Search Results - "Pardieck, Iris N"

Dominant Antiviral CD8 + T Cell Responses Empower Prophylactic Antibody-Eliciting Vaccines Against Cytomegalovirus by Pardieck, Iris N, van Duikeren, Suzanne, Veerkamp, Dominique M B, Brasem, Dena J, Redeker, Anke, van Bergen, Jeroen, Han, Wanda, Ossendorp, Ferry, Zondag, Gerben, Arens, Ramon

“…Human cytomegalovirus (HCMV) is an ubiquitous herpesvirus that can cause serious morbidity and mortality in immunocompromised or immune-immature individuals. A…”
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Huwe1 supports B-cell development, B-cell-dependent immunity, somatic hypermutation and class switch recombination by regulating proliferation by Spanjaard, Aldo, Stratigopoulou, Maria, de Groot, Daniël, Aslam, Muhammad, van den Berk, Paul C M, Stappenbelt, Chantal, Ayidah, Matilda, Catsman, Joyce J I, Pardieck, Iris N, Kreft, Maaike, Arens, Ramon, Guikema, Jeroen E J, Jacobs, Heinz

“…The development and differentiation of B cells is intimately linked to cell proliferation and the generation of diverse immunoglobulin gene ( ) repertoires…”
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Delayed vaccine-induced CD8+ T cell expansion by topoisomerase I inhibition mediates enhanced CD70-dependent tumor eradication by van der Sluis, Tetje C, van Haften, Floortje J, van Duikeren, Suzanne, Pardieck, Iris N, de Graaf, J Fréderique, Vleeshouwers, Ward, van der Maaden, Koen, Melief, Cornelis J M, van der Burg, Sjoerd H, Arens, Ramon

“…BackgroundThe survival of patients with cervical cancer who are treated with cisplatin in conjunction with the topoisomerase I inhibitor topotecan is enhanced…”
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Multiantigen pan-sarbecovirus DNA vaccines generate protective T cell immune responses by van Bergen, Jeroen, Camps, Marcel Gm, Pardieck, Iris N, Veerkamp, Dominique, Leung, Wing Yan, Leijs, Anouk A, Myeni, Sebenzile K, Kikkert, Marjolein, Arens, Ramon, Zondag, Gerben C, Ossendorp, Ferry

“…SARS-CoV-2 is the third zoonotic coronavirus to cause a major outbreak in humans in recent years, and many more SARS-like coronaviruses with pandemic potential…”
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Cytomegalovirus infection and progressive differentiation of effector-memory T cells by Pardieck, Iris N, Beyrend, Guillaume, Redeker, Anke, Arens, Ramon

“…Primary cytomegalovirus (CMV) infection leads to strong innate and adaptive immune responses against the virus, which prevents serious disease. However, CMV…”
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Memory CD8+ T cell heterogeneity is primarily driven by pathogen-specific cues and additionally shaped by the tissue environment by van der Gracht, Esmé T.I., Beyrend, Guillaume, Abdelaal, Tamim, Pardieck, Iris N., Wesselink, Thomas H., van Haften, Floortje J., van Duikeren, Suzanne, Koning, Frits, Arens, Ramon

“…Factors that govern the complex formation of memory T cells are not completely understood. A better understanding of the development of memory T cell…”
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The hallmarks of CMV-specific CD8 T-cell differentiation by van den Berg, Sara P. H., Pardieck, Iris N., Lanfermeijer, Josien, Sauce, Delphine, Klenerman, Paul, van Baarle, Debbie, Arens, Ramon

“…Upon cytomegalovirus (CMV) infection, large T-cell responses are elicited that remain high or even increase over time, a phenomenon named memory T-cell…”
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Long-distance modulation of bystander tumor cells by CD8 + T cell-secreted IFNγ by Hoekstra, Mirjam E, Bornes, Laura, Dijkgraaf, Feline E, Philips, Daisy, Pardieck, Iris N, Toebes, Mireille, Thommen, Daniela S, van Rheenen, Jacco, Schumacher, Ton N M

“…T cell-secreted IFNγ can exert pleiotropic effects on tumor cells that include induction of immune checkpoints and antigen presentation machinery components,…”
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Histone methyltransferase DOT1L controls state-specific identity during B cell differentiation by Aslam, Muhammad Assad, Alemdehy, Mir Farshid, Kwesi-Maliepaard, Eliza Mari, Muhaimin, Fitriari Izzatunnisa, Caganova, Marieta, Pardieck, Iris N, van den Brand, Teun, van Welsem, Tibor, de Rink, Iris, Song, Ji-Ying, de Wit, Elzo, Arens, Ramon, Jacobs, Heinz, van Leeuwen, Fred

“…Differentiation of naïve peripheral B cells into terminally differentiated plasma cells is characterized by epigenetic alterations, yet the epigenetic…”
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A third vaccination with a single T cell epitope confers protection in a murine model of SARS-CoV-2 infection by Pardieck, Iris N., van der Sluis, Tetje C., van der Gracht, Esmé T. I., Veerkamp, Dominique M. B., Behr, Felix M., van Duikeren, Suzanne, Beyrend, Guillaume, Rip, Jasper, Nadafi, Reza, Beyranvand Nejad, Elham, Mülling, Nils, Brasem, Dena J., Camps, Marcel G. M., Myeni, Sebenzile K., Bredenbeek, Peter J., Kikkert, Marjolein, Kim, Yeonsu, Cicin-Sain, Luka, Abdelaal, Tamim, van Gisbergen, Klaas P. J. M., Franken, Kees L. M. C., Drijfhout, Jan Wouter, Melief, Cornelis J. M., Zondag, Gerben C. M., Ossendorp, Ferry, Arens, Ramon

“…Understanding the mechanisms and impact of booster vaccinations are essential in the design and delivery of vaccination programs. Here we show that a three…”
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Inhibiting the NADase CD38 improves cytomegalovirus-specific CD8+ T cell functionality and metabolism by Mülling, Nils, Behr, Felix M, Heieis, Graham A, Boss, Kristina, van Duikeren, Suzanne, van Haften, Floortje J, Pardieck, Iris N, van der Gracht, Esmé Ti, Vleeshouwers, Ward, van der Sluis, Tetje C, de Graaf, J Fréderique, Veerkamp, Dominique Mb, Franken, Kees Lmc, Lei, Xin, van de Sand, Lukas, van der Burg, Sjoerd H, Welters, Marij Jp, Heidt, Sebastiaan, Huisman, Wesley, Jochems, Simon P, Giera, Martin, Witzke, Oliver, de Vries, Aiko Pj, Kribben, Andreas, Everts, Bart, Wilde, Benjamin, Arens, Ramon

“…Cytomegalovirus (CMV) is one of the most common and relevant opportunistic pathogens in immunocompromised individuals such as kidney transplant recipients…”
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Publisher Correction: Long-distance modulation of bystander tumor cells by CD8 + T-cell-secreted IFN-γ by Hoekstra, Mirjam E, Bornes, Laura, Dijkgraaf, Feline E, Philips, Daisy, Pardieck, Iris N, Toebes, Mireille, Thommen, Daniela S, van Rheenen, Jacco, Schumacher, Ton N M

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Novel avenues in immunotherapies for colorectal cancer by Pardieck, Iris N, Jawahier, Priscilla A, Swets, Marloes, van de Velde, Cornelis J H, Kuppen, Peter J K

“…Since it is known that the immune system affects tumor growth, it has been studied if immunotherapy can be developed to combat cancer. While some successes…”
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Inhibiting the NADase CD38 improves cytomegalovirus-specific [CD8.sup.+] T cell functionality and metabolism by Mulling, Nils, Behr, Felix M, Heieis, Graham A, Boss, Kristina, van Duikeren, Suzanne, van Haften, Floortje J, Pardieck, Iris N, van der Gracht, Esme T.I, Vleeshouwers, Ward, van der Sluis, Tetje C, de Graaf, J. Frederique, Veerkamp, Dominique M.B, Franken, Kees L.M.C, Lei, Xin, van de Sand, Lukas, van der Burg, Sjoerd H, Welters, Marij J.P, Heidt, Sebastiaan, Huisman, Wesley, Jochems, Simon P, Giera, Martin, Witzke, Oliver, de Vries, Aiko P.J, Kribben, Andreas, Everts, Bart, Wilde, Benjamin, Arens, Ramon

“…Cytomegalovirus (CMV) is one of the most common and relevant opportunistic pathogens in people who are immunocompromised, such as kidney transplant recipients…”
Get full text

Inhibiting the NADase CD38 improves cytomegalovirus-specific CD8+ T cell functionality and metabolism by Mülling, Nils, Behr, Felix M, Heieis, Graham A, Boss, Kristina, Van duikeren, Suzanne, Van haften, Floortje J, Pardieck, Iris N, van der Gracht, Esmé T I, Vleeshouwers, Ward, van der Sluis, Tetje C, de Graaf, J Fréderique, Veerkamp, Dominique M B, Franken, Kees L M C, Lei, Xin, van de Sand, Lukas, van der burg, Sjoerd H, Welters, Marij J P, Heidt, Sebastiaan, Huisman, Wesley, Jochems, Simon P, Giera, Martin, Witzke, Oliver, de Vries, Aiko P J, Kribben, Andreas, Everts, Bart, Wilde, Benjamin, Arens, Ramon

“…Cytomegalovirus (CMV) is one of the most common and relevant opportunistic pathogens in people who are immunocompromised, such as kidney transplant recipients…”
Get full text

Multi-antigen pan-sarbecovirus DNA vaccines generate protective T cell immune responses by van Bergen, Jeroen, Camps, Marcel, Pardieck, Iris N, Veerkamp, Dominique, Leung, Wing Yan, Leijs, Anouk A, Myeni, Sebenzile K, Kikkert, Marjolein, Arens, Ramon, Zondag, Gerben C, Ossendorp, Ferry

“…SARS-CoV-2 is the third zoonotic coronavirus to cause a major outbreak in humans in recent years, and many more SARS-like coronaviruses with pandemic potential…”
Get full text