, Yanier

“…Cerebral ischemia constitutes the most frequent type of cerebrovascular disease. The reduction of blood supply to the brain initiates the ischemic cascade…”
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Mangifera indica extract (Vimang) impairs aversive memory without affecting open field behaviour or habituation in rats by Preissler, Thales, Martins, Márcio Rodrigo, Pardo-Andreu, Gilberto L, Henriques, João Antônio Pêgas, Quevedo, João, Delgado, Rene, Roesler, Rafael

“…Vimang is an aqueous extract of Mangifera indica L, used in Cuba for the treatment of immunopathological disorders. Increasing evidence from preclinical…”
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Discerning the antioxidant mechanism of rapanone: A naturally occurring benzoquinone with iron complexing and radical scavenging activities by de la Vega-Hernández, Karen, Antuch, Manuel, Cuesta-Rubio, Osmany, Núñez-Figueredo, Yanier, Pardo-Andreu, Gilberto L

“…Oxidative stress resulting from iron and reactive oxygen species (ROS) homeostasis breakdown has been implicated in several diseases. Therefore, molecules…”
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A novel multi-target ligand (JM-20) protects mitochondrial integrity, inhibits brain excitatory amino acid release and reduces cerebral ischemia injury in vitro and in vivo by Nuñez-Figueredo, Yanier, Ramírez-Sánchez, Jeney, Hansel, Gisele, Simões Pires, Elisa Nicoloso, Merino, Nelson, Valdes, Odalys, Delgado-Hernández, René, Parra, Alicia Lagarto, Ochoa-Rodríguez, Estael, Verdecia-Reyes, Yamila, Salbego, Christianne, Costa, Silvia L., Souza, Diogo O., Pardo-Andreu, Gilberto L.

“…We previously showed that JM-20, a novel 1,5-benzodiazepine fused to a dihydropyridine moiety, possessed an anxiolytic profile similar to diazepam and strong…”
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Mitochondrial involvement in memory impairment induced by scopolamine in rats by Wong-Guerra, Maylin, Jiménez-Martin, Javier, Pardo-Andreu, Gilberto L., Fonseca-Fonseca, Luis A., Souza, Diogo O., de Assis, Adriano M., Ramirez-Sanchez, Jeney, del Valle, Roberto Menéndez-Soto, Nuñez-Figueredo, Yanier

“…Objective: Scopolamine (SCO) administration to rats induces molecular features of AD and other dementias, including impaired cognition, increased oxidative…”
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New acridinone derivative with trypanocidal activity by Pardo Andreu, Gilberto L, Inada, Natalia M, Pellón, Rolando F, Docampo, Maite L, Fascio, Mirta L, D’Accorso, Norma B, Vercesi, Anibal E

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Antioxidant effects of JM-20 on rat brain mitochondria and synaptosomes: Mitoprotection against Ca2+ -induced mitochondrial impairment by Nuñez-Figueredo, Yanier, Pardo-Andreu, Gilberto L, Ramírez-Sánchez, Jeney, Delgado-Hernández, René, Ochoa-Rodríguez, Estael, Verdecia-Reyes, Yamila, Naal, Zeki, Muller, Alexandre Pastoris, Portela, Luis Valmor, Souza, Diogo O

“…Highlights • JM-20 is a strong antioxidant in brain mitochondria. • JM-20 did not directly react with H2 O2 or O2•− , but prevented their formation. • JM-20…”
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Multi-targeting effects of a new synthetic molecule (JM-20) in experimental models of cerebral ischemia by Nuñez-Figueredo, Yanier, Ramírez-Sánchez, Jeney, Pardo Andreu, Gilberto L, Ochoa-Rodríguez, Estael, Verdecia-Reyes, Yamila, Souza, Diogo O

“…Ischemic stroke is a major cause of death and disability worldwide. Thrombolysis by tissue plasminogen activator is the only pharmacological treatment approved…”
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Mangiferin, a naturally occurring glucoxilxanthone improves long-term object recognition memory in rats by Pardo Andreu, Gilberto L., Maurmann, Natasha, Reolon, Gustavo Kellermann, de Farias, Caroline B., Schwartsmann, Gilberto, Delgado, René, Roesler, Rafael

“…Mangiferin (2-β- d-glucopyranosyl-1,3,6,7-tetrahydroxyxanthone) is a xanthone widely distributed in higher plants showing antioxidative, antiviral, anticancer,…”
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